2. Gene
  3. TNIK - TRAF2 and NCK interacting kinase Gene

TNIK - TRAF2 and NCK interacting kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MRT54

Gene ID: 23043 | Gene type: protein coding

About TNIK

Cytogenetic location: 3q26.2-q26.31 Genomic coordinates (GRCh38): 3:171,058,414-171,460,408 (from NCBI)

This gene has 15 transcripts (splice variants), 268 orthologues, 35 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 10.5), small intestine (RPKM 7.1) and 20 other tissues.

Summary

Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]

TNIK Products(9)

mRNA Protein Name
NM_001161564.3 NP_001155036.1 TRAF2 and NCK-interacting protein kinase isoform 6
NM_001161565.3 NP_001155037.1 TRAF2 and NCK-interacting protein kinase isoform 7
NM_001161560.3 NP_001155032.1 TRAF2 and NCK-interacting protein kinase isoform 2
NM_001161566.3 NP_001155038.1 TRAF2 and NCK-interacting protein kinase isoform 8
NM_001161561.3 NP_001155033.1 TRAF2 and NCK-interacting protein kinase isoform 3
NM_001161563.3 NP_001155035.1 TRAF2 and NCK-interacting protein kinase isoform 5
NM_015028.4 NP_055843.1 TRAF2 and NCK-interacting protein kinase isoform 1
NR_027767.2
NM_001161562.3 NP_001155034.1 TRAF2 and NCK-interacting protein kinase isoform 4

TNIK Protein Structure

Pkinase

Pkinase: Protein kinase domain (25 - 289)

CNH

CNH: CNH domain (1052 - 1330)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1360 a.a.
Protein Preferred Names Protein Names

TRAF2 and NCK-interacting protein kinase

Related Diseases

Diseases Alias
Scoliosis
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid
Intellectual Developmental Disorder, Autosomal Recessive 54

MRT54

Mental Retardation, Autosomal Recessive 54
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (21)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100830 NCB-0846 Inhibitor 99.61% Unkown
HY-111754 DMX-5804 Inhibitor 99.83% Unkown
HY-10371 Pim1/AKK1-IN-1 Inhibitor 98.20% Unkown
HY-124745 KY-05009 99.24% Unkown
HY-145293 TNIK-IN-3 Inhibitor 99.88% Unkown
HY-124762 TNIK-IN-1 98.08% Unkown
HY-143437 TNIK-IN-5 Inhibitor 99.75% Unkown
HY-N3127 Orobol Inhibitor 99.28% Unkown
HY-156502 TINK-IN-1 Inhibitor 98.02% Unkown
HY-156816 ON 108600 Inhibitor 99.73% Unkown
HY-156817 TNIK-IN-6 / Unkown
HY-156818 TNIK-IN-7 99.90% Unkown
HY-143436 TNIK-IN-4 Inhibitor / Unkown
HY-145292 TNIK-IN-2 / Unkown
HY-156523 TNIK&MAP4K4-IN-1 / Unkown
HY-162314 TNIK-IN-8 Inhibitor / Unkown
HY-163478 TNIK-IN-9 Inhibitor / Unkown
HY-RS14831 TNIK Human Pre-designed siRNA Set A / Unkown
HY-RS14832 Tnik Mouse Pre-designed siRNA Set A / Unkown
HY-RS14833 Tnik Rat Pre-designed siRNA Set A / Unkown
HY-160623 TNIK&MAP4K4-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TNIK VGNC VGNC:36179
Macaca mulatta TNIK VGNC VGNC:81595
Felis catus TNIK VGNC VGNC:97666
Mus musculus TNIK MGD MGI:1916264
Rattus norvegicus TNIK RGD RGD:1561817
Canis familiaris TNIK VGNC VGNC:47675
Others TNIK NCBI