TCF7L2 - transcription factor 7 like 2 Gene

Also Known as TCF4; TCF-4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6934

About TCF7L2

Cytogenetic location: 10q25.2-q25.3 Genomic coordinates (GRCh38): 10:112,950,247-113,167,678 (from NCBI)

This gene has 31 transcripts (splice variants), 201 orthologues, 3 paralogues and is associated with 89 phenotypes. Ubiquitous expression in fat (RPKM 12.8), colon (RPKM 11.3) and 25 other tissues.

Summary

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

TCF7L2 Products (34)

mRNA	Protein	Name
NM_001146274.2	NP_001139746.1	transcription factor 7-like 2 isoform 1
NM_001146283.2	NP_001139755.1	transcription factor 7-like 2 isoform 3
NM_001146284.2	NP_001139756.1	transcription factor 7-like 2 isoform 4
NM_001146285.2	NP_001139757.1	transcription factor 7-like 2 isoform 5
NM_001146286.2	NP_001139758.1	transcription factor 7-like 2 isoform 6
NM_001198525.2	NP_001185454.1	transcription factor 7-like 2 isoform 7
NM_001198526.2	NP_001185455.1	transcription factor 7-like 2 isoform 8
NM_001198527.2	NP_001185456.1	transcription factor 7-like 2 isoform 9
NM_001198528.2	NP_001185457.1	transcription factor 7-like 2 isoform 10
NM_001198529.2	NP_001185458.1	transcription factor 7-like 2 isoform 11
NM_001198530.2	NP_001185459.1	transcription factor 7-like 2 isoform 12
NM_001198531.2	NP_001185460.1	transcription factor 7-like 2 isoform 13
NM_001349870.2	NP_001336799.1	transcription factor 7-like 2 isoform 14
NM_001349871.1	NP_001336800.1	transcription factor 7-like 2 isoform 15
NM_001363501.2	NP_001350430.1	transcription factor 7-like 2 isoform 16
NM_001367943.1	NP_001354872.1	transcription factor 7-like 2 isoform 17
NM_030756.5	NP_110383.2	transcription factor 7-like 2 isoform 2
NM_001146274.2	NP_001139746.1	transcription factor 7-like 2 isoform 1
NM_001146283.2	NP_001139755.1	transcription factor 7-like 2 isoform 3
NM_001146284.2	NP_001139756.1	transcription factor 7-like 2 isoform 4
NM_001146285.2	NP_001139757.1	transcription factor 7-like 2 isoform 5
NM_001146286.2	NP_001139758.1	transcription factor 7-like 2 isoform 6
NM_001198525.2	NP_001185454.1	transcription factor 7-like 2 isoform 7
NM_001198526.2	NP_001185455.1	transcription factor 7-like 2 isoform 8
NM_001198527.2	NP_001185456.1	transcription factor 7-like 2 isoform 9
NM_001198528.2	NP_001185457.1	transcription factor 7-like 2 isoform 10
NM_001198529.2	NP_001185458.1	transcription factor 7-like 2 isoform 11
NM_001198530.2	NP_001185459.1	transcription factor 7-like 2 isoform 12
NM_001198531.2	NP_001185460.1	transcription factor 7-like 2 isoform 13
NM_001349870.2	NP_001336799.1	transcription factor 7-like 2 isoform 14
NM_001349871.1	NP_001336800.1	transcription factor 7-like 2 isoform 15
NM_001363501.2	NP_001350430.1	transcription factor 7-like 2 isoform 16
NM_001367943.1	NP_001354872.1	transcription factor 7-like 2 isoform 17
NM_030756.5	NP_110383.2	transcription factor 7-like 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	9727977	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19443654	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16007074	GOA
enables armadillo repeat domain binding	IPI IPI: Inferred from physical interaction	12408825	GOA
enables beta-catenin binding	EXP EXP: Inferred from Experiment	11713476	GOA
enables beta-catenin binding	IDA IDA: Inferred from direct assay	9065401	GOA
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	11237626	GOA
enables gamma-catenin binding	IPI IPI: Inferred from physical interaction	14661054	GOA
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	12799378	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11713475	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16714285	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14661054	GOA
enables sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	16532032	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	20128911	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in blood vessel development	IMP IMP: Inferred from mutant phenotype	15578569	GOA
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	17072303	GOA
involved in fat cell differentiation	IDA IDA: Inferred from direct assay	10937998	GOA
involved in glucose homeostasis	IDA IDA: Inferred from direct assay	15525634	GOA
involved in maintenance of DNA repeat elements	IMP IMP: Inferred from mutant phenotype	18755497	GOA
involved in myoblast fate commitment	IDA IDA: Inferred from direct assay	10937998	GOA
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12799378	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12799378	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16532032	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	16532032	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12799378	GOA
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	12408868	GOA
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	17072303	GOA
involved in positive regulation of heparan sulfate proteoglycan biosynthetic process	IMP IMP: Inferred from mutant phenotype	15853773	GOA
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	19386626	GOA
acts upstream of positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	19386626	GOA
involved in positive regulation of protein binding	IDA IDA: Inferred from direct assay	12799378	GOA
involved in positive regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	19386626	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9065401	GOA
involved in regulation of hormone metabolic process	IDA IDA: Inferred from direct assay	15525634	GOA
involved in regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17122440	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9727977	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of beta-catenin-TCF7L2 complex	IDA IDA: Inferred from direct assay	9065401	GOA
located in chromatin	IDA IDA: Inferred from direct assay	19443654	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	19168596	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9065401	GOA
part of protein-DNA complex	IDA IDA: Inferred from direct assay	14661054	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCF7L2 Protein Structure

CTNNB1_binding

HMG_box

0
100
200
300
400
500
602 a.a.

Protein Preferred Names	Protein Names
transcription factor 7-like 2	HMG box transcription factor 4

TCF7L2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TCF7L2	Q9NQB0	TNIK	Homo sapiens	Q9UKE5	Anti Bait CoIP	19816403
Intra	TCF7L2	Q9NQB0	HIC1	Homo sapiens	Q14526	Pull Down	16724116
Intra	TCF7L2	Q9NQB0	XRCC6	Homo sapiens	P12956	Anti Tag CoIP	17283121
Intra	TCF7L2	Q9NQB0	XRCC6	Homo sapiens	P12956	Pull Down	30833792
Intra	TCF7L2	Q9NQB0	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	17283121
Intra	TCF7L2	Q9NQB0	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	16569639
Intra	TCF7L2	Q9NQB0	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	18772112
Intra	TCF7L2	Q9NQB0	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	22056988
Intra	TCF7L2	Q9NQB0	CTNNB1	Homo sapiens	P35222	X-Ray Diffraction	11713475
Intra	TCF7L2	Q9NQB0	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	17283121
Intra	TCF7L2	Q9NQB0	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	16569639
Intra	TCF7L2	Q9NQB0	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	18772112
Intra	TCF7L2	Q9NQB0	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	19816403
Intra	TCF7L2	Q9NQB0	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	22014570
Intra	TCF7L2	Q9NQB0	CTNNB1	Homo sapiens	P35222	X-Ray Diffraction	11713476
Intra	TCF7L2	Q9NQB0	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	17283121
Intra	TCF7L2	Q9NQB0	DAXX	Homo sapiens	Q9UER7	Y2H	16569639
Intra	TCF7L2	Q9NQB0	DAXX	Homo sapiens	Q9UER7	Anti Tag CoIP	16569639
Intra	TCF7L2	Q9NQB0	RUNX3	Homo sapiens	Q13761	CH-IP	18772112
Intra	TCF7L2	Q9NQB0	RUNX3	Homo sapiens	Q13761	Anti Tag CoIP	18772112
Intra	TCF7L2	Q9NQB0	RUNX3	Homo sapiens	Q13761	Anti Bait CoIP	18772112

Cross: Cross-species interaction Intra: Intraspecies interaction

TCF7L2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80520	TCF-4/TCF7L2 Antibody (YA039)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
HY-P82422	TCF-4/TCF7L2 Antibody (YA2167)	WB, IHC-P, ICC/IF, FC	Human
HY-P82422A	TCF-4/TCF7L2 Antibody (YA2167)(PBS only)	WB, IHC-P, IP	Human

Related Diseases

Diseases	Alias
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Gestational Diabetes	Gestational Diabetes Mellitus GDM Diabetes Mellitus Arising In Pregnancy Maternal Gestational Diabetes Mellitus Diabetes Mellitus, Gestational Diabetes Mellitus, Pregnancy Related Diabetes, Pregnancy-Induced Diabetes Gestational Diabetes, Gestational Diabetes Of Pregnancy Gdm - [Gestational Diabetes Mellitus] Gestational Diabetes Mellitus Nos Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium
Diabetes Mellitus	Diabetes
Glucose Intolerance	Glucose: Intolerance Glucose: Malabsorption Malabsorption Of Glucose Impaired Glucose Tolerance
Wolfram Syndrome 1	WFS1 Didmoad Wfs Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome Wolfram Syndrome
Familial Adenomatous Polyposis	Adenomatous Polyposis Coli Fap Familial Polyposis Coli Familial Multiple Polyposis Syndrome Adenomatous Polyposis Of The Colon Familial Intestinal Polyposis Fpc Familial Adenomatous Polyposis Of The Colon Familial Multiple Polyposis Familial Polyposis Of The Colon Hereditary Polyposis Coli Polyposis, Adenomatous Intestinal Adenomatous Familial Polyposis Adenomatous Familial Polyposis Syndrome Myh-Associated Polyposis Colorectal Adenomatous Polyposis Adenomatous Polyposis, Familial Mutyh-Associate Polyposis
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Arrhythmogenic Right Ventricular Cardiomyopathy	Arrhythmogenic Right Ventricular Dysplasia Arvc Arvd Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Arvc Cardiomyopathy Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia Arvd/C Right Ventricular Dysplasia, Arrhythmogenic Ventricular Dysplasia, Right, Arrhythmogenic Cardiomyopathy, Ventricular, Right, Arrhythmogenic Dysplasia, Arrhythmogenic Right Ventricular
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Prediabetes Syndrome	Prediabetes Impaired Glucose Tolerance Prediabetic State IGT Igt - [Impaired Glucose Tolerance] Impaired Glucose Tolerance With Unspecified Complication Impaired Glucose Tolerance Without Complication Abnormal Glucose Tolerance
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset
Wolfram Syndrome	Didmoad Syndrome Didmoad Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Wfs Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness Didmoadud Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Maturity-Onset Diabetes Of The Young, Type 3	Maturity-Onset Diabetes Of The Young Type 3 MODY3 Mody, Type Iii Mody Type 3 Mody, Type 3 Maturity-Onset Diabetes Of The Young 3 Mody-3 Diabetes Of The Young, Maturity-Onset, Type 3
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W010995	2,5-Dimethylcelecoxib	Inhibitor	99.57%	Unkown
HY-N3628	Coronarin A	Inhibitor	≥98.0%	Unkown
HY-RS14310	TCF7L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17858	Tcf7l2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24327	Tcf7l2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TCF7L2	VGNC	VGNC:55976
Mus musculus	TCF7L2	MGD	MGI:1202879
Felis catus	TCF7L2	VGNC	VGNC:66029
Macaca mulatta	TCF7L2	VGNC	VGNC:78290
Canis familiaris	TCF7L2	VGNC	VGNC:47200
Rattus norvegicus	TCF7L2	RGD	RGD:1583621
Others	TCF7L2	NCBI