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Cat. No.: HY-148237

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JNJ-54119936

JNJ-54119936, a chemical probe, is a RORγ (RORc) inverse agonist (K_d=5.3 nM).

For research use only. We do not sell to patients.

CAS No.: 1599531-55-1
Formula: C₃₄H₃₃ClN₄O₃
Molecular Weight:581.10

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

JNJ-54119936 Chemical Structure

CAS No.: 1599531-55-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

JNJ-54119936, a chemical probe, is a RORγ (RORc) inverse agonist (K_d=5.3 nM)^[1]^[2].

All ROR Isoforms :

Chemical Information

CAS No. 1599531-55-1
Molecular Weight 581.10
Formula C₃₄H₃₃ClN₄O₃
SMILES

O[C@@](C1CCN(CC1)C(C)=O)(C2=CC=CC=C2)C3=CC4=C(N=C(C(CC5=CC=C(N6C=CC=N6)C=C5)=C4Cl)OC)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Barbay JK, et al. 6-Substituted quinolines as RORγt inverse agonists. Bioorg Med Chem Lett. 2017 Dec 1;27(23):5277-5283. [Content Brief]

[2]. https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-54119936

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
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Chemical Information
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References

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JNJ-54119936

All ROR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JNJ-54119936 Related Classifications

HY-148237 Related Classifications