1. MAPK/ERK Pathway
  2. MAP4K

DMX-5804 

Cat. No.: HY-111754
Handling Instructions

DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice.

For research use only. We do not sell to patients.

DMX-5804 Chemical Structure

DMX-5804 Chemical Structure

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice[1].

IC50 & Target[1]

MAP4K4

3 nM (IC50)

MAP4K4

8.55 (pIC50)

MINK1/MAP4K6

8.18 (pIC50)

TNIK/MAP4K7

7.96 (pIC50)

GCK/MAP4K2

6.50 (pIC50)

KHS/MAP4K5

6.36 (pIC50)

GLK/MAP4K3

4.95 (pIC50)

MLK1/MAP3K9

7.19 (pIC50)

MLK3/MAP3K11

6.99 (pIC50)

NUAK

6.88 (pIC50)

VEGFR

5.72 (pIC50)

ABL1

5.80 (pIC50)

Aurora B

5.49 (pIC50)

FLT3

5.31 (pIC50)

GSK3β

4.66 (pIC50)

In Vitro

DMX-5804 exhibits great selectivity at MAP4K4 over other kinases, such as GCK/MAP4K2 (pIC50, 6.50), GLK/MAP4K3 (pIC50, 4.95), KHS/MAP4K5 (pIC50, 6.36), ABL1 (pIC50, 5.80), Aurora B (pIC50, 5.49), FLT3 (pIC50, 5.31), GSK3β (pIC50, 4.66), MLK1/MAP3K9 (pIC50, 7.19), MLK3/MAP3K11 (pIC50, 6.99), NUAK (pIC50, 6.88) and VEGFR (pIC50, 5.72)[1].

References
Molecular Weight

361.39

Formula

C₂₁H₁₉N₃O₃

SMILES

O=C1NC=NC2=C1C(C3=CC=C(OCCOC)C=C3)=CN2C4=CC=CC=C4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
DMX-5804
Cat. No.:
HY-111754
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DMX-5804

Cat. No.: HY-111754