51828-97-8
Chemical Structure
MTOB sodium
- CAS No.: 51828-97-8
- Formula:C5H7NaO3S
- Molecular Weight:170.16
IUPAC Name: sodium 4-(methylthio)-2-oxobutanoate
InChIKey: IFSCKRWNXKWTLR-UHFFFAOYSA-M
SMILES: O=C(O[Na])C(CCSC)=O
Biological Activity: MTOB sodium is a potent C-terminal binding protein (CtBP) inhibitor. MTOB sodium attenuates repetitive head injury-elicited neurologic dysfunction and neuroinflammation via inhibition of the transactivation activity of CtBP1 and CtBP2. MTOB sodium antagonizes the transcriptional regulatory activity of CtBP1 and CtBP2 by eviction from their target promoters in breast cancer cell lines[1][2].
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MTOB sodium | 97.02% | MTOB sodium is a potent C-terminal binding protein (CtBP) inhibitor. MTOB sodium attenuates repetitive head injury-elicited neurologic dysfunction and neuroinflammation via inhibition of the transactivation activity of CtBP1 and CtBP2. MTOB sodium antagonizes the transcriptional regulatory activity of CtBP1 and CtBP2 by eviction from their target promoters in breast cancer cell lines. | ||||||||||||||||||||
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- [1]. Li H, et al. C-terminal binding proteins 1 and 2 in traumatic brain injury-induced inflammation and their inhibition as an approach for anti-inflammatory treatment. Int J Biol Sci. 2020 Feb 4;16(7):1107-1120. [Content Brief]
- [2]. Di LJ, et al. Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer. Nat Commun. 2013;4:1449. [Content Brief]
Keywords
