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RAI2 - retinoic acid induced 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10742

About RAI2

Cytogenetic location: Xp22.13 Genomic coordinates (GRCh38): X:17,800,049-17,861,298 (from NCBI)

This gene has 6 transcripts (splice variants), 169 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 19.5), ovary (RPKM 15.2) and 23 other tissues.

Summary

Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this retinoic acid-induced gene has not yet been determined but it may play a role in development. The chromosomal location of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked cognitive disability, oral-facial-digital syndrome, and Fried syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

RAI2 Products (4)

mRNA	Protein	Name
NM_001172732.2	NP_001166203.2	retinoic acid-induced protein 2 isoform 2
NM_001172739.2	NP_001166210.2	retinoic acid-induced protein 2 isoform 1
NM_001172743.2	NP_001166214.2	retinoic acid-induced protein 2 isoform 1
NM_021785.6	NP_068557.4	retinoic acid-induced protein 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAI2 Protein Structure

SOBP

0
100
200
300
400
500
530 a.a.

Protein Preferred Names	Protein Names
retinoic acid-induced protein 2

RAI2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAI2	Q9Y5P3	CTBP2	Homo sapiens	P56545-3	Validated Y2H	25416956
Intra	RAI2	Q9Y5P3	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	RAI2	Q9Y5P3	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	RAI2	Q9Y5P3	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Intra	RAI2	Q9Y5P3	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	RAI2	Q9Y5P3	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	RAI2	Q9Y5P3	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	RAI2	Q9Y5P3	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	RAI2	Q9Y5P3	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	RAI2	Q9Y5P3	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	RAI2	Q9Y5P3	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	RAI2	Q9Y5P3	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	RAI2	Q9Y5P3	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	RAI2	Q9Y5P3	FHL2	Homo sapiens	Q14192	Y2H Array	31515488
Intra	RAI2	Q9Y5P3	FHL2	Homo sapiens	Q14192	Y2H Prey Pooling	25416956
Intra	RAI2	Q9Y5P3	UBQLN4	Homo sapiens	Q9NRR5	Y2H Array	16713569
Intra	RAI2	Q9Y5P3	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	RAI2	Q9Y5P3	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	RAI2	Q9Y5P3	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	RAI2	Q9Y5P3	CTBP2	Homo sapiens	P56545	Validated Y2H	25416956
Intra	RAI2	Q9Y5P3	SGTB	Homo sapiens	Q96EQ0	Y2H Array	29892012
Intra	RAI2	Q9Y5P3	SGTB	Homo sapiens	Q96EQ0	Y2H Pooling	16189514
Intra	RAI2	Q9Y5P3	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	25416956
Intra	RAI2	Q9Y5P3	SGTB	Homo sapiens	Q96EQ0	Y2H Array	25416956
Intra	RAI2	Q9Y5P3	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	RAI2	Q9Y5P3	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	RAI2	Q9Y5P3	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Nance-Horan Syndrome	NHS Cataract-Dental Syndrome Cataract, X-Linked, With Hutchinsonian Teeth Mesiodens-Cataract Syndrome Cataract X-Linked With Hutchinsonian Teeth Cataract Dental Syndrome Mesiodens Cataract Syndrome
Decubitus Ulcer	Pressure Ulcer Pressure Sores Pressure Ulcers Bedsore Decubitus Ulcer Decubitus Ulcer Any Site
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11626	RAI2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RAI2	MGD	MGI:1344378
Macaca mulatta	RAI2	VGNC	VGNC:76652
Rattus norvegicus	RAI2	RGD	RGD:1560139
Bos taurus	RAI2	VGNC	VGNC:33697
Felis catus	RAI2	VGNC	VGNC:69225
Others	RAI2	NCBI