FHL3 - four and a half LIM domains 3 Gene

Also Known as SLIM2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2275

About FHL3

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:37,996,770-38,005,514 (from NCBI)

This gene has 5 transcripts (splice variants), 285 orthologues and 2 paralogues. Ubiquitous expression in esophagus (RPKM 21.3), endometrium (RPKM 16.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the Cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

FHL3 Products (2)

mRNA	Protein	Name
NM_001243878.2	NP_001230807.1	four and a half LIM domains protein 3 isoform 2
NM_004468.5	NP_004459.2	four and a half LIM domains protein 3 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FHL3 Protein Structure

LIM

0
100
200
280 a.a.

Protein Preferred Names	Protein Names
four and a half LIM domains protein 3	FHL-3

FHL3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FHL3	Q13643	DCDC2B	Homo sapiens	A2VCK2	Validated Y2H	25416956
Intra	FHL3	Q13643	KRTAP12-2	Homo sapiens	P59991	Validated Y2H	25416956
Intra	FHL3	Q13643	KRTAP12-2	Homo sapiens	P59991	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	TRO	Homo sapiens	G5E9N2	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	TRO	Homo sapiens	G5E9N2	Validated Y2H	25416956
Intra	FHL3	Q13643	TRO	Homo sapiens	G5E9N2	Y2H Array	25416956
Intra	FHL3	Q13643	GCM2	Homo sapiens	O75603	Y2H Array	29892012
Intra	FHL3	Q13643	GCM2	Homo sapiens	O75603	Y2H Array	31515488
Intra	FHL3	Q13643	GCM2	Homo sapiens	O75603	Validated Y2H	25416956
Intra	FHL3	Q13643	GCM2	Homo sapiens	O75603	Y2H Array	25416956
Intra	FHL3	Q13643	KRTAP12-1	Homo sapiens	P59990	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	KRTAP12-1	Homo sapiens	P59990	Y2H Array	25416956
Intra	FHL3	Q13643	KRTAP12-1	Homo sapiens	P59990	Validated Y2H	25416956
Intra	FHL3	Q13643	CCDC198	Homo sapiens	Q9NVL8	Validated Y2H	25416956
Intra	FHL3	Q13643	TSGA10IP	Homo sapiens	Q3SY00	Validated Y2H	32296183
Intra	FHL3	Q13643	PIERCE1	Homo sapiens	Q5BN46	Validated Y2H	25416956
Intra	FHL3	Q13643	PIERCE1	Homo sapiens	Q5BN46	Y2H Array	25416956
Intra	FHL3	Q13643	EPHA10	Homo sapiens	Q5JZY3-3	Validated Y2H	25416956
Intra	FHL3	Q13643	EFCAB12	Homo sapiens	Q6NXP0	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	ASCL4	Homo sapiens	Q6XD76	Validated Y2H	32296183
Intra	FHL3	Q13643	UBE2Q1	Homo sapiens	Q7Z7E8-2	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	SLC44A3	Homo sapiens	Q8N4M1	Y2H Array	25416956
Intra	FHL3	Q13643	SLC44A3	Homo sapiens	Q8N4M1	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	SLAIN1	Homo sapiens	Q8ND83	Validated Y2H	25416956
Intra	FHL3	Q13643	SLAIN1	Homo sapiens	Q8ND83	Validated Y2H	32296183
Intra	FHL3	Q13643	CNNM3	Homo sapiens	Q8NE01-3	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	CNNM3	Homo sapiens	Q8NE01-3	Validated Y2H	25416956
Intra	FHL3	Q13643	SLC25A46	Homo sapiens	Q96AG3	Validated Y2H	32296183
Intra	FHL3	Q13643	C16orf35	Homo sapiens	Q9BTE2	Validated Y2H	25416956
Intra	FHL3	Q13643	C16orf35	Homo sapiens	Q9BTE2	Y2H Array	25416956
Intra	FHL3	Q13643	MRM3	Homo sapiens	Q9HC36	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	MRM3	Homo sapiens	Q9HC36	Validated Y2H	25416956
Intra	FHL3	Q13643	MRM3	Homo sapiens	Q9HC36	Validated Y2H	32296183
Intra	FHL3	Q13643	MRM3	Homo sapiens	Q9HC36	Y2H Array	25416956
Intra	FHL3	Q13643	ZNF512B	Homo sapiens	Q96KM6	Anti Tag CoIP	33961781
Intra	FHL3	Q13643	ZNF512B	Homo sapiens	Q96KM6	Y2H Array	31515488
Intra	FHL3	Q13643	ZNF512B	Homo sapiens	Q96KM6	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	ZNF512B	Homo sapiens	Q96KM6	Anti Tag CoIP	28514442
Intra	FHL3	Q13643	ZNF512B	Homo sapiens	Q96KM6	Validated Y2H	32296183
Intra	FHL3	Q13643	ZNF512B	Homo sapiens	Q96KM6	Y2H Array	25416956
Intra	FHL3	Q13643	MSRB3	Homo sapiens	Q8IXL7-2	Validated Y2H	32296183
Intra	FHL3	Q13643	KPRP	Homo sapiens	Q5T749	Validated Y2H	27107012
Intra	FHL3	Q13643	KPRP	Homo sapiens	Q5T749	BFG-2H	27107012
Intra	FHL3	Q13643	PKP2	Homo sapiens	Q99959-2	Validated Y2H	32296183
Intra	FHL3	Q13643	KIDINS220	Homo sapiens	Q9ULH0-2	Validated Y2H	32296183
Intra	FHL3	Q13643	ANKHD1	Homo sapiens	A0A0A0MQZ8	Validated Y2H	27107012
Intra	FHL3	Q13643	ANKHD1	Homo sapiens	A0A0A0MQZ8	BFG-2H	27107012
Intra	FHL3	Q13643	PLEKHG4B	Homo sapiens	Q96PX9	BFG-2H	27107012
Intra	FHL3	Q13643	TLE5	Homo sapiens	Q08117-2	BFG-2H	27107012
Intra	FHL3	Q13643	VWC2L	Homo sapiens	B2RUY7	Validated Y2H	27107012
Intra	FHL3	Q13643	FOXN4	Homo sapiens	Q96NZ1	BFG-2H	27107012
Intra	FHL3	Q13643	HAPLN2	Homo sapiens	Q9GZV7	Validated Y2H	32296183
Intra	FHL3	Q13643	GUCD1	Homo sapiens	Q96NT3-2	Validated Y2H	32296183
Intra	FHL3	Q13643	TTLL10	Homo sapiens	Q6ZVT0-3	Validated Y2H	32296183
Intra	FHL3	Q13643	DLGAP4	Homo sapiens	Q9Y2H0-1	Validated Y2H	32296183
Intra	FHL3	Q13643	SAXO4	Homo sapiens	Q7Z5V6-2	Validated Y2H	32296183
Intra	FHL3	Q13643	HIPK1	Homo sapiens	Q86Z02-4	Validated Y2H	32296183
Intra	FHL3	Q13643	WDR25	Homo sapiens	Q64LD2-2	Validated Y2H	32296183
Intra	FHL3	Q13643	BARX2	Homo sapiens	Q9UMQ3	Validated Y2H	32296183
Intra	FHL3	Q13643	CASS4	Homo sapiens	Q9NQ75-2	Validated Y2H	32296183
Intra	FHL3	Q13643	PIERCE1	Homo sapiens	Q5BN46-2	Validated Y2H	32296183
Intra	FHL3	Q13643	NDUFAB1	Homo sapiens	O14561	Y2H Prey Pooling	32296183
Intra	FHL3	Q13643	KIRREL2	Homo sapiens	Q6UWL6-5	Validated Y2H	32296183
Intra	FHL3	Q13643	RASL12	Homo sapiens	Q9NYN1	Validated Y2H	32296183
Intra	FHL3	Q13643	CRIP3	Homo sapiens	Q6Q6R5-3	Validated Y2H	32296183
Intra	FHL3	Q13643	TYK2	Homo sapiens	P29597	Y2H Array	25416956
Intra	FHL3	Q13643	TYK2	Homo sapiens	P29597	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	PRR5L	Homo sapiens	Q6MZQ0	Validated Y2H	32296183
Intra	FHL3	Q13643	FAM110A	Homo sapiens	Q9BQ89	Validated Y2H	32296183
Intra	FHL3	Q13643	AMBP	Homo sapiens	P02760	Y2H Array	25416956
Intra	FHL3	Q13643	LNX2	Homo sapiens	Q8N448	BFG-2H	27107012
Intra	FHL3	Q13643	TMX3	Homo sapiens	Q96JJ7	Y2H Array	25416956
Intra	FHL3	Q13643	TUBA3E	Homo sapiens	Q6PEY2	Validated Y2H	32296183
Intra	FHL3	Q13643	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	FHL3	Q13643	PATL1	Homo sapiens	Q86TB9	Validated Y2H	25416956
Intra	FHL3	Q13643	PATL1	Homo sapiens	Q86TB9	Validated Y2H	32296183
Intra	FHL3	Q13643	SBF2	Homo sapiens	Q86WG5	Validated Y2H	32296183
Intra	FHL3	Q13643	QRICH1	Homo sapiens	Q2TAL8	Y2H Array	25416956
Intra	FHL3	Q13643	QRICH1	Homo sapiens	Q2TAL8	Anti Tag CoIP	33961781
Intra	FHL3	Q13643	QRICH1	Homo sapiens	Q2TAL8	Validated Y2H	32296183
Intra	FHL3	Q13643	QRICH1	Homo sapiens	Q2TAL8	Validated Y2H	25416956
Intra	FHL3	Q13643	HYAL2	Homo sapiens	Q12891	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	HYAL2	Homo sapiens	Q12891	Validated Y2H	25416956
Intra	FHL3	Q13643	GATA2	Homo sapiens	P23769	Validated Y2H	25416956
Intra	FHL3	Q13643	GATA2	Homo sapiens	P23769	Y2H Array	31515488
Intra	FHL3	Q13643	FAM222B	Homo sapiens	Q8WU58	Validated Y2H	32296183
Intra	FHL3	Q13643	A1CF	Homo sapiens	Q9NQ94	Validated Y2H	25416956
Intra	FHL3	Q13643	A1CF	Homo sapiens	Q9NQ94	Y2H Array	25416956
Intra	FHL3	Q13643	MRRF	Homo sapiens	Q96E11	Validated Y2H	32296183
Intra	FHL3	Q13643	MYPOP	Homo sapiens	Q86VE0	Validated Y2H	32296183
Intra	FHL3	Q13643	CSF1	Homo sapiens	P09603	Validated Y2H	25416956
Intra	FHL3	Q13643	LATS2	Homo sapiens	Q9NRM7	Validated Y2H	27107012
Intra	FHL3	Q13643	LATS2	Homo sapiens	Q9NRM7	BFG-2H	27107012
Intra	FHL3	Q13643	ZFP36	Homo sapiens	P26651	BFG-2H	27107012
Intra	FHL3	Q13643	ZFP36	Homo sapiens	P26651	Validated Y2H	27107012
Intra	FHL3	Q13643	FOSL2	Homo sapiens	P15408	Validated Y2H	25416956
Intra	FHL3	Q13643	FOSL2	Homo sapiens	P15408	Y2H Array	25416956
Intra	FHL3	Q13643	ZCCHC14	Homo sapiens	Q8WYQ9	Validated Y2H	32296183
Intra	FHL3	Q13643	FADS6	Homo sapiens	Q8N9I5	Validated Y2H	32296183
Intra	FHL3	Q13643	SHE	Homo sapiens	Q5VZ18	Validated Y2H	32296183
Intra	FHL3	Q13643	SAXO1	Homo sapiens	Q8IYX7	Validated Y2H	32296183
Intra	FHL3	Q13643	SAXO1	Homo sapiens	Q8IYX7	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	SAXO1	Homo sapiens	Q8IYX7	Y2H Array	25416956
Intra	FHL3	Q13643	SAXO1	Homo sapiens	Q8IYX7	Y2H Array	31515488
Intra	FHL3	Q13643	MRPL27	Homo sapiens	Q9P0M9	Validated Y2H	32296183
Intra	FHL3	Q13643	MRPL27	Homo sapiens	Q9P0M9	Y2H Array	25416956
Intra	FHL3	Q13643	MYOZ3	Homo sapiens	Q8TDC0	Validated Y2H	32296183
Intra	FHL3	Q13643	SNRPG	Homo sapiens	P62308	Validated Y2H	25416956
Intra	FHL3	Q13643	SNRPG	Homo sapiens	P62308	Y2H Array	25416956
Intra	FHL3	Q13643	EPM2AIP1	Homo sapiens	Q7L775	Y2H Array	25416956
Intra	FHL3	Q13643	EPM2AIP1	Homo sapiens	Q7L775	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
Intra	FHL3	Q13643	FAM90A1	Homo sapiens	Q86YD7	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	25416956
Intra	FHL3	Q13643	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	FHL3	Q13643	FAM90A1	Homo sapiens	Q86YD7	Y2H Array	25416956
Intra	FHL3	Q13643	HIPK1	Homo sapiens	Q86Z02	Anti Tag CoIP	33961781
Intra	FHL3	Q13643	HIPK1	Homo sapiens	Q86Z02	Anti Tag CoIP	28514442
Intra	FHL3	Q13643	HIPK1	Homo sapiens	Q86Z02	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	TMEM108	Homo sapiens	Q6UXF1	Validated Y2H	32296183
Intra	FHL3	Q13643	CBX8	Homo sapiens	Q9HC52	Validated Y2H	32296183
Intra	FHL3	Q13643	LMO2	Homo sapiens	P25791	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	25416956
Intra	FHL3	Q13643	ZNF417	Homo sapiens	Q8TAU3	Y2H Array	25416956
Intra	FHL3	Q13643	CNNM3	Homo sapiens	Q8NE01	Validated Y2H	32296183
Intra	FHL3	Q13643	CNNM3	Homo sapiens	Q8NE01	Y2H	21516116
Intra	FHL3	Q13643	THAP7	Homo sapiens	Q9BT49	Y2H Prey Pooling	32296183
Intra	FHL3	Q13643	THAP7	Homo sapiens	Q9BT49	Validated Y2H	32296183
Intra	FHL3	Q13643	CTBP2	Homo sapiens	P56545	BFG-2H	27107012
Intra	FHL3	Q13643	TYMSOS	Homo sapiens	Q8TAI1	Validated Y2H	25416956
Intra	FHL3	Q13643	RFX3	Homo sapiens	P48380	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	RFX3	Homo sapiens	P48380	Y2H Array	25416956
Intra	FHL3	Q13643	FBXL18	Homo sapiens	Q96D16	Y2H Array	25416956
Intra	FHL3	Q13643	FBXL18	Homo sapiens	Q96D16	Validated Y2H	25416956
Intra	FHL3	Q13643	PHF21A	Homo sapiens	Q96BD5	Validated Y2H	32296183
Intra	FHL3	Q13643	PHF21A	Homo sapiens	Q96BD5	Y2H Array	31515488
Intra	FHL3	Q13643	AIMP2	Homo sapiens	Q13155	Validated Y2H	27107012
Intra	FHL3	Q13643	AIMP2	Homo sapiens	Q13155	BFG-2H	27107012
Intra	FHL3	Q13643	AIMP2	Homo sapiens	Q13155	Y2H Pooling	16189514
Intra	FHL3	Q13643	RHEBL1	Homo sapiens	Q8TAI7	Validated Y2H	25416956
Intra	FHL3	Q13643	IKZF3	Homo sapiens	Q9UKT9	BFG-2H	27107012
Intra	FHL3	Q13643	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	27107012
Intra	FHL3	Q13643	RSPH14	Homo sapiens	Q9UHP6	Validated Y2H	32296183
Intra	FHL3	Q13643	KLF12	Homo sapiens	Q9Y4X4	Validated Y2H	32296183
Intra	FHL3	Q13643	SPMAP2	Homo sapiens	Q9P2T0	Y2H Array	31515488
Intra	FHL3	Q13643	SPMAP2	Homo sapiens	Q9P2T0	Validated Y2H	32296183
Intra	FHL3	Q13643	SAP30BP	Homo sapiens	Q9UHR5	Validated Y2H	32296183
Intra	FHL3	Q13643	SAP30BP	Homo sapiens	Q9UHR5	Y2H Array	25416956
Intra	FHL3	Q13643	GARIN6	Homo sapiens	Q8NEG0	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	E2F8	Homo sapiens	A0AVK6	Validated Y2H	25416956
Intra	FHL3	Q13643	E2F8	Homo sapiens	A0AVK6	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	ADAM15	Homo sapiens	Q13444	Validated Y2H	25416956
Intra	FHL3	Q13643	PTPN6	Homo sapiens	P29350	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	PTPN6	Homo sapiens	P29350	Validated Y2H	25416956
Intra	FHL3	Q13643	TTLL10	Homo sapiens	Q6ZVT0	Validated Y2H	25416956
Intra	FHL3	Q13643	TTLL10	Homo sapiens	Q6ZVT0	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	KTI12	Homo sapiens	Q96EK9	Validated Y2H	25416956
Intra	FHL3	Q13643	KTI12	Homo sapiens	Q96EK9	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	RAD21	Homo sapiens	O60216	Y2H Array	31515488
Intra	FHL3	Q13643	RAD21	Homo sapiens	O60216	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	RAD21	Homo sapiens	O60216	Validated Y2H	25416956
Intra	FHL3	Q13643	KLF3	Homo sapiens	P57682	Y2H Prey Pooling	25416956
Intra	FHL3	Q13643	KLF3	Homo sapiens	P57682	Y2H Array	25416956
Intra	FHL3	Q13643	KLF3	Homo sapiens	P57682	Validated Y2H	27107012
Intra	FHL3	Q13643	KLF3	Homo sapiens	P57682	BFG-2H	27107012
Intra	FHL3	Q13643	KLF3	Homo sapiens	P57682	Validated Y2H	25416956
Intra	FHL3	Q13643	IHO1	Homo sapiens	Q8IYA8	BFG-2H	27107012
Intra	FHL3	Q13643	IHO1	Homo sapiens	Q8IYA8	Validated Y2H	27107012
Intra	FHL3	Q13643	TBC1D22B	Homo sapiens	Q9NU19	Validated Y2H	32296183
Intra	FHL3	Q13643	MYBPHL	Homo sapiens	A2RUH7	Y2H Array	25416956
Intra	FHL3	Q13643	GATA1	Homo sapiens	P15976-2	BFG-2H	27107012
Intra	FHL3	Q13643	GATA1	Homo sapiens	P15976-2	Validated Y2H	27107012
Intra	FHL3	Q13643	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	32296183
Intra	FHL3	Q13643	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Holoprosencephaly 9	Pituitary Anomalies With Holoprosencephaly-Like Features HPE9 Holoprosencephaly With Microphthalmia And First Branchial Arch Anomalies Holoprosencephaly-9 Holoprosencephaly, Type 9
Glycogen Storage Disease Vii	Glycogen Storage Disease Type Vii Muscle Phosphofructokinase Deficiency Tarui Disease GSD7 Pfkm Deficiency Gsd Vii Glycogen Storage Disease, Type Vii Glycogen Storage Disease Type 7 Phosphofructokinase Deficiency Glycogenosis Type Vii Phosphofructokinase Myopathy Glycogenosis 7 Glycogen Storage Disease Due To Muscle Phosphofructokinase Deficiency Gsd Due To Muscle Phosphofructokinase Deficiency Gsd Type 7 Gsd Type Vii Glycogenosis Due To Muscle Phosphofructokinase Deficiency Glycogenosis Type 7 Glycogen Storage Disease 7 Gsd-Vii Storage Disease, Glycogen, Type Vii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N6896	Isoviolanthin	Inhibitor	99.87%	Unkown
HY-RS04936	FHL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15467	UNC13D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20733	Fhl3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27245	Fhl3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FHL3	MGD	MGI:1341092
Felis catus	FHL3	VGNC	VGNC:62266
Macaca mulatta	FHL3	VGNC	VGNC:72662
Bos taurus	FHL3	VGNC	VGNC:29001
Canis familiaris	FHL3	VGNC	VGNC:40873
Rattus norvegicus	FHL3	RGD	RGD:1307180
Others	FHL3	NCBI