TNIK - TRAF2 and NCK interacting kinase Gene

Also Known as MRT54

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23043

About TNIK

Cytogenetic location: 3q26.2-q26.31 Genomic coordinates (GRCh38): 3:171,058,414-171,460,408 (from NCBI)

This gene has 15 transcripts (splice variants), 268 orthologues, 35 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 10.5), small intestine (RPKM 7.1) and 20 other tissues.

Summary

Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]

TNIK Products (9)

mRNA Protein Name
NM_001161564.3 NP_001155036.1 TRAF2 and NCK-interacting protein kinase isoform 6
NM_001161565.3 NP_001155037.1 TRAF2 and NCK-interacting protein kinase isoform 7
NM_001161560.3 NP_001155032.1 TRAF2 and NCK-interacting protein kinase isoform 2
NM_001161566.3 NP_001155038.1 TRAF2 and NCK-interacting protein kinase isoform 8
NM_001161561.3 NP_001155033.1 TRAF2 and NCK-interacting protein kinase isoform 3
NM_001161563.3 NP_001155035.1 TRAF2 and NCK-interacting protein kinase isoform 5
NM_015028.4 NP_055843.1 TRAF2 and NCK-interacting protein kinase isoform 1
NR_027767.2
NM_001161562.3 NP_001155034.1 TRAF2 and NCK-interacting protein kinase isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10521462 GOA
enables protein kinase activity IDA
IDA: Inferred from direct assay
22797597 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10521462 GOA
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IDA
IDA: Inferred from direct assay
15342639 GOA
involved in cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
10521462 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
10521462 GOA
involved in microvillus assembly IMP
IMP: Inferred from mutant phenotype
22797597 GOA
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
15342639 GOA
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
10521462 GOA
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
22797597 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
10521462 GOA
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
22797597 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
10521462 GOA
involved in regulation of dendrite morphogenesis IDA
IDA: Inferred from direct assay
20159449 GOA
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
22797597 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
15342639 GOA
located in cytoskeleton IDA
IDA: Inferred from direct assay
15342639 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19816403 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNIK Protein Structure

Pkinase

Pkinase: Protein kinase domain (25 - 289)

CNH

CNH: CNH domain (1052 - 1330)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1360 a.a.
Protein Preferred Names Protein Names

TRAF2 and NCK-interacting protein kinase

TNIK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNIK Q9UKE5 TRAF2 Homo sapiens Q12933
Anti Bait CoIP
22904686
Intra
TNIK Q9UKE5 TRAF2 Homo sapiens Q12933
Pull Down
22904686
Intra
TNIK Q9UKE5 MAP3K7 Homo sapiens O43318
Anti Tag CoIP
22904686
Intra
TNIK Q9UKE5 MAP3K7 Homo sapiens O43318
Anti Bait CoIP
22904686
Intra
TNIK Q9UKE5 TAB2 Homo sapiens Q9NYJ8
Anti Tag CoIP
22904686
Intra
TNIK Q9UKE5 TAB2 Homo sapiens Q9NYJ8
Anti Bait CoIP
22904686
Intra
TNIK Q9UKE5 TRAF6 Homo sapiens Q9Y4K3
Pull Down
22904686
Intra
TNIK Q9UKE5 TRAF6 Homo sapiens Q9Y4K3
Anti Bait CoIP
22904686
Intra
TNIK Q9UKE5 TRAF6 Homo sapiens Q9Y4K3
Anti Tag CoIP
22904686
Intra
TNIK Q9UKE5 NCK1 Homo sapiens P16333
Peptide Array
17474147
Intra
TNIK Q9UKE5 CTNNB1 Homo sapiens P35222
Pull Down
19816403
Intra
TNIK Q9UKE5 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
19816403
Intra
TNIK Q9UKE5 DISC1 Homo sapiens Q9NRI5
Pull Down
32707033
Intra
TNIK Q9UKE5 DISC1 Homo sapiens Q9NRI5
Anti Tag CoIP
29961565
Intra
TNIK Q9UKE5 IKBKB Homo sapiens O14920
Anti Bait CoIP
22904686
Intra
TNIK Q9UKE5 IKBKB Homo sapiens O14920
Anti Tag CoIP
22904686
Intra
TNIK Q9UKE5 TCF7L2 Homo sapiens Q9NQB0
Anti Bait CoIP
19816403
Intra
TNIK Q9UKE5 TCF7L2 Homo sapiens Q9NQB0
Pull Down
19816403
Cross
TNIK Q9UKE5 LMP1 Epstein-Barr virus P03230
Anti Tag CoIP
22904686
Cross
TNIK Q9UKE5 LMP1 Epstein-Barr virus P03230
Anti Bait CoIP
22904686
Cross: Cross-species interaction Intra: Intraspecies interaction

TNIK Antibodies

Cat. No. Product Name Application Reactivity
HY-P89577 TNIK Antibody (YA8921) WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA human, mouse, rat

Related Diseases

Diseases Alias
Scoliosis
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Autosomal Recessive Non-Syndromic Intellectual Disability

  • Ar-Nsid

  • Ns-Arid
Intellectual Developmental Disorder, Autosomal Recessive 54

  • MRT54

  • Mental Retardation, Autosomal Recessive 54
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (30)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160623 Rentosertib 99.96% Unkown
HY-100830 NCB-0846 Inhibitor 99.61% Unkown
HY-10371 Pim1/AAK1-IN-1 Inhibitor 98.40% Unkown
HY-111754 DMX-5804 Inhibitor 99.83% Unkown
HY-124745 KY-05009 99.88% Unkown
HY-N3127 Orobol Inhibitor 99.74% Unkown
HY-145293 TNIK-IN-3 Inhibitor 99.79% Unkown
HY-156816 ON 108600 Inhibitor 98.65% Unkown
HY-149591 M4K-2009 Inhibitor 99.35% Unkown
HY-124762 TNIK-IN-1 Inhibitor 99.25% Unkown
HY-156502 TINK-IN-1 Inhibitor 98.02% Unkown
HY-162314 TNIK-IN-8 Inhibitor 99.58% Unkown
HY-122805 PF-794 Inhibitor 99.19% Unkown
HY-156818 TNIK-IN-7 Inhibitor 99.65% Unkown
HY-100830A NCB-0970 Control 98.81% Unkown
HY-156817 TNIK-IN-6 Inhibitor 98.28% Unkown
HY-143437 TNIK-IN-5 Inhibitor 99.75% Unkown
HY-156523 TNIK&MAP4K4-IN-1 99.73% Unkown
HY-RS14832 Tnik Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14831 TNIK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-143436 TNIK-IN-4 Inhibitor / Unkown
HY-145292 TNIK-IN-2 Inhibitor 99.68% Unkown
HY-163478 TNIK-IN-9 Inhibitor / Unkown
HY-179111 HPK1-IN-64 Inhibitor / Unkown
HY-181930 TNIK-IN-10 / Unkown
HY-183059 TNIK-IN-11 Inhibitor / Unkown
HY-183950 ALK5-IN-87 Inhibitor / Unkown
HY-RS14833 Tnik Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W402208 MAP4K4-IN-7 Inhibitor / Unkown
HY-180857 TNIK modulator-1 / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TNIK VGNC VGNC:36179
Macaca mulatta TNIK VGNC VGNC:81595
Felis catus TNIK VGNC VGNC:97666
Mus musculus TNIK MGD MGI:1916264
Rattus norvegicus TNIK RGD RGD:1561817
Canis familiaris TNIK VGNC VGNC:47675
Others TNIK NCBI