4-Methylthio-2-oxobutanoic acid
Based on 2 publication(s) in Google Scholar
4-Methylthio-2-oxobutanoic acid (MTOB) is an ornithine decarboxylase inhibitor. 4-Methylthio-2-oxobutanoic acid reduces ornithine decarboxylase protein levels and enzymatic activity. 4-Methylthio-2-oxobutanoic acid is formed in cells in the Met salvage pathway from methylthioadenosine. 4-Methylthio-2-oxobutanoic acid inhibits cancer cells growth. 4-Methylthio-2-oxobutanoic acid can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 583-92-6
- Formula: C5H8O3S
- Molecular Weight:148.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) 4-Methylthio-2-oxobutanoic acid
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
4 mM
Compound: 1; MTOB
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Cytotoxicity against human HCT116 p53-/- cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Cytotoxicity against human HCT116 p53-/- cells assessed as inhibition of cell growth after 72 hrs by MTT assay
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[PMID: 27156192] |
4-Methylthio-2-oxobutanoic acid (0.1 mM; 24 h) represses elevated ornithine decarboxylase protein levels in MTAP-deleted Saccharomyces cerevisiae strains (meu1Δ, E1, E2)[1].
4-Methylthio-2-oxobutanoic acid (0.2-2 mM; 24 h) represses ornithine decarboxylase activity in MTAP-deleted MCF-7 breast adenocarcinoma and MIA PaCa-2 pancreatic adenocarcinoma cells[1].
4-Methylthio-2-oxobutanoic acid (3 days) inhibits HeLa epithelial cell growth with an IC50 of 1.6 mM[2].
4-Methylthio-2-oxobutanoic acid (200-800 μM; 8 h) does not induce DNA fragmentation and DNA double-strand breaks in BAF3 murine lymphoid cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BAF3 murine lymphoid cells
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Concentration:0.1 mM
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Incubation Time:24 h
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Result:Reduced ornithine decarboxylase protein levels.
Chemical Information
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CAS No. 583-92-6
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Molecular Weight 148.18
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Formula C5H8O3S
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SMILES
O=C(O)C(CCSC)=O
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Synonyms
MTOB
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Biol Direct
PNSC928, a plant-derived compound, specifically disrupts CtBP2-p300 interaction and reduces inflammation in mice with acute respiratory distress syndrome. [Abstract]2024 Jun 21;19(1):48. PMID: 38902802 -
Cytokine
Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion. [Abstract]2024 Jan:173:156436. PMID: 37979214
Purity & Documentation
References
[1]. Subhi AL, et al. Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites. J Biol Chem. 2003;278(50):49868-49873. [Content Brief]
[2]. Quash G, et al. Methional derived from 4-methylthio-2-oxobutanoate is a cellular mediator of apoptosis in BAF3 lymphoid cells. Biochem J. 1995;305 ( Pt 3)(Pt 3):1017-1025. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-Methylthio-2-oxobutanoic acid Related Classifications
HY-23964 Related Classifications
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- 4-Methylthio-2-oxobutanoic acid
- 583-92-6
- MTOB
- Ornithine decarboxylase (ODC)
- breast adenocarcinoma
- methionine
- methional
- polyamine biosynthesis
- methionine salvage pathway
- methylthioadenosine
- yeast strains
- branched chain oxo-acid dehydrogenase complex
- human cancer cells
- ornithine decarboxylase
- Inhibitor
- inhibitor
- inhibit