583-92-6
Chemical Structure
4-Methylthio-2-oxobutanoic acid
Synonym(s): MTOB
- CAS No.: 583-92-6
- Formula:C5H8O3S
- Molecular Weight:148.18
IUPAC Name: 4-(methylthio)-2-oxobutanoic acid
InChIKey: SXFSQZDSUWACKX-UHFFFAOYSA-N
SMILES: O=C(O)C(CCSC)=O
Biological Activity: 4-Methylthio-2-oxobutanoic acid (MTOB) is an ornithine decarboxylase inhibitor. 4-Methylthio-2-oxobutanoic acid reduces ornithine decarboxylase protein levels and enzymatic activity. 4-Methylthio-2-oxobutanoic acid is formed in cells in the Met salvage pathway from methylthioadenosine. 4-Methylthio-2-oxobutanoic acid inhibits cancer cells growth. 4-Methylthio-2-oxobutanoic acid can be used for the research of cancer[1][2].
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4-Methylthio-2-oxobutanoic acid | 4-Methylthio-2-oxobutanoic acid (MTOB) is an ornithine decarboxylase inhibitor. 4-Methylthio-2-oxobutanoic acid reduces ornithine decarboxylase protein levels and enzymatic activity. 4-Methylthio-2-oxobutanoic acid is formed in cells in the Met salvage pathway from methylthioadenosine. 4-Methylthio-2-oxobutanoic acid inhibits cancer cells growth. 4-Methylthio-2-oxobutanoic acid can be used for the research of cancer. | |||||||||||||||||||||
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- [1]. Subhi AL, et al. Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites. J Biol Chem. 2003;278(50):49868-49873. [Content Brief]
- [2]. Quash G, et al. Methional derived from 4-methylthio-2-oxobutanoate is a cellular mediator of apoptosis in BAF3 lymphoid cells. Biochem J. 1995;305 ( Pt 3)(Pt 3):1017-1025. [Content Brief]
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