CTBP1 - C-terminal binding protein 1 Gene
Also Known as BARS; HADDTS
Species: Homo sapiens
About CTBP1
This gene has 23 transcripts (splice variants), 228 orthologues, 3 paralogues and is associated with 4 phenotypes. Ubiquitous expression in spleen (RPKM 9.3), prostate (RPKM 7.1) and 25 other tissues.
Summary
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
CTBP1 Products (10)
| mRNA | Protein | Name |
|---|---|---|
| NM_001012614.2 | NP_001012632.1 | C-terminal-binding protein 1 isoform 2 |
| NM_001328.3 | NP_001319.1 | C-terminal-binding protein 1 isoform 1 |
| NM_001377186.1 | NP_001364115.1 | C-terminal-binding protein 1 isoform 3 |
| NM_001377187.1 | NP_001364116.1 | C-terminal-binding protein 1 isoform 4 |
| NM_001377188.1 | NP_001364117.1 | C-terminal-binding protein 1 isoform 4 |
| NM_001377189.1 | NP_001364118.1 | C-terminal-binding protein 1 isoform 4 |
| NM_001377190.1 | NP_001364119.1 | C-terminal-binding protein 1 isoform 4 |
| NM_001377191.1 | NP_001364120.1 | C-terminal-binding protein 1 isoform 2 |
| NM_001377192.1 | NP_001364121.1 | C-terminal-binding protein 1 isoform 2 |
| NM_001377193.1 | NP_001364122.1 | C-terminal-binding protein 1 isoform 2 |
CTBP1 Protein Structure
2-Hacid_dh: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (38 - 351)
2-Hacid_dh_C: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (134 - 317)
- 0
- 100
- 200
- 300
- 400
- 440 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
C-terminal-binding protein 1 |
|
CTBP1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CTBP1 | Q13363 | THAP11 | Homo sapiens | Q96EK4 | 21988832 | |
|
Intra
|
CTBP1 | Q13363 | THAP11 | Homo sapiens | Q96EK4 | 31041561 | |
|
Intra
|
CTBP1 | Q13363 | HIC1 | Homo sapiens | Q14526 | 16762039 | |
|
Intra
|
CTBP1 | Q13363 | ZNF516 | Homo sapiens | Q92618 | 33961781 | |
|
Intra
|
CTBP1 | Q13363 | ZNF516 | Homo sapiens | Q92618 | 28947780 | |
|
Intra
|
CTBP1 | Q13363 | ZNF516 | Homo sapiens | Q92618 | 28514442 | |
|
Intra
|
CTBP1 | Q13363 | ZNF516 | Homo sapiens | Q92618 | 35016035 | |
|
Intra
|
CTBP1 | Q13363 | ZNF516 | Homo sapiens | Q92618 | 35271311 | |
|
Intra
|
CTBP1 | Q13363 | ZNF516 | Homo sapiens | Q92618 | 31041561 | |
|
Intra
|
CTBP1 | Q13363 | ZNF366 | Homo sapiens | Q8N895 | 17085477 | |
|
Intra
|
CTBP1 | Q13363 | ZNF366 | Homo sapiens | Q8N895 | 17085477 | |
|
Intra
|
CTBP1 | Q13363 | ZNF366 | Homo sapiens | Q8N895 | 17085477 | |
|
Intra
|
CTBP1 | Q13363 | ZBTB18 | Homo sapiens | Q99592 | 33961781 | |
|
Intra
|
CTBP1 | Q13363 | ZBTB18 | Homo sapiens | Q99592 | 24722188 | |
|
Intra
|
CTBP1 | Q13363 | HEMGN | Homo sapiens | Q9BXL5 | 21988832 | |
|
Intra
|
CTBP1 | Q13363 | LCORL | Homo sapiens | Q8N3X6 | 33961781 | |
|
Intra
|
CTBP1 | Q13363 | LCORL | Homo sapiens | Q8N3X6 | 28514442 | |
|
Intra
|
CTBP1 | Q13363 | LCORL | Homo sapiens | Q8N3X6 | 31041561 | |
|
Intra
|
CTBP1 | Q13363 | LCORL | Homo sapiens | Q8N3X6 | 21900206 | |
|
Intra
|
CTBP1 | Q13363 | LCORL | Homo sapiens | Q8N3X6 | 35016035 | |
|
Intra
|
CTBP1 | Q13363 | CBX4 | Homo sapiens | O00257 | 33961781 | |
|
Intra
|
CTBP1 | Q13363 | CBX4 | Homo sapiens | O00257 | 28514442 | |
|
Intra
|
CTBP1 | Q13363 | KLF4 | Homo sapiens | O43474 | 19751731 | |
|
Intra
|
CTBP1 | Q13363 | KLF4 | Homo sapiens | O43474 | 19751731 | |
|
Intra
|
CTBP1 | Q13363 | CTBP2 | Homo sapiens | P56545 | 35016035 | |
|
Intra
|
CTBP1 | Q13363 | CTBP2 | Homo sapiens | P56545 | 33961781 | |
|
Intra
|
CTBP1 | Q13363 | CTBP2 | Homo sapiens | P56545 | 28947780 | |
|
Intra
|
CTBP1 | Q13363 | CTBP2 | Homo sapiens | P56545 | 31041561 | |
|
Intra
|
CTBP1 | Q13363 | CTBP2 | Homo sapiens | P56545 | 26496610 | |
|
Intra
|
CTBP1 | Q13363 | CTBP2 | Homo sapiens | P56545 | 35271311 | |
|
Intra
|
CTBP1 | Q13363 | CTBP2 | Homo sapiens | P56545 | 35016035 | |
|
Intra
|
CTBP1 | Q13363 | LCOR | Homo sapiens | Q96JN0 | 20211142 | |
|
Intra
|
CTBP1 | Q13363 | LCOR | Homo sapiens | Q96JN0 | 33961781 | |
|
Intra
|
CTBP1 | Q13363 | LCOR | Homo sapiens | Q96JN0 | 28514442 | |
|
Intra
|
CTBP1 | Q13363 | LCOR | Homo sapiens | Q96JN0 | 35016035 | |
|
Intra
|
CTBP1 | Q13363 | LCOR | Homo sapiens | Q96JN0 | 31041561 | |
|
Intra
|
CTBP1 | Q13363 | LCOR | Homo sapiens | Q96JN0 | 35271311 | |
|
Intra
|
CTBP1 | Q13363 | RAI2 | Homo sapiens | Q9Y5P3 | 24722188 | |
|
Intra
|
CTBP1 | Q13363 | RAI2 | Homo sapiens | Q9Y5P3 | 35016035 | |
|
Intra
|
CTBP1 | Q13363 | RAI2 | Homo sapiens | Q9Y5P3 | 35016035 | |
|
Intra
|
CTBP1 | Q13363 | NRIP1 | Homo sapiens | P48552 | 35016035 | |
|
Intra
|
CTBP1 | Q13363 | NRIP1 | Homo sapiens | P48552 | 24722188 | |
|
Intra
|
CTBP1 | Q13363 | TERF2IP | Homo sapiens | Q9NYB0 | 21044950 | |
|
Intra
|
CTBP1 | Q13363 | TERF2IP | Homo sapiens | Q9NYB0 | 21044950 |
CTBP1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82285 | CTBP1 Antibody (YA2030) | WB, IHC-P, ICC/IF, IP | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Hypotonia, Ataxia, Developmental Delay, And Tooth Enamel Defect Syndrome |
|
|
| Chromosome 4p Deletion |
|
|
| Wolf-Hirschhorn Syndrome |
|
|
| Colorectal Cancer |
|
|
| Hypotonia |
|
|
| Holoprosencephaly |
|
|
| Hepatocellular Carcinoma |
|
|
| Mowat-Wilson Syndrome |
|
|
| Fanconi Anemia, Complementation Group A |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | CTBP1 | RGD | RGD:2441 |
| Bos taurus | CTBP1 | VGNC | VGNC:27785 |
| Canis familiaris | CTBP1 | VGNC | VGNC:39686 |
| Macaca mulatta | CTBP1 | VGNC | VGNC:71539 |
| Mus musculus | CTBP1 | MGD | MGI:1201685 |
| Felis catus | CTBP1 | VGNC | VGNC:61242 |
| Others | CTBP1 | NCBI |