Ctbp1 - C-terminal binding protein 1 Gene

Also Known as BARS; D4S115h; D5H4S115; D5H4S115E; CtBP3/BARS

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13016

Summary

Enables chromatin binding activity. Involved in negative regulation of transcription, DNA-templated and white fat cell differentiation. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription repressor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Is expressed in several structures, including central nervous system; genitourinary system; limb; lung; and neural retina. Orthologous to human CTBP1 (C-terminal binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ctbp1 Products (5)

mRNA	Protein	Name
NM_001198859.1	NP_001185788.1	C-terminal-binding protein 1 isoform 1
NM_001198860.1	NP_001185789.1	C-terminal-binding protein 1 isoform 2
NM_001198861.1	NP_001185790.1	C-terminal-binding protein 1 isoform 4
NM_001310535.1	NP_001297464.1	C-terminal-binding protein 1 isoform 5
NM_013502.3	NP_038530.1	C-terminal-binding protein 1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	14701752	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	17392792	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11390982	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18483224	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17392792	MGI
involved in synaptic vesicle clustering	IDA IDA: Inferred from direct assay	32075774	MGI
involved in synaptic vesicle clustering	IMP IMP: Inferred from mutant phenotype	32075774	MGI
involved in synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	32075774	MGI
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	32075774	MGI
involved in white fat cell differentiation	IDA IDA: Inferred from direct assay	18483224	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	22745816	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22745816	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	32075774	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16702210	MGI
is active in presynaptic active zone cytoplasmic component	IDA IDA: Inferred from direct assay	22745816	MGI
part of transcription repressor complex	IDA IDA: Inferred from direct assay	18483224	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
C-terminal-binding protein 1

Ctbp1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Ctbp1	O88712	HIC1	Homo sapiens	Q14526	IF	12052894
Cross	Ctbp1	O88712	HIC1	Homo sapiens	Q14526	Anti Tag CoIP	12052894
Cross	Ctbp1	O88712	HIC1	Homo sapiens	Q14526	Imaging	16724116
Cross	Ctbp1	O88712	HIC1	Homo sapiens	Q14526	Anti Tag CoIP	16762039
Intra	Ctbp1	O88712	Zeb1	Mus musculus	Q64318	Anti Tag CoIP	21224849
Intra	Ctbp1	O88712	Zeb1	Mus musculus	Q64318	Anti Bait CoIP	17392792
Intra	Ctbp1	O88712	Zeb1	Mus musculus	Q64318	Anti Bait CoIP	21224849

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135046	MTOB sodium	Inhibitor	97.02%	Unkown
HY-RS03283	CTBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19426	Ctbp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25917	Ctbp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctbp1	NCBI	NCBI:1487