2361528-74-5
2361528-74-5
Chemical Structure
ROR agonist-1
- CAS No.: 2361528-74-5
- Formula:C21H20F6N2O5S
- Molecular Weight:526.45
IUPAC Name: (R)-2-acetamido-2-(4-(ethylsulfonyl)phenyl)-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)acetamide
InChIKey: HJJYGXDBXQAVQG-QGZVFWFLSA-N
SMILES: O=C([C@H](NC(C)=O)C1=CC=C(S(=O)(CC)=O)C=C1)NC2=CC=C(C(O)(C(F)(F)F)C(F)(F)F)C=C2
Biological Activity: ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5[1].
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ROR agonist-1 | ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5. | |||||||||||||||||||||
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Keywords
