CTBP1 - C-terminal binding protein 1 Gene

Also Known as BARS; HADDTS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1487

About CTBP1

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:1,211,445-1,250,355 (from NCBI)

This gene has 23 transcripts (splice variants), 228 orthologues, 3 paralogues and is associated with 4 phenotypes. Ubiquitous expression in spleen (RPKM 9.3), prostate (RPKM 7.1) and 25 other tissues.

Summary

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

CTBP1 Products (10)

mRNA Protein Name
NM_001012614.2 NP_001012632.1 C-terminal-binding protein 1 isoform 2
NM_001328.3 NP_001319.1 C-terminal-binding protein 1 isoform 1
NM_001377186.1 NP_001364115.1 C-terminal-binding protein 1 isoform 3
NM_001377187.1 NP_001364116.1 C-terminal-binding protein 1 isoform 4
NM_001377188.1 NP_001364117.1 C-terminal-binding protein 1 isoform 4
NM_001377189.1 NP_001364118.1 C-terminal-binding protein 1 isoform 4
NM_001377190.1 NP_001364119.1 C-terminal-binding protein 1 isoform 4
NM_001377191.1 NP_001364120.1 C-terminal-binding protein 1 isoform 2
NM_001377192.1 NP_001364121.1 C-terminal-binding protein 1 isoform 2
NM_001377193.1 NP_001364122.1 C-terminal-binding protein 1 isoform 2

CTBP1 Protein Structure

2-Hacid_dh

2-Hacid_dh: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (38 - 351)

2-Hacid_dh_C

2-Hacid_dh_C: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (134 - 317)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 440 a.a.
Protein Preferred Names Protein Names

C-terminal-binding protein 1

  • brefeldin A-ribosylated substrate

CTBP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CTBP1 Q13363 THAP11 Homo sapiens Q96EK4 21988832
Intra
CTBP1 Q13363 THAP11 Homo sapiens Q96EK4 31041561
Intra
CTBP1 Q13363 HIC1 Homo sapiens Q14526 16762039
Intra
CTBP1 Q13363 ZNF516 Homo sapiens Q92618 33961781
Intra
CTBP1 Q13363 ZNF516 Homo sapiens Q92618
GMS
28947780
Intra
CTBP1 Q13363 ZNF516 Homo sapiens Q92618 28514442
Intra
CTBP1 Q13363 ZNF516 Homo sapiens Q92618 35016035
Intra
CTBP1 Q13363 ZNF516 Homo sapiens Q92618 35271311
Intra
CTBP1 Q13363 ZNF516 Homo sapiens Q92618 31041561
Intra
CTBP1 Q13363 ZNF366 Homo sapiens Q8N895 17085477
Intra
CTBP1 Q13363 ZNF366 Homo sapiens Q8N895 17085477
Intra
CTBP1 Q13363 ZNF366 Homo sapiens Q8N895
Y2H
17085477
Intra
CTBP1 Q13363 ZBTB18 Homo sapiens Q99592 33961781
Intra
CTBP1 Q13363 ZBTB18 Homo sapiens Q99592 24722188
Intra
CTBP1 Q13363 HEMGN Homo sapiens Q9BXL5 21988832
Intra
CTBP1 Q13363 LCORL Homo sapiens Q8N3X6 33961781
Intra
CTBP1 Q13363 LCORL Homo sapiens Q8N3X6 28514442
Intra
CTBP1 Q13363 LCORL Homo sapiens Q8N3X6 31041561
Intra
CTBP1 Q13363 LCORL Homo sapiens Q8N3X6
Y2H
21900206
Intra
CTBP1 Q13363 LCORL Homo sapiens Q8N3X6 35016035
Intra
CTBP1 Q13363 CBX4 Homo sapiens O00257 33961781
Intra
CTBP1 Q13363 CBX4 Homo sapiens O00257 28514442
Intra
CTBP1 Q13363 KLF4 Homo sapiens O43474 19751731
Intra
CTBP1 Q13363 KLF4 Homo sapiens O43474 19751731
Intra
CTBP1 Q13363 CTBP2 Homo sapiens P56545 35016035
Intra
CTBP1 Q13363 CTBP2 Homo sapiens P56545 33961781
Intra
CTBP1 Q13363 CTBP2 Homo sapiens P56545
GMS
28947780
Intra
CTBP1 Q13363 CTBP2 Homo sapiens P56545 31041561
Intra
CTBP1 Q13363 CTBP2 Homo sapiens P56545 26496610
Intra
CTBP1 Q13363 CTBP2 Homo sapiens P56545 35271311
Intra
CTBP1 Q13363 CTBP2 Homo sapiens P56545 35016035
Intra
CTBP1 Q13363 LCOR Homo sapiens Q96JN0 20211142
Intra
CTBP1 Q13363 LCOR Homo sapiens Q96JN0 33961781
Intra
CTBP1 Q13363 LCOR Homo sapiens Q96JN0 28514442
Intra
CTBP1 Q13363 LCOR Homo sapiens Q96JN0 35016035
Intra
CTBP1 Q13363 LCOR Homo sapiens Q96JN0 31041561
Intra
CTBP1 Q13363 LCOR Homo sapiens Q96JN0 35271311
Intra
CTBP1 Q13363 RAI2 Homo sapiens Q9Y5P3 24722188
Intra
CTBP1 Q13363 RAI2 Homo sapiens Q9Y5P3 35016035
Intra
CTBP1 Q13363 RAI2 Homo sapiens Q9Y5P3 35016035
Intra
CTBP1 Q13363 NRIP1 Homo sapiens P48552 35016035
Intra
CTBP1 Q13363 NRIP1 Homo sapiens P48552 24722188
Intra
CTBP1 Q13363 TERF2IP Homo sapiens Q9NYB0 21044950
Intra
CTBP1 Q13363 TERF2IP Homo sapiens Q9NYB0 21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

CTBP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82285 CTBP1 Antibody (YA2030) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Hypotonia, Ataxia, Developmental Delay, And Tooth Enamel Defect Syndrome
  • HADDTS

Chromosome 4p Deletion
  • 4p Partial Monosomy Syndrome

  • Chromosome 4 Short Arm Deletion

  • 4p Deletion

  • 4p Monosomy

  • Deletion 4p

  • Monosomy 4p

  • Partial Monosomy 4p

  • Wolf-Hirschhorn Syndrome

  • Chromosome 4 Short Arm Deletion Syndrome

  • Deletion Of Short Arm Of Chromosome 4

Wolf-Hirschhorn Syndrome
  • Pitt-Rogers-Danks Syndrome

  • WHS

  • Chromosome 4p16.3 Deletion Syndrome

  • Wittwer Syndrome

  • 4p- Syndrome

  • Pitt Syndrome

  • 4p Deletion Syndrome

  • Distal Deletion 4p

  • Distal Monosomy 4p

  • Telomeric Deletion 4p

  • Prds

  • 4p Syndrome

  • Chromosome 4p Syndrome

  • Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation

  • Wolf Syndrome

  • Chromosome 4p Deletion Syndrome

  • Chromosome 4p Monosomy

  • Del Syndrome

  • Monosomy 4p

  • Partial Monosomy 4p

  • Chromosome 4 Short Arm Deletion

Colorectal Cancer
  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon

Hypotonia
Holoprosencephaly
  • Holoprosencephaly Sequence

  • Hpe

  • Hpe - [Holoprosencephaly]

Hepatocellular Carcinoma
  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour

Mowat-Wilson Syndrome
  • MOWS

  • Microcephaly, Mental Retardation, And Distinct Facial Features, With Or Without Hirschsprung Disease

  • Hirschsprung Disease-Mental Retardation Syndrome

  • Mowat-Wilson Syndrome Due To Monosomy 2q22

  • Hirschsprung Disease Mental Retardation Syndrome

  • Microcephaly, Mental Retardation, And Distinct Facial Featrues, With Or Without Hirschprung Disease

  • Hirschsprung Disease - Intellectual Disability Syndrome

  • Hirschsprung Disease Intellectual Disability Syndrome

  • Intellectual Disability, Microcephaly, And Distinct Facial Features With Or Without Hirschsprung Disease

  • Mws

  • Hirschsprung Disease-Intellectual Disability Syndrome

  • Hirschsprung Disease And Intellectual Disability Due To 2q22 Microdeletion

  • Hirschsprung Disease And Intellectual Disability Due To Del(2)(Q22)

  • Hirschsprung Disease And Intellectual Disability Due To Monosomy 2q22

  • Mowat-Wilson Syndrome Due To 2q22 Microdeletion

  • Mowat-Wilson Syndrome Due To Del(2)Q(22)

  • Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation

  • Hirschsprung Disease And Intellectual Disability Due To A Zeb2 Point Mutation

Fanconi Anemia, Complementation Group A
  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CTBP1 RGD RGD:2441
Bos taurus CTBP1 VGNC VGNC:27785
Canis familiaris CTBP1 VGNC VGNC:39686
Macaca mulatta CTBP1 VGNC VGNC:71539
Mus musculus CTBP1 MGD MGI:1201685
Felis catus CTBP1 VGNC VGNC:61242
Others CTBP1 NCBI