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Cat. No.: HY-170518

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IKZF-IN-1

IKZF-IN-1 is a molecular glue and an IKZF protein degrader that mediates the degradation of IKZF1/IKZF2/IKZF3/IKZF4 proteins. IKZF-IN-1 promotes the ubiquitination of target proteins via the CUL4‑CRBN E3 ubiquitin ligase complex, thereby triggering the degradation of target proteins. IKZF-IN-1 can be used in cancer-related research.

For research use only. We do not sell to patients.

Formula: C₂₆H₂₈FN₅O₄
Molecular Weight:493.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

IKZF-IN-1 Chemical Structure

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

IKZF1

IZKF2

IKZF3

IKZF4

All IKZF Family Isoforms :

In Vitro

IKZF-IN-1 (Compound I) exhibits DC₅₀ values of 6 443 nM, 8.5 nM, and >10 000 nM against IKZF1, IKZF2, and IKZF3, respectively, in the Jurkat cell assay system, with corresponding maximum degradation rates of 53%, 91%, and 33%^[1].
IKZF-IN-1 exhibits an IKZF1 DC₅₀ of >10 000 nM with a maximum degradation rate of 49%, and an IKZF2 DC₅₀ of 10 nM with a maximum degradation rate of 100% in human regulatory T cell degradation assays^[1].

IKZF-IN-1 exhibits a DC₅₀ of 38 nM for IKZF2 and 3.4 nM for IKZF4 in the human regulatory T cell reprogramming assay, with maximum degradation rates of 85% and 65%, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 493.53
Formula C₂₆H₂₈FN₅O₄
SMILES

O=C1N(C2C(NC(CC2)=O)=O)CC3=C(F)C(C4=CC=C(CN5CC6(CCCOC6)C5)C(N)=N4)=CC=C31
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cherney E C, et al. Spirocyclic substituted oxoisoindolinyl piperidine‑2,6‑dione compound. WO2024254227A1, WIPO, 2024.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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IKZF-IN-1

All IKZF Family Isoforms