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Cat. No.: HY-143436

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TNIK-IN-4

TNIK-IN-4 is a potent TNIK inhibitor with IC₅₀ of 0.61 μM. TNIK-IN-4 has inhibitory activity against typical colorectal cancer cell line HCT116.

For research use only. We do not sell to patients.

CAS No.: 2754266-04-9
Formula: C₂₀H₁₆FN₃O₃
Molecular Weight:365.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

TNIK-IN-4 Chemical Structure

CAS No.: 2754266-04-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

TNIK-IN-4 is a potent TNIK inhibitor with IC₅₀ of 0.61 μM. TNIK-IN-4 has inhibitory activity against typical colorectal cancer cell line HCT116^[1].

IC₅₀ & Target

IC₅₀: 0.61 μM (TNIK)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	36.423 μM Compound: 5a	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 35447345]

In Vitro

TNIK-IN-4 (compound 5a) (0.4-100 μM; 72 hours) has inhibitory activity against typical colorectal cancer cell line HCT116 with IC₅₀ of 36.423 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:

HCT116 cells^[1]
Concentration:

0.4, 1.2, 3.7, 11.1, 33.3 and 100 μM
Incubation Time:

72 hours
Result:

Showed inhibitory activity against typical colorectal cancer cell line HCT116 with IC₅₀ of 36.423 μM.

Chemical Information

CAS No. 2754266-04-9
Molecular Weight 365.36
Formula C₂₀H₁₆FN₃O₃
SMILES

O=C1OC2=CC(C3=CC(OC)=C(N)N=C3)=CC=C2N1CC4=CC=C(F)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Luo X, Yang R, Li Y, Zhang L, Yang S, Li L. Discovery of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer. Bioorg Med Chem Lett. 2022;67:128745. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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