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Cat. No.: HY-182799

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IBA-12

IBA-12 is a IKZF2 molecular glue/PROTAC degrader with a DC₅₀ of 276.2 nM (Jurkat cells) and 461.8 nM (Mino cells), and an IC₅₀ of 179.9 nM. IBA-12 binds to the canonical tryptophan triad pocket of CRBN to form a ternary complex with IKZF2. IBA-12 induces IKZF2 degradation mediated by the CRBN-dependent ubiquitin-proteasome system, with no effect on other CRBN substrates. IBA-12 induces the production of interleukin-2 (IL-2) through degrading IKZF2. IBA-12 is applicable to cancer immunology research.
(Pink: IZKF2 ligand (HY-Y1863); Blue: Cereblon ligand (HY-182807); Black: linker).

For research use only. We do not sell to patients.

Formula: C₂₄H₂₅ClN₄O₃
Molecular Weight:452.93

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IBA-12 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IBA-12 is a IKZF2 molecular glue/PROTAC degrader with a DC₅₀ of 276.2 nM (Jurkat cells) and 461.8 nM (Mino cells), and an IC₅₀ of 179.9 nM. IBA-12 binds to the canonical tryptophan triad pocket of CRBN to form a ternary complex with IKZF2. IBA-12 induces IKZF2 degradation mediated by the CRBN-dependent ubiquitin-proteasome system, with no effect on other CRBN substrates. IBA-12 induces the production of interleukin-2 (IL-2) through degrading IKZF2. IBA-12 is applicable to cancer immunology research^[1]. (Pink: IZKF2 ligand (HY-Y1863); Blue: Cereblon ligand (HY-182807); Black: linker).

IC₅₀ & Target^[1]

IKZF2

276.2 nM (DC₅₀)

Cereblon

All PROTACs Isoforms :

All IKZF Family Isoforms :

In Vitro

IBA-12 (0-1000 nM; 24 h) dose-dependently increases IL-2 production in stimulated Jurkat cells, confirming functional modulation of the IKZF2-regulated transcriptional pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

stimulated Jurkat cells
Concentration:

0, 10, 100, 1000 and 1000 nM
Incubation Time:

24 h
Result:

Induced dose-dependent increases in IL-2 production.
Showed statistically significant increases observed at 100 and 1000 nM.

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC_0-t	MRT_0-∞	F	V_ss	CL
Rat^[1]	2 mg/kg	i.v.	2.68 h	0.194 h	1359 ng/mL	3748	2.39 h	/	1.27 L/kg	8.87 mL/min/kg
Rat^[1]	10 mg/kg	p.o.	2.49 h	0.667 h	2540 ng/mL	8339	2.57 h	44.5 %	/	/

Chemical Information

Molecular Weight 452.93
Formula C₂₄H₂₅ClN₄O₃
SMILES

O=C1CCC(N2NC(C=C(C3CCN(CC4=CC(Cl)=CC=C4)CC3)C=C5)=C5C2=O)C(N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nie HJ, et al. Indazolone-Based Molecular Glue Degraders as a Tunable Platform for Reprogramming Cereblon Substrate Specificity. bioRxiv. 2026 Mar 17:2026-03.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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IBA-12

All PROTACs Isoforms

All IKZF Family Isoforms