2. Apoptosis Metabolic Enzyme/Protease
  3. Ferroptosis Glutathione Peroxidase
  4. NFE2L1 activator-1

NFE2L1 activator-1 (Compound 5b) is a potent nuclear factor erythroid 2-related factor 1 (NFE2L1) activator (EC50 = 2.4 µM). NFE2L1 activator-1 effectively resists ferroptosis (Ferroptosis). NFE2L1 activator-1 can specifically activate the NFE2L1 signaling pathway to upregulate GPX4, PSMB7, PSMC4. NFE2L1 activator-1 can be used in cancer research.

For research use only. We do not sell to patients.

NFE2L1 activator-1

NFE2L1 activator-1 Chemical Structure

CAS No. : 3070514-51-8

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NFE2L1 activator-1 Related Antibodies

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Description

NFE2L1 activator-1 (Compound 5b) is a potent nuclear factor erythroid 2-related factor 1 (NFE2L1) activator (EC50 = 2.4 µM). NFE2L1 activator-1 effectively resists ferroptosis (Ferroptosis). NFE2L1 activator-1 can specifically activate the NFE2L1 signaling pathway to upregulate GPX4, PSMB7, PSMC4. NFE2L1 activator-1 can be used in cancer research[1].

In Vitro

NFE2L1 activator-1 potently activates NFE2L1-mediated transcription in HEK293 cells, with an EC50 of 2.4 μM[1].
NFE2L1 activator-1 (3 μM; 24 h) protects neuroblastoma SH-SY5Y cells against ferroptosis induced by erastin, RSL3 and FAC[1].
Treatment of SH-SY5Y neuroblastoma cells with NFE2L1 activator-1 (3 μM; 16 h) for 16 h upregulates the transcription of target genes of NFE2L1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NFE2L1 activator-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: HEK293 cells expressing HA-tagged NFE2L1
Concentration: 3 μM
Incubation Time: 16 h
Result: Stabilized the glycosylated (G) and deglycosylated full-length (FL) forms of both NFE2L1-HA and HA-NFE2L1.
Detected the proteolytically cleaved, transcriptionally active form (P) of NFE2L1-HA.

Real Time qPCR[1]

Cell Line: SH-SY5Y human neuroblastoma cells
Concentration: 3 μM
Incubation Time: 16 h
Result: Increased transcription levels of NFE2L1 target gene GPX4.
Increased transcription levels of NFE2L1 target gene PSMB7.
Increased transcription levels of NFE2L1 target gene PSMC4.
Molecular Weight

501.59

Formula

C26H31NO7S
CAS No.
SMILES

COC1=C(OC)C=CC(/C=C2CC(NS(=O)(CC)=O)C/C(C\2=O)=C\C3=CC=C(OC)C(OC)=C3)=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NFE2L1 activator-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NFE2L1 activator-13070514-51-8FerroptosisGlutathione Peroxidaseneurodegenerative diseasesHEK293 cellsSH-SY5Y human neuroblastoma cellsneuronal cellsGPX4PSMB7ferroptosisNFE2L1PSMC4Inhibitorinhibitorinhibit

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