2. Metabolic Enzyme/Protease
  3. Ornithine decarboxylase (ODC)
  4. 4-Methylthio-2-oxobutanoic acid

4-Methylthio-2-oxobutanoic acid (MTOB) is an ornithine decarboxylase inhibitor. 4-Methylthio-2-oxobutanoic acid reduces ornithine decarboxylase protein levels and enzymatic activity. 4-Methylthio-2-oxobutanoic acid is formed in cells in the Met salvage pathway from methylthioadenosine. 4-Methylthio-2-oxobutanoic acid inhibits cancer cells growth. 4-Methylthio-2-oxobutanoic acid can be used for the research of cancer.

For research use only. We do not sell to patients.

4-Methylthio-2-oxobutanoic acid

4-Methylthio-2-oxobutanoic acid Chemical Structure

CAS No. : 583-92-6

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4-Methylthio-2-oxobutanoic acid Related Antibodies

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2 Publications Citing Use of MCE 4-Methylthio-2-oxobutanoic acid

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  • Purity & Documentation

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  • Customer Review

Description

4-Methylthio-2-oxobutanoic acid (MTOB) is an ornithine decarboxylase inhibitor. 4-Methylthio-2-oxobutanoic acid reduces ornithine decarboxylase protein levels and enzymatic activity. 4-Methylthio-2-oxobutanoic acid is formed in cells in the Met salvage pathway from methylthioadenosine. 4-Methylthio-2-oxobutanoic acid inhibits cancer cells growth. 4-Methylthio-2-oxobutanoic acid can be used for the research of cancer[1][2].

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
4 mM
Compound: 1; MTOB
Cytotoxicity against human HCT116 p53-/- cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Cytotoxicity against human HCT116 p53-/- cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 27156192]
In Vitro

4-Methylthio-2-oxobutanoic acid (0.1 mM; 24 h) represses elevated ornithine decarboxylase protein levels in MTAP-deleted Saccharomyces cerevisiae strains (meu1Δ, E1, E2)[1].
4-Methylthio-2-oxobutanoic acid (0.2-2 mM; 24 h) represses ornithine decarboxylase activity in MTAP-deleted MCF-7 breast adenocarcinoma and MIA PaCa-2 pancreatic adenocarcinoma cells[1].
4-Methylthio-2-oxobutanoic acid (3 days) inhibits HeLa epithelial cell growth with an IC50 of 1.6 mM[2].
4-Methylthio-2-oxobutanoic acid (200-800 μM; 8 h) does not induce DNA fragmentation and DNA double-strand breaks in BAF3 murine lymphoid cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4-Methylthio-2-oxobutanoic acid Related Antibodies

Western Blot Analysis[2]

Cell Line: BAF3 murine lymphoid cells
Concentration: 0.1 mM
Incubation Time: 24 h
Result: Reduced ornithine decarboxylase protein levels.
Molecular Weight

148.18

Formula

C5H8O3S
CAS No.
SMILES

O=C(O)C(CCSC)=O
Structure Classification
Initial Source
Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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4-Methylthio-2-oxobutanoic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Methylthio-2-oxobutanoic acid583-92-6MTOBOrnithine decarboxylase (ODC)Ornithine Decarboxylasebreast adenocarcinomamethioninemethionalpolyamine biosynthesismethionine salvage pathwaymethylthioadenosineyeast strainsbranched chain oxo-acid dehydrogenase complexhuman cancer cellsornithine decarboxylaseInhibitorinhibitorinhibit

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