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  3. PF-06747711

PF-06747711 

Cat. No.: HY-112706 Purity: >99.0%
Handling Instructions

PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity.

For research use only. We do not sell to patients.

PF-06747711 Chemical Structure

PF-06747711 Chemical Structure

CAS No. : 1892576-58-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 176 In-stock
Estimated Time of Arrival: December 31
5 mg USD 160 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity[1].

IC50 & Target

IC50: 4.1 nM (RORC2)[1]

In Vitro

PF-06747711 (Compound 66) reduces IL-17 production by human Th17 cells with an IC50 of 9.5 nM[1].

In Vivo

PF-06747711 (10, 30, and 100 mg/kg, p.o., daily over 5 days) inhibits ear swelling in a dose-dependent manner in mice[1].

Animal Model: 8−10 week old female Balb/c mice[1]
Dosage: 10, 30, and 100 mg/kg
Administration: P.O. daily over 5 days
Result: Inhibited ear swelling, and caused a maximum inhibition of 46% at 100 mg/kg.
Molecular Weight

497.51

Formula

C₂₆H₂₆F₃N₅O₂

CAS No.

1892576-58-7

SMILES

O=C(NC1=CN=C(N(C)C=C2C3CCN(C(C(C)C)=O)CC3)C2=C1C(F)(F)F)C4=CC=CC(C#N)=C4

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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PF-06747711
Cat. No.:
HY-112706
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