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Cat. No.: HY-177754

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IKZF2-degrader 3

IKZF2-degrader 3 (compound 6) is a molecular glue IKZF2 degrader with a DC₅₀ of 2.0 nM.

For research use only. We do not sell to patients.

CAS No.: 2983841-46-7
Formula: C₂₄H₂₄N₆O₃
Molecular Weight:444.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

IKZF2-degrader 3 Chemical Structure

CAS No.: 2983841-46-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IKZF2-degrader 3 (compound 6) is a molecular glue IKZF2 degrader with a DC₅₀ of 2.0 nM^[1].

IC₅₀ & Target^[1]

IZKF2

2.0 nM (DC₅₀)

All IKZF Family Isoforms :

Chemical Information

CAS No. 2983841-46-7
Molecular Weight 444.49
Formula C₂₄H₂₄N₆O₃
SMILES

O=C1CCC(C(N1)=O)N2CC3=CC(C4=CC(CN5CCCC5)=C6C(C=NN6)=N4)=CC=C3C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang X, et al. Overcoming CK1α liability in the discovery of a series of isoIndolinone Glutarimides as selective IKZF2 molecular glue degraders. Bioorg Med Chem Lett. 2025 Aug 15;124:130263. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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