IKZF-IN-1
IKZF-IN-1 is a molecular glue and an IKZF protein degrader that mediates the degradation of IKZF1/IKZF2/IKZF3/IKZF4 proteins. IKZF-IN-1 promotes the ubiquitination of target proteins via the CUL4‑CRBN E3 ubiquitin ligase complex, thereby triggering the degradation of target proteins. IKZF-IN-1 can be used in cancer-related research.
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- Formule: C26H28FN5O4
- Masse moléculaire:493.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
IKZF1 |
IZKF2 |
IKZF3 |
IKZF4 |
In Vitro
IKZF-IN-1 exhibits an IKZF1 DC50 of >10 000 nM with a maximum degradation rate of 49%, and an IKZF2 DC50 of 10 nM with a maximum degradation rate of 100% in human regulatory T cell degradation assays[1].
IKZF-IN-1 exhibits a DC50 of 38 nM for IKZF2 and 3.4 nM for IKZF4 in the human regulatory T cell reprogramming assay, with maximum degradation rates of 85% and 65%, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 493.53
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Formule C26H28FN5O4
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SMILES
O=C1N(C2C(NC(CC2)=O)=O)CC3=C(F)C(C4=CC=C(CN5CC6(CCCOC6)C5)C(N)=N4)=CC=C31
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IKZF-IN-1 Related Classifications
HY-170518 Related Classifications
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