TNIK-IN-11

TNIK-IN-11 (Compound E) (0.1-1 μM) potently inhibits purified recombinant human TNIK protein with a pIC₅₀ of 7.80, achieving 86.1% inhibition at 0.1 μM and 99.9% inhibition at 1 μM^[1].
TNIK-IN-11 (0.3-10 μM; 2 days) promotes neurite outgrowth in human Dup15-1 iPSC-derived cortical neurons in a concentration-dependent manner, reaching a maximum of 149.1% of control neurite length at 3 μM over 2 days^[1].
TNIK-IN-11 (3 μM; 14 days) significantly enhances neurite outgrowth from human HC-4 iPSC-derived neural organoids, increasing total neurite length to ~220% of DMSO control^[1].
TNIK-IN-11 (3 μM; 3 days) modulates gene expression in human HC-4 iPSC-derived neural organoids to activate neurite outgrowth-associated pathways^[1].
TNIK-IN-11 (3 μM; 3 days) increases AKT phosphorylation in human HC-4 iPSC-derived cortical neurons, supporting neurotrophic signaling activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.