2. NF-κB
  3. NF-κB
  4. TNIK-IN-9

TNIK-IN-9 (Compound 54) is a selective and potent NIK inhibitor, with an IC50 of 1.27 nM. TNIK-IN-9 can inhibit pro-inflammatory cytokines and nitric oxide production. TNIK-IN-9 exhibits significant anti-inflammatory effects, improved mortality, and hepatoprotective effects in sepsis models.

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TNIK-IN-9

TNIK-IN-9 Chemical Structure

CAS No. : 3038178-73-0

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TNIK-IN-9 Related Antibodies

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Description

TNIK-IN-9 (Compound 54) is a selective and potent NIK inhibitor, with an IC50 of 1.27 nM. TNIK-IN-9 can inhibit pro-inflammatory cytokines and nitric oxide production. TNIK-IN-9 exhibits significant anti-inflammatory effects, improved mortality, and hepatoprotective effects in sepsis models[1].

In Vitro

TNIK-IN-9 (5 μM, 2 h) decreases the levels of inflammatory cytokines and chemokines (TNF-α, IL-6, IL-1β, and CCL12, respectively) in LPS and CD40 induced RAW264.7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TNIK-IN-9 Related Antibodies
In Vivo

TNIK-IN-9 (10 mg/kg, i.p., once time) inhibits the secretion of inflammatory cytokines (TNF-α, IL-1β, CXCL-12, IL-6, IFN-γ) in LPS induced mice[1].

Pharmacokinetic Analysis in C57BL/6J Mouse Model[1]

Route Dose (mg/kg) AUClast (ng·h/mL) AUCinf (ng·h/mL) T1/2 (h) C0 (ng/mL) CL (mL/min/kg) Cmax (ng/mL) Tmax(h)
i.v. 10 3019 3021 0.741 5059 56.2 / /
i.p. 10 2525 2551 2.27 / / 1280 0.50

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS induced mice[1]
Dosage: 10 mg/kg
Administration: i.p., once time
Result: Decreased the levels of AST, ALT, and AKP.
Reduced necrosis and inflammatory cell infiltration.
Decreased the p52 protein levels and increased p100 protein levels.
Molecular Weight

487.53

Formula

C24H21N7O3S
CAS No.
SMILES

O[C@@](C1=NC=CS1)(C#CC2=NN3C(N(CCC3)C4=CC=NC(NC5=CC6=C(C=C5)OCO6)=N4)=C2)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TNIK-IN-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNIK-IN-93038178-73-0NF-κBNuclear factor-κBNuclear factor-kappaBsepsis modelspro-inflammatory cytokinesnitric oxideanti-inflammatoryhepatoprotectivemortalityInhibitorinhibitorinhibit

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