CTBP2 - C-terminal binding protein 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1488

About CTBP2

Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:124,984,317-125,162,463 (from NCBI)

This gene has 14 transcripts (splice variants), 200 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 13.6), endometrium (RPKM 9.4) and 24 other tissues.

Summary

This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the Other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

CTBP2 Products (9)

mRNA	Protein	Name
NM_001083914.3	NP_001077383.1	C-terminal-binding protein 2 isoform 1
NM_001290214.3	NP_001277143.1	C-terminal-binding protein 2 isoform 1
NM_001290215.3	NP_001277144.1	C-terminal-binding protein 2 isoform 1
NM_001321012.2	NP_001307941.1	C-terminal-binding protein 2 isoform 1
NM_001321013.2	NP_001307942.1	C-terminal-binding protein 2 isoform 1
NM_001321014.2	NP_001307943.1	C-terminal-binding protein 2 isoform 1
NM_001329.4	NP_001320.1	C-terminal-binding protein 2 isoform 1
NM_001363508.2	NP_001350437.1	C-terminal-binding protein 2 isoform 3
NM_022802.3	NP_073713.2	C-terminal-binding protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	23393140	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	23393140	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	29628311	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within positive regulation of retinoic acid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23775127	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23775127	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	16702210	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTBP2 Protein Structure

2-Hacid_dh

2-Hacid_dh_C

0
100
200
300
400
445 a.a.

Protein Preferred Names	Protein Names
C-terminal-binding protein 2	ribeye

CTBP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CTBP2	P56545	CTBP1	Homo sapiens	Q13363-2	Y2H Array	25416956
Intra	CTBP2	P56545	CTBP1	Homo sapiens	Q13363-2	BFG-2H	27107012
Intra	CTBP2	P56545	NOL4	Homo sapiens	O94818-2	Validated Y2H	25416956
Intra	CTBP2	P56545	ZNF750	Homo sapiens	Q32MQ0	Y2H Prey Pooling	25416956
Intra	CTBP2	P56545	ZNF750	Homo sapiens	Q32MQ0	Validated Y2H	25416956
Intra	CTBP2	P56545	ZNF750	Homo sapiens	Q32MQ0	Y2H Array	25416956
Intra	CTBP2	P56545	HIC1	Homo sapiens	Q14526	Anti Bait CoIP	19486893
Intra	CTBP2	P56545	ZNF516	Homo sapiens	Q92618	Anti Tag CoIP	35271311
Intra	CTBP2	P56545	FUNDC1	Homo sapiens	Q8IVP5	Validated Y2H	25416956
Intra	CTBP2	P56545	FUNDC1	Homo sapiens	Q8IVP5	Y2H Prey Pooling	25416956
Intra	CTBP2	P56545	PLCB1	Homo sapiens	Q9NQ66	Y2H Prey Pooling	25416956
Intra	CTBP2	P56545	PLCB1	Homo sapiens	Q9NQ66	Validated Y2H	25416956
Intra	CTBP2	P56545	IKZF2	Homo sapiens	Q9UKS7	Validated Y2H	25416956
Intra	CTBP2	P56545	IKZF2	Homo sapiens	Q9UKS7	Y2H Prey Pooling	25416956
Intra	CTBP2	P56545	PROX1	Homo sapiens	Q92786	Anti Tag CoIP	21988832
Cross	CTBP2	P56545	Zbp1	Mus musculus	A2APF7	Anti Tag CoIP	21903422
Intra	CTBP2	P56545	NOL4L	Homo sapiens	Q96MY1	Y2H Array	25416956
Intra	CTBP2	P56545	NOL4L	Homo sapiens	Q96MY1	Anti Tag CoIP	35271311
Intra	CTBP2	P56545	TGIF1	Homo sapiens	Q15583	Y2H Pooling	16189514
Intra	CTBP2	P56545	TGIF1	Homo sapiens	Q15583	Y2H Array	25416956
Intra	CTBP2	P56545	TGIF1	Homo sapiens	Q15583	Y2H	21516116
Intra	CTBP2	P56545	PPP1R15A	Homo sapiens	O75807	Anti Tag CoIP	21988832
Intra	CTBP2	P56545	PPP1R15A	Homo sapiens	O75807	Y2H	21988832
Intra	CTBP2	P56545	FHL3	Homo sapiens	Q13643	Validated Y2H	27107012
Intra	CTBP2	P56545	CCNH	Homo sapiens	P51946	Confocal	21988832
Intra	CTBP2	P56545	CCNH	Homo sapiens	P51946	Pull Down	21988832
Intra	CTBP2	P56545	IKZF1	Homo sapiens	Q13422	Validated Y2H	25416956
Intra	CTBP2	P56545	IKZF1	Homo sapiens	Q13422	Y2H	21516116
Intra	CTBP2	P56545	LCOR	Homo sapiens	Q96JN0	Y2H Array	31515488
Intra	CTBP2	P56545	LCOR	Homo sapiens	Q96JN0	Y2H Prey Pooling	25416956
Intra	CTBP2	P56545	LCOR	Homo sapiens	Q96JN0	Anti Tag CoIP	35271311
Intra	CTBP2	P56545	LCOR	Homo sapiens	Q96JN0	Validated Y2H	25416956
Intra	CTBP2	P56545	RAI2	Homo sapiens	Q9Y5P3	Y2H Prey Pooling	25416956
Intra	CTBP2	P56545	RAI2	Homo sapiens	Q9Y5P3	Y2H Array	25416956
Intra	CTBP2	P56545	RAI2	Homo sapiens	Q9Y5P3	Y2H Pooling	16189514
Intra	CTBP2	P56545	CTBP1	Homo sapiens	Q13363	Anti Tag CoIP	35271311
Intra	CTBP2	P56545	CTBP1	Homo sapiens	Q13363	Y2H	21988832
Intra	CTBP2	P56545	CTBP1	Homo sapiens	Q13363	Y2H Array	31515488
Intra	CTBP2	P56545	CTBP1	Homo sapiens	Q13363	Anti Bait CoIP	36414381
Intra	CTBP2	P56545	BCL3	Homo sapiens	P20749	Y2H	21988832
Intra	CTBP2	P56545	FOXP2	Homo sapiens	O15409	Y2H Array	25416956
Intra	CTBP2	P56545	FOXP2	Homo sapiens	O15409	Y2H Prey Pooling	25416956
Intra	CTBP2	P56545	FOXP2	Homo sapiens	O15409	Y2H Pooling	21653829

Cross: Cross-species interaction Intra: Intraspecies interaction

CTBP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83090	CTBP2 Antibody (YA2835)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P83090A	CTBP2 Antibody (YA2835)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
46,Xy Sex Reversal 9	SRXY9 46,Xy Sex Reversal, Zfpm2-Related 46xy Sex Reversal 9
Developmental And Epileptic Encephalopathy 75	DEE75 Epileptic Encephalopathy, Early Infantile, 75 Eiee75 Developmental And Epileptic Encephalopathy, 75 Early Infantile Epileptic Encephalopathy 75
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Congenital Stationary Night Blindness	Night Blindness, Congenital Stationary Congenital Essential Nyctalopia Oguchi Disease Blindness, Night, Stationary, Congenital
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135046	MTOB sodium	Inhibitor	97.02%	Unkown
HY-RS03284	CTBP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20897	Ctbp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27414	Ctbp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CTBP2	VGNC	VGNC:61243
Canis familiaris	CTBP2	VGNC	VGNC:39687
Mus musculus	CTBP2	MGD	MGI:1201686
Rattus norvegicus	CTBP2	RGD	RGD:68372
Macaca mulatta	CTBP2	VGNC	VGNC:103803
Bos taurus	CTBP2	VGNC	VGNC:55942
Others	CTBP2	NCBI