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HIC1 - HIC ZBTB transcriptional repressor 1 Gene

Also Known as hic-1; ZBTB29; ZNF901

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3090

About HIC1

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:2,055,103-2,063,241 (from NCBI)

This gene has 7 transcripts (splice variants), 189 orthologues, 36 paralogues and is associated with 1 phenotype. Broad expression in fat (RPKM 8.9), endometrium (RPKM 4.9) and 19 other tissues.

Summary

This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010]

HIC1 Products (2)

mRNA	Protein	Name
NM_001098202.1	NP_001091672.1	hypermethylated in cancer 1 protein isoform 2
NM_006497.4	NP_006488.2	hypermethylated in cancer 1 protein isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15231840	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15231840	GOA
enables histone deacetylase binding	IDA IDA: Inferred from direct assay	12052894	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12052894	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15231840	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in intrinsic apoptotic signaling pathway in response to DNA damage	IDA IDA: Inferred from direct assay	16269335	GOA
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	16724116	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12052894	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HIC1 Protein Structure

BTB

zf-C2H2_4

zf-C2H2

zf-H2C2_2

0
200
400
600
733 a.a.

Protein Preferred Names	Protein Names
hypermethylated in cancer 1 protein	hypermethylated in cancer 1

HIC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	HIC1	Q14526	Ctbp2	Mus musculus	P56546	Y2H	16762039
Cross	HIC1	Q14526	Ctbp1	Mus musculus	O88712	Y2H	12052894
Cross	HIC1	Q14526	Ctbp1	Mus musculus	O88712	Pull Down	12052894
Cross	HIC1	Q14526	Ctbp1	Mus musculus	O88712	Anti Bait CoIP	16762039
Cross	HIC1	Q14526	Ctbp1	Mus musculus	O88712	Y2H	16762039
Intra	HIC1	Q14526	ARID1A	Homo sapiens	O14497	Y2H	19486893
Intra	HIC1	Q14526	CTBP2	Homo sapiens	P56545	Y2H	19486893
Intra	HIC1	Q14526	CTBP1	Homo sapiens	Q13363	Y2H	19486893
Intra	HIC1	Q14526	TCF7L2	Homo sapiens	Q9NQB0	Imaging	16724116
Intra	HIC1	Q14526	TCF7L2	Homo sapiens	Q9NQB0	Pull Down	16724116
Intra	HIC1	Q14526	TCF7L2	Homo sapiens	Q9NQB0	Anti Bait CoIP	16724116
Intra	HIC1	Q14526	TCF7L2	Homo sapiens	Q9NQB0	Anti Tag CoIP	16724116

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Miller-Dieker Lissencephaly Syndrome	Miller-Dieker Syndrome Mds MDLS Miller Dieker Syndrome Classical Lissencephaly Syndrome Lissencephaly Due To 17p13.3 Deletion Monosomy 17p13.3 Telomeric Deletion 17p Classical Lissencephaly
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Bilateral Breast Cancer	Bilateral Breast Carcinoma
Adult Central Nervous System Primitive Neuroectodermal Neoplasm	Adult Cns Pnet Adult Central Nervous System Primitive Neuroectodermal Tumor
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W540188A	Calcium mesoxalate trihydrate		98.5%	Unkown
HY-RS06165	HIC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HIC1	VGNC	VGNC:99076
Canis familiaris	HIC1	VGNC	VGNC:41683
Mus musculus	HIC1	MGD	MGI:1338010
Rattus norvegicus	HIC1	RGD	RGD:1307527
Bos taurus	HIC1	VGNC	VGNC:29845
Others	HIC1	NCBI