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THAP11 Antibody (YA4426)

(Synonyms: RONIN; CTG-B43a; CTG-B45d; HRIHFB2206; THAP11)
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THAP11 Antibody (YA4426) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to THAP11.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, IHC-P, ICC/IF, FC, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS with 0.05% sodium azide.

  • Conjugation:
    Non-conjugated
  • THAP11 Antibody (YA4426) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:500-2000 1:200-1000 1:200-1000 1:200-400 1:10000

Product Details

Description

THAP11 Antibody (YA4426) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to THAP11.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 44 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 34 kDa
Immunogen

Purified recombinant fragment of human THAP11 aa 137-313.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS with 0.05% sodium azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    THAP11 transcription factor, which has both transcriptional activation and repression activities. Also modulates chromatin accessibility. In complex with HCFC1 and ZNF143, regulates the expression of several genes, including AP2S1, ESCO2, OPHN1, RBL1, UBXN8 and ZNF32. May regulate the expression of genes that encode both cytoplasmic and mitochondrial ribosomal proteins. Required for normal mitochondrial development and function. Regulates mitochondrial gene expression, including that of components of the electron transport chain. Involved in the maintainance of pluripotency in early embryonic cells, possibly through its action on mitochondrial maturation which is required to meet high energy demands of these cells. Required for early development of retina, preventing premature exit of retinal progenitor cells from the cell cycle. This effect may also be mediated by its action on mitochondria. Through the regulation of MMACHC gene expression, controls cobalamin metabolism. Required for normal brain development and neural precursor differentiation. Involved in cell growth[1][2][3][4].

  • Subcellular Localization

    Nucleus; Cytoplasm

  • Expression


    Tissue_specificity:Expression in skin fibroblasts

  • Subunit

    Forms homodimers (PubMed:31905202). Interacts via HBM with HCFC1 (PubMed:31905202). Forms a complex with HCFC1 and ZNF143 (Probable)

  • SwissProt ID

    Q96EK4

  • Gene ID
    57215 [NCBI]
  • Synonyms

    RONIN; CTG-B43a; CTG-B45d; HRIHFB2206; THAP11

References

[1]. Dehaene H, et al. THAP11F80L cobalamin disorder-associated mutation reveals normal and pathogenic THAP11 functions in gene expression and cell proliferation. PLoS One. 2020;15(1):e0224646.

[2]. Ishii S, et al. Genome-wide ATAC-see screening identifies TFDP1 as a modulator of global chromatin accessibility. Nat Genet. 2024 Mar;56(3):473-482.

[3]. Vinckevicius A, et al. Genomic Determinants of THAP11/ZNF143/HCFC1 Complex Recruitment to Chromatin. Mol Cell Biol. 2015 Dec;35(24):4135-46. [Content Brief]

[4]. Quintana AM, et al. Mutations in THAP11 cause an inborn error of cobalamin metabolism and developmental abnormalities. Hum Mol Genet. 2017 Aug 1;26(15):2838-2849.

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THAP11 Antibody (YA4426) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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