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BCL3 - BCL3 transcription coactivator Gene

Also Known as BCL4; D19S37

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 602

About BCL3

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:44,747,705-44,760,044 (from NCBI)

This gene has 9 transcripts (splice variants), 173 orthologues, 16 paralogues and is associated with 52 phenotypes. Ubiquitous expression in bone marrow (RPKM 8.4), small intestine (RPKM 7.7) and 24 other tissues.

Summary

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]

BCL3 Products (1)

mRNA	Protein	Name
NM_005178.5	NP_005169.2	B-cell lymphoma 3 protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	8196632	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	16306601	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10362352	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	16306601	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	16306601	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	16384933	GOA
involved in DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	16384933	GOA
involved in canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	8196632	GOA
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	16384933	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16306601	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	16306601	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	16384933	GOA
involved in negative regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	16306601	GOA
involved in negative regulation of receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	16306601	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16384933	GOA
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	16384933	GOA
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	8196632	GOA
involved in regulation of DNA binding	IEP IEP: Inferred from expression pattern	9407099	GOA
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	16732314	GOA
involved in regulation of non-canonical NF-kappaB signal transduction	IEP IEP: Inferred from expression pattern	8196632	GOA
involved in response to UV-C	IDA IDA: Inferred from direct assay	16384933	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	16306601	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Bcl3-Bcl10 complex	IDA IDA: Inferred from direct assay	16280327	GOA
part of Bcl3/NF-kappaB2 complex	IDA IDA: Inferred from direct assay	9407099	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11387332	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8196632	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	16280327	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCL3 Protein Structure

Ank

Ank_2

0
100
200
300
400
454 a.a.

Protein Preferred Names	Protein Names
B-cell lymphoma 3 protein	B cell CLL/lymphoma 3

BCL3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BCL3	P20749	LCK	Homo sapiens	P06239	Pull Down	16099425
Intra	BCL3	P20749	CTBP2	Homo sapiens	P56545	Anti Tag CoIP	21988832
Intra	BCL3	P20749	BCL10	Homo sapiens	O95999	Pull Down	16280327
Intra	BCL3	P20749	BCL10	Homo sapiens	O95999	Anti Bait CoIP	16280327

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Leukemia, Chronic Lymphocytic 2	Leukemia, Chronic Lymphocytic, Susceptibility To, 2 B-Cell Malignancy, Low-Grade Clls2 Disrupted In B-Cell Malignancy Dbm Leukemia, Chronic Lymphocytic, B-Cell Bcll Lymphocytic Leukemia Chronic B-Cell Chronic Lymphocytic Leukemia Chronic Lymph Leukaemia Chronic Lymphatic Leukaemia Chronic Lymphocytic Leukaemia Chronic Lymphoid Leukaemia Lymphoplasmacytic Leukaemia
Chromosomal Triplication	Trisomy
Anaplastic Large Cell Lymphoma	Alcl Cd30 Positive Anaplastic Large Cell Lymphoma Ki-1 Positive Anaplastic Large Cell Lymphoma Primary Systemic Alcl Sacl Ki-1+ Anaplastic Large Cell Lymphoma
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Peripheral T-Cell Lymphoma	Lymphoma T-Cell Peripheral

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111152	ML115	Agonist	99.98%	Unkown
HY-152177	JS6	Inhibitor	99.49%	Unkown
HY-14454	TPh A		99.75%	Unkown
HY-RS01437	BCL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18602	Bcl3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25087	Bcl3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BCL3	MGD	MGI:88140
Rattus norvegicus	BCL3	RGD	RGD:1589465
Felis catus	BCL3	VGNC	VGNC:69302
Macaca mulatta	BCL3	VGNC	VGNC:108478
Canis familiaris	BCL3	VGNC	VGNC:59228
Bos taurus	BCL3	VGNC	VGNC:58663
Others	BCL3	NCBI