CP61 acetate
Based on 1 Customer Validation
CP61 acetate is a CtBP1 and CtBP2 inhibitor that binds to dimeric CtBP1 and allosterically inhibits NADH (HY-113355) binding, disrupting the NADH-dependent dimerization of CtBP1 and CtBP2, inducing aberrant mitosis and micronucleus formation, thereby inhibiting cell proliferation and colony formation. CP61 acetate can be used in breast cancer research.
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- Pureté : 98.92%
- Formule: C50H73N13O12S·xC2H4O2
- Masse moléculaire:1080.26 (free base)
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
CtBP1 |
CtBP2 |
In Vitro
CP61 acetate dose-dependently disrupts the GST-CtBP1/His-CtBP1 complex in the presence of 10 μM NADH[1].
CP61 acetate allosterically and dose-dependently reduces the CtBP1-NADH FRET signal (Trp 285 nm, NADH 425 nm), and the maximal FRET is suppressed under saturating NADH, suggesting that it does not occupy the NADH pocket[1].
CP61 acetate shows no inhibitory effect on other Rossmann fold-containing NAD+/NADH-dependent dehydrogenases at concentrations up to 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Breast Cancer Modeling
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- Soft Agar Colony Formation Assay
- MTT Cell Proliferation Assay
- Genotoxicity/Mutagenicity Study
Chemical Information
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Appearance Solid
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Masse moléculaire 1080.26 (free base)
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Formule C50H73N13O12S·xC2H4O2
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Color White to off-white
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SMILES
O=C(NCC(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCSC)C(N[C@H]3CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)NC3=O.CC(O)=O.[x]
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Sequence
cyclo(Ser-Gly-Trp-Thr-Val-Val-Arg-Met-Tyr)
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Sequence Shortening
cyclo(SGWTVVRMY)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Pureté et documentation
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Fiche technique (301 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CP61 acetate Related Classifications
HY-P10812A Related Classifications
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