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PSMC4 - proteasome 26S subunit, ATPase 4 Gene

Also Known as S6; RPT3; TBP7; TBP-7; MIP224

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5704

About PSMC4

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,971,165-39,981,764 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 198 orthologues and 5 paralogues. Ubiquitous expression in thyroid (RPKM 29.3), brain (RPKM 25.9) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S Proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

PSMC4 Products (2)

mRNA	Protein	Name
NM_006503.4	NP_006494.1	26S proteasome regulatory subunit 6B isoform 1
NM_153001.3	NP_694546.1	26S proteasome regulatory subunit 6B isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12525503	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of proteasome complex	IDA IDA: Inferred from direct assay	17323924	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMC4 Protein Structure

AAA

0
100
200
300
400
418 a.a.

Protein Preferred Names	Protein Names
26S proteasome regulatory subunit 6B	26S protease regulatory subunit 6B

PSMC4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PSMC4	P43686	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	PSMC4	P43686	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	PSMC4	P43686	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	PSMC4	P43686	PSMC1	Homo sapiens	P62191	Anti Tag CoIP	33961781
Intra	PSMC4	P43686	PSMC1	Homo sapiens	P62191	Anti Tag CoIP	35271311
Intra	PSMC4	P43686	PSMC1	Homo sapiens	P62191	Anti Bait CoIP	17353931
Intra	PSMC4	P43686	PSMC1	Homo sapiens	P62191	Solution Sedimentation	19490896
Intra	PSMC4	P43686	PSMC6	Homo sapiens	P62333	Anti Tag CoIP	33961781
Intra	PSMC4	P43686	PSMC6	Homo sapiens	P62333	Anti Tag CoIP	35271311
Intra	PSMC4	P43686	PSMC6	Homo sapiens	P62333	Solution Sedimentation	19490896
Intra	PSMC4	P43686	PSMC5	Homo sapiens	P62195	Y2H Prey Pooling	32296183
Intra	PSMC4	P43686	PSMC5	Homo sapiens	P62195	Anti Tag CoIP	35271311
Intra	PSMC4	P43686	PSMC5	Homo sapiens	P62195	Anti Bait CoIP	17353931
Intra	PSMC4	P43686	PSMC5	Homo sapiens	P62195	Y2H Pooling	16189514
Intra	PSMC4	P43686	PSMC5	Homo sapiens	P62195	Validated Y2H	32296183
Intra	PSMC4	P43686	PSMC5	Homo sapiens	P62195	Y2H Array	32296183
Intra	PSMC4	P43686	PSMC5	Homo sapiens	P62195	Anti Tag CoIP	19490896
Intra	PSMC4	P43686	PSMC5	Homo sapiens	P62195	Y2H Array	29892012
Intra	PSMC4	P43686	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	33961781
Intra	PSMC4	P43686	PSMD10	Homo sapiens	O75832	Validated Y2H	25416956
Intra	PSMC4	P43686	PSMD10	Homo sapiens	O75832	Anti Tag CoIP	24338975
Intra	PSMC4	P43686	PSMD10	Homo sapiens	O75832	Y2H Pooling	16189514
Intra	PSMC4	P43686	PSMD10	Homo sapiens	O75832	Anti Tag CoIP	12525503
Intra	PSMC4	P43686	PSMD10	Homo sapiens	O75832	Y2H Array	25416956
Intra	PSMC4	P43686	PSMD10	Homo sapiens	O75832	Anti Tag CoIP	33961781
Intra	PSMC4	P43686	PSMD10	Homo sapiens	O75832	Y2H Prey Pooling	32296183
Intra	PSMC4	P43686	PSMD10	Homo sapiens	O75832	Y2H Array	32296183
Intra	PSMC4	P43686	PSMD10	Homo sapiens	O75832	Y2H Prey Pooling	25416956
Intra	PSMC4	P43686	PSMD10	Homo sapiens	O75832	Y2H	12525503
Intra	PSMC4	P43686	PSMD10	Homo sapiens	O75832	Anti Tag CoIP	35271311
Intra	PSMC4	P43686	PSMD10	Homo sapiens	O75832	Anti Bait CoIP	17353931

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Episodic Ataxia, Type 2	Episodic Ataxia Type 2 EA2 Apca Capa Cerebellopathy, Hereditary Paroxysmal Acetazolamide-Responsive Hereditary Paroxysmal Cerebellar Ataxia Cerebellar Ataxia, Paroxysmal, Acetazolamide-Responsive Episodic Ataxia With Nystagmus Ataxia, Episodic, With Nystagmus Episodic Ataxia, Nystagmus-Associated Ataxia, Familial Paroxysmal Acetazolamide-Responsive Episodic Ataxia Syndrome Acetazolamide-Responsive, Hereditary, Paroxysmal, Cerebellar Ataxia Ataxia, Familial, Paroxysmal Nystagmus-Associated Episodic Ataxia Familial Paroxysmal Ataxia Episodic Ataxia 2 Ea-2 Episodic Ataxia Nystagmus-Associated Hereditary Paroxysmal Cerebellopathy Ataxia, Episodic, Type 2
Timothy Syndrome	Long Qt Syndrome With Syndactyly TS Lqt8 Long Qt Syndrome 8 Long Qt Syndrome Type 8 Long Qt Syndrome-Syndactyly Syndrome
Myotonia
Erythromelalgia	Primary Erythromelalgia Erythermalgia Primary Erythermalgia Mitchell Disease Familial Erythromelalgia
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-178997	NFE2L1 activator-1		98.93%	Unkown
HY-RS11314	PSMC4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21702	Psmc4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28220	Psmc4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PSMC4	VGNC	VGNC:33458
Canis familiaris	PSMC4	VGNC	VGNC:45104
Felis catus	PSMC4	VGNC	VGNC:69115
Rattus norvegicus	PSMC4	RGD	RGD:621102
Mus musculus	PSMC4	MGD	MGI:1346093
Macaca mulatta	PSMC4	VGNC	VGNC:76448
Others	PSMC4	NCBI