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TPh A (Synonyms: Triphenyl Compound A)

Cat. No.: HY-14454
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TPh A (Triphenyl Compound A) is a potent inhibitor of the nuclear protein pirin and binds specifically to pirin with a Ki of 0.6 uM. TPh A disrupts the formation of the bcl3–pirin complex. TPh A can be used as a novel small molecule tool to regulate pirin in cells.

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TPh A Chemical Structure

TPh A Chemical Structure

CAS No. : 21306-65-0

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Description

TPh A (Triphenyl Compound A) is a potent inhibitor of the nuclear protein pirin and binds specifically to pirin with a Ki of 0.6 uM. TPh A disrupts the formation of the bcl3–pirin complex. TPh A can be used as a novel small molecule tool to regulate pirin in cells[1].

In Vitro

The Pirin is a nuclear protein with the nuclear factor I/CCAAT box transcription factor (NFI/CTF). Pirin proteins are highly conserved between mammals, plants, fungi, and prokaryotic organisms and are considered to belong to the cupin superfamily.
TPh A (20 μM; 5 hours) reduces the amount of pirin-bound Bcl3 and inhibits the interaction between pirin and Bcl3 in HEK293T cells in a glutathione S-transferase (GST) pulldown assay (HEK293T cells are transfected with vectors that encoded bcl3-Myc and pirin-His6 for 43 h of transfection)[1].
TPh A (0-100 μM; 48 hours) does not exert any potent cytotoxic activity against many human cancer cell lines, it against MCF7, MDA-MB231, HeLa, DU145, HepG2, A549, HT1080, WM266-4, and SK-MEL-28 cells with IC50 values >50 μM, and exhibits IC50 values of 27 μM, 20 μM and 26 μM for PC3 HL60 and HT29 cells, respectively[1].
TPhA (0-50 μM; 48 hours) inhibits cell migration in WM266-4 cells, SK-MEL-28 cell in a concentration-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MCF7, MDA-MB231, HeLa, DU145, HepG2, A549, HT1080, WM266-4, and SK-MEL-28 cells
Concentration: 0-100 μM
Incubation Time: 48 hours
Result: Did not exert any potent cytotoxic activity against many human cancer cell lines.
Molecular Weight

399.53

Formula

C₂₁H₂₁NO₃S₂

CAS No.

21306-65-0

SMILES

O=[S](/N=[S](C(C=C1)=CC=C1OCC2=CC=CC=C2)\C)(C(C=C3)=CC=C3C)=O

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Keywords:

TPh ATriphenyl Compound AOthersmelanoma cellpirinWM266-4SK-MEL-28MDA-MB231HeLaDU145HepG2A549HT1080Melanomacell migrationInhibitorinhibitorinhibit

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TPh A
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