IKZF2 - IKAROS family zinc finger 2 Gene

Homo sapiens

Also known as ANF1A2; HELIOS; ZNF1A2; ZNFN1A2

Gene ID: 22807 | Gene type: protein coding

About IKZF2

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:212,999,698-213,152,456 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues and 11 paralogues. Broad expression in esophagus (RPKM 4.7), urinary bladder (RPKM 3.1) and 21 other tissues.

Summary

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

IKZF2 Products(7)

mRNA	Protein	Name
NM_001079526.2	NP_001072994.1	zinc finger protein Helios isoform 2
NM_001371274.1	NP_001358203.1	zinc finger protein Helios isoform 1
NM_001371275.1	NP_001358204.1	zinc finger protein Helios isoform 2
NM_001371276.1	NP_001358205.1	zinc finger protein Helios isoform 2
NM_001371277.1	NP_001358206.1	zinc finger protein Helios isoform 3
NM_001387220.1	NP_001374149.1	zinc finger protein Helios isoform 1
NM_016260.3	NP_057344.2	zinc finger protein Helios isoform 1

IKZF2 Protein Structure

zf-H2C2_2

0
100
200
300
400
526 a.a.

Protein Preferred Names

Protein Names

zinc finger protein Helios

ikaros family zinc finger protein 2

Related Diseases

Diseases

Alias

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Dermatitis, Atopic, 7

ATOD7	Dermatitis, Atopic, Susceptibility To, 7
Atopic Dermatitis 7	Dermatitis, Atopic 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145776	ALV1		95.15%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-144998	NVP-DKY709	Inhibitor	98.98%	Unkown
HY-157334	DEG-77		98.31%	Unkown
HY-RS06666	IKZF2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IKZF2	RGD	RGD:1308686
Felis catus	IKZF2	VGNC	VGNC:80245
Canis familiaris	IKZF2	VGNC	VGNC:41924
Macaca mulatta	IKZF2	VGNC	VGNC:73586
Bos taurus	IKZF2	VGNC	VGNC:56125
Mus musculus	IKZF2	MGD	MGI:1342541

Name
Email *

	Sorry, but the email address you supplied was invalid.