THAP11 - THAP domain containing 11 Gene

Also Known as RONIN; CTG-B43a; CTG-B45d; HRIHFB2206

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57215

About THAP11

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,842,320-67,844,195 (from NCBI)

This gene has 1 transcript (splice variant) and 175 orthologues.

Summary

The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. [provided by RefSeq, Jul 2008]

THAP11 Products (1)

mRNA	Protein	Name
NM_020457.3	NP_065190.2	THAP domain-containing protein 11

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	23306615	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19008924	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19008924	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18330356	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	23306615	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19008924	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THAP11 Protein Structure

THAP

0
100
200
300
314 a.a.

Protein Preferred Names	Protein Names
THAP domain-containing protein 11

THAP11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	THAP11	Q96EK4	Casp3	Mus musculus	P70677	Protease Assay	18585351
Intra	THAP11	Q96EK4	VPS52	Homo sapiens	Q8N1B4	Y2H Array	25416956
Intra	THAP11	Q96EK4	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	25416956
Intra	THAP11	Q96EK4	PSMC5	Homo sapiens	P62195	Y2H	18330356
Intra	THAP11	Q96EK4	HCFC1	Homo sapiens	P51610	Y2H	18585351
Intra	THAP11	Q96EK4	HCFC1	Homo sapiens	P51610	Anti Tag CoIP	33961781
Intra	THAP11	Q96EK4	CTBP1	Homo sapiens	Q13363	Anti Tag CoIP	33961781
Intra	THAP11	Q96EK4	CTBP1	Homo sapiens	Q13363	Y2H Array	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

THAP11 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84729	THAP11 Antibody (YA4426)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84729A	THAP11 Antibody (YA4426)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Disorders Of Intracellular Cobalamin Metabolism
Methylmalonic Aciduria And Homocystinuria, Cblx Type	Mental Retardation, X-Linked 3 Methylmalonic Acidemia With Homocystinuria, Type Cblx MAHCX Intellectual Developmental Disorder, X-Linked 3 Xlid3 Mrx3 Methylmalonic Acidemia And Homocysteinemia Cblx Type Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cblx Methylmalonic Aciduria With Homocystinuria, Type Cblx Methylmalonic Acidemia And Homocysteinemia, Cblx Type Methylmalonic Aciduria And Homocysteinemia, Cblx Type Methylmalonic Aciduria And Homocysteinemia , Cblx Type Mental Retardation, X-Linked, Type 3
Methylmalonic Acidemia	Methylmalonic Aciduria Mma Acidemia, Methylmalonic Isolated Methylmalonic Acidemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14471	THAP11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20604	Thap11 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27112	Thap11 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	THAP11	VGNC	VGNC:66149
Bos taurus	THAP11	VGNC	VGNC:35819
Canis familiaris	THAP11	VGNC	VGNC:47325
Rattus norvegicus	THAP11	RGD	RGD:1310268
Mus musculus	THAP11	MGD	MGI:1930964
Macaca mulatta	THAP11	VGNC	VGNC:79381
Others	THAP11	NCBI