1. Metabolic Enzyme/Protease
  2. ROR
  3. ROR agonist-1

ROR agonist-1 

Cat. No.: HY-128353
Handling Instructions

ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5.

For research use only. We do not sell to patients.

ROR agonist-1 Chemical Structure

ROR agonist-1 Chemical Structure

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Description

ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5[1].

IC50 & Target

pIC 50: 7.5 (human primary TH 17 cells)[1]

Molecular Weight

526.45

Formula

C₂₁H₂₀F₆N₂O₅S

SMILES

O=C([[email protected]](NC(C)=O)C1=CC=C(S(=O)(CC)=O)C=C1)NC2=CC=C(C(O)(C(F)(F)F)C(F)(F)F)C=C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
ROR agonist-1
Cat. No.:
HY-128353
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