A1CF - APOBEC1 complementation factor Gene

Homo sapiens

Also known as ACF; ASP; ACF64; ACF65; APOBEC1CF

Gene ID: 29974 | Gene type: protein coding

About A1CF

Cytogenetic location: 10q11.23 Genomic coordinates (GRCh38): 10:50,799,409-50,885,627 (from NCBI)

This gene has 10 transcripts (splice variants), 202 orthologues, 36 paralogues and is associated with 64 phenotypes. Biased expression in liver (RPKM 31.2), small intestine (RPKM 8.6) and 4 other tissues.

Summary

Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component Enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

A1CF Products(8)

mRNA	Protein	Name
NM_001198818.2	NP_001185747.1	APOBEC1 complementation factor isoform 1
NM_001198819.2	NP_001185748.1	APOBEC1 complementation factor isoform 4
NM_001198820.2	NP_001185749.1	APOBEC1 complementation factor isoform 3
NM_001370130.1	NP_001357059.1	APOBEC1 complementation factor isoform 1
NM_001370131.1	NP_001357060.1	APOBEC1 complementation factor isoform 2
NM_014576.4	NP_055391.2	APOBEC1 complementation factor isoform 1
NM_138932.3	NP_620310.1	APOBEC1 complementation factor isoform 2
NM_138933.3	NP_620311.1	APOBEC1 complementation factor isoform 3

A1CF Protein Structure

RRM_1

DND1_DSRM

0
100
200
300
400
500
594 a.a.

Protein Preferred Names

Protein Names

APOBEC1 complementation factor

APOBEC-1 stimulating protein

Related Diseases

Diseases

Alias

Phosphoribosylpyrophosphate Synthetase Superactivity

PRPS1 SUPERACTIVITY	Prpp Synthetase Superactivity
Gout, Prps-Related	Prpp Synthetase Deficiency
Prpp Synthetase Overactivity	Prs Overactivity
Prs Superactivity	Mild Phosphoribosylpyrophosphate Synthetase Superactivity
Mild Prpp Synthetase Superactivity	Mild Prps1 Superactivity
Severe Phosphoribosylpyrophosphate Synthetase Superactivity	Severe Prpp Synthetase Superactivity
Severe Prps1 Superactivity	Prps-Related Gout
Superactivity, Phosphoribosylpyrophosphate Synthetase

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00009	A1CF Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	A1CF	VGNC	VGNC:59445
Rattus norvegicus	A1CF	RGD	RGD:619834
Canis familiaris	A1CF	VGNC	VGNC:37399
Bos taurus	A1CF	VGNC	VGNC:25434
Mus musculus	A1CF	MGD	MGI:1917115
Macaca mulatta	A1CF	VGNC	VGNC:69523