PLEKHG4B - pleckstrin homology and RhoGEF domain containing G4B Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 153478

About PLEKHG4B

This gene has 4 transcripts (splice variants), 144 orthologues and 22 paralogues. Biased expression in thyroid (RPKM 1.2), testis (RPKM 0.6) and 8 other tissues.

Summary

This gene encodes a large protein that contains a pleckstrin homology domain and may function as a guanine nucleotide exchange factor. [provided by RefSeq, May 2017]

PLEKHG4B Products (1)

mRNA Protein Name
NM_052909.5 NP_443141.4 pleckstrin homology domain-containing family G member 4B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
32203420 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
27107012 GOA
Biological Process GO Annotation Evidence References Source
involved in cell-cell adhesion IDA
IDA: Inferred from direct assay
33310911 GOA
Cellular Component GO Annotation Evidence References Source
located in basal plasma membrane IDA
IDA: Inferred from direct assay
38088892 GOA
located in cell-cell junction IDA
IDA: Inferred from direct assay
33310911 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
33310911 GOA
located in nucleus IDA
IDA: Inferred from direct assay
33310911 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLEKHG4B Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (809 - 954)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1271 a.a.
Protein Preferred Names Protein Names

pleckstrin homology domain-containing family G member 4B

  • PH domain-containing family G member 4B

PLEKHG4B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLEKHG4B Q96PX9 ARHGEF11 Homo sapiens O15085-1
Anti Tag CoIP
32203420
Intra
PLEKHG4B Q96PX9 FHL3 Homo sapiens Q13643
Validated Y2H
27107012
Intra
PLEKHG4B Q96PX9 ARHGEF12 Homo sapiens Q9NZN5-1
Anti Tag CoIP
32203420
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cri-Du-Chat Syndrome

  • 5p Deletion Syndrome

  • 5p Partial Monosomy Syndrome

  • Monosomy 5p

  • Cat Cry Syndrome

  • Chromosome 5p Deletion Syndrome

  • Cri Du Chat Syndrome

  • 5p- Syndrome

  • 5p Minus Syndrome

  • Chromosome 5p- Syndrome

  • Chromosome 5 Short Arm Deletion Syndrome

  • Chromosome 5p Deletion

  • Deletion 5p

  • Cri Du Chat

  • 5p Partial Deletion Syndrome

  • Partial Deletion Of Short Arm Of Chromosome 5 Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10692 PLEKHG4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown