IKZF2-degrader 4
IKZF2-degrader 4 (Page 650, third compound from the top in the right column) is an IKZF2 Molecular glue degrader. IKZF2-degrader 4 degrades IKZF2 protein. IKZF2-degrader 4 can be used in the research of cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 2989880-79-5
- Formule: C32H39N3O3
- Masse moléculaire:513.67
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
IKZF2 |
In Vitro
IKZF2 (IKAROS family zinc finger 2), also known as Helios, is a member of the Ikaros zinc finger protein family. It is a transcription factor specifically highly expressed in regulatory T cells (Tregs), crucial for maintaining Treg function and stability, thereby suppressing anti-tumor immune responses.
Molecular glue degraders are small molecules that induce novel protein-protein interactions between target proteins and E3 ubiquitin ligases. They trigger ubiquitination and proteasome degradation of target proteins by forming ternary complexes.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2989880-79-5
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Masse moléculaire 513.67
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Formule C32H39N3O3
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SMILES
O=C1C2=CC=C(C[C@@H]3[C@H](CCCC3)NC4CCC(C5=CC=CC=C5)CC4)C=C2CN1C6C(NC(CC6)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Polyacrylamide gel electrophoresis (PAGE) (<1 kb)
Gel electrophoresis is a method for separating biological macromolecules (such as nucleic acids or proteins) by forcing them through a gel matrix under an electric field.
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Protocol for Protein Electrophoresis
Protein electrophoresis separates proteins in a polyacrylamide gel under an electric field; in SDS-PAGE, sodium dodecyl sulfate denatures proteins and gives them a broadly similar negative charge-to-mass ratio, so migration mainly reflects apparent molecular mass through the gel matrix. The readout is a stained protein band pattern: band position estimates apparent molecular mass using protein standards, band intensity reflects relative protein abundance within the linear range of staining/detection, and changes in band pattern can reflect protein expression, degradation, purification, or sample composition.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IKZF2-degrader 4 Related Classifications
HY-185300 Related Classifications
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