2. Others
  3. Others
  4. MTOB sodium

MTOB sodium is a potent C-terminal binding protein (CtBP) inhibitor. MTOB sodium attenuates repetitive head injury-elicited neurologic dysfunction and neuroinflammation via inhibition of the transactivation activity of CtBP1 and CtBP2. MTOB sodium antagonizes the transcriptional regulatory activity of CtBP1 and CtBP2 by eviction from their target promoters in breast cancer cell lines.

For research use only. We do not sell to patients.

MTOB sodium Chemical Structure

MTOB sodium Chemical Structure

CAS No. : 51828-97-8

Size Price Stock Quantity
1 mg USD 62 In-stock
5 mg USD 212 In-stock
10 mg USD 360 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

MTOB sodium Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE MTOB sodium

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MTOB sodium is a potent C-terminal binding protein (CtBP) inhibitor. MTOB sodium attenuates repetitive head injury-elicited neurologic dysfunction and neuroinflammation via inhibition of the transactivation activity of CtBP1 and CtBP2. MTOB sodium antagonizes the transcriptional regulatory activity of CtBP1 and CtBP2 by eviction from their target promoters in breast cancer cell lines[1][2].

IC50 & Target

CtBP[1]
In Vitro

MTOB sodium (10 mM) causes significant derepression (P<0.05) of 40% of CtBP target genes (including FGF9, CTNNB1, CEBPB, et al.) in MCF-7 and 46% in MBA-MD-231; increases the pro-epithelial E-cadherin/Vimentin ratio while reducing the pro-mesenchymal CD44/CD24 ratio, with a more significant trend (P<0.05) in MCF-7[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MTOB sodium Related Antibodies
In Vivo

MTOB sodium (860 mg/kg; IP, at 1 h and 18 h after the first injury) effectively suppresses the increases duration of righting reflex, and significantly decreased neurological severity score (NSS) scores[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (traumatic brain injury)[1]
Dosage: 860 mg/kg
Administration: IP, at 1 h and 18 h after the first injury
Result: Effectively suppressed the increased duration of righting reflex, and significantly decreased NSS scores.
Molecular Weight

170.16

Formula

C5H7NaO3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])C(CCSC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (734.60 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8768 mL 29.3841 mL 58.7682 mL
5 mM 1.1754 mL 5.8768 mL 11.7536 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.24%

COA (245 KB) HNMR (227 KB) LCMS (92 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.8768 mL 29.3841 mL 58.7682 mL 146.9205 mL
5 mM 1.1754 mL 5.8768 mL 11.7536 mL 29.3841 mL
10 mM 0.5877 mL 2.9384 mL 5.8768 mL 14.6921 mL
15 mM 0.3918 mL 1.9589 mL 3.9179 mL 9.7947 mL
20 mM 0.2938 mL 1.4692 mL 2.9384 mL 7.3460 mL
25 mM 0.2351 mL 1.1754 mL 2.3507 mL 5.8768 mL
30 mM 0.1959 mL 0.9795 mL 1.9589 mL 4.8974 mL
40 mM 0.1469 mL 0.7346 mL 1.4692 mL 3.6730 mL
50 mM 0.1175 mL 0.5877 mL 1.1754 mL 2.9384 mL
60 mM 0.0979 mL 0.4897 mL 0.9795 mL 2.4487 mL
80 mM 0.0735 mL 0.3673 mL 0.7346 mL 1.8365 mL
100 mM 0.0588 mL 0.2938 mL 0.5877 mL 1.4692 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

MTOB sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MTOB51828-97-8OthersCtBPneuroinflammationtraumatic brain injuryTBIbreast cancerMBA-MD-231MCF-7Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
MTOB sodium
Cat. No.:
HY-135046
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.