A1CF - APOBEC1 complementation factor Gene

Also Known as ACF; ASP; ACF64; ACF65; APOBEC1CF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29974

About A1CF

Cytogenetic location: 10q11.23 Genomic coordinates (GRCh38): 10:50,799,409-50,885,627 (from NCBI)

This gene has 10 transcripts (splice variants), 202 orthologues, 36 paralogues and is associated with 64 phenotypes. Biased expression in liver (RPKM 31.2), small intestine (RPKM 8.6) and 4 other tissues.

Summary

Mammalian Apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in Other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

A1CF Products (8)

mRNA Protein Name
NM_001198818.2 NP_001185747.1 APOBEC1 complementation factor isoform 1
NM_001198819.2 NP_001185748.1 APOBEC1 complementation factor isoform 4
NM_001198820.2 NP_001185749.1 APOBEC1 complementation factor isoform 3
NM_001370130.1 NP_001357059.1 APOBEC1 complementation factor isoform 1
NM_001370131.1 NP_001357060.1 APOBEC1 complementation factor isoform 2
NM_014576.4 NP_055391.2 APOBEC1 complementation factor isoform 1
NM_138932.3 NP_620310.1 APOBEC1 complementation factor isoform 2
NM_138933.3 NP_620311.1 APOBEC1 complementation factor isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
11871661 GOA
enables enzyme-substrate adaptor activity IDA
IDA: Inferred from direct assay
11871661 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10669759 GOA
enables single-stranded RNA binding IDA
IDA: Inferred from direct assay
11871661 GOA
Biological Process GO Annotation Evidence References Source
involved in cytidine to uridine editing IDA
IDA: Inferred from direct assay
24916387 GOA
involved in mRNA modification IDA
IDA: Inferred from direct assay
11134005 GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
IDA: Inferred from direct assay
12881431 GOA
involved in protein stabilization IDA
IDA: Inferred from direct assay
12881431 GOA
Cellular Component GO Annotation Evidence References Source
part of apolipoprotein B mRNA editing enzyme complex IDA
IDA: Inferred from direct assay
10781591 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
12881431 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12881431 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

A1CF Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (58 - 124)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (138 - 199)

(233 - 297)

DND1_DSRM

DND1_DSRM: double strand RNA binding domain from DEAD END PROTEIN 1 (447 - 523)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 594 a.a.
Protein Preferred Names Protein Names

APOBEC1 complementation factor

  • APOBEC-1 stimulating protein

A1CF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
A1CF Q9NQ94 RIMBP3 Homo sapiens Q9UFD9
Y2H Array
32296183
Intra
A1CF Q9NQ94 RIMBP3 Homo sapiens Q9UFD9
Y2H Prey Pooling
32296183
Intra
A1CF Q9NQ94 RIMBP3 Homo sapiens Q9UFD9
Validated Y2H
32296183
Intra
A1CF Q9NQ94 SPMIP6 Homo sapiens Q8NCR6
Y2H Array
32296183
Intra
A1CF Q9NQ94 SPMIP6 Homo sapiens Q8NCR6
Y2H Prey Pooling
32296183
Intra
A1CF Q9NQ94 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
A1CF Q9NQ94 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
A1CF Q9NQ94 DOK3 Homo sapiens Q7L591-3
Y2H Prey Pooling
32296183
Intra
A1CF Q9NQ94 DOK3 Homo sapiens Q7L591-3
Y2H Array
32296183
Intra
A1CF Q9NQ94 ACTMAP Homo sapiens Q5BKX5-3
Y2H Prey Pooling
32296183
Intra
A1CF Q9NQ94 ACTMAP Homo sapiens Q5BKX5-3
Y2H Array
32296183
Intra
A1CF Q9NQ94 EIF4G1 Homo sapiens Q04637-9
Y2H Array
32296183
Intra
A1CF Q9NQ94 EIF4G1 Homo sapiens Q04637-9
Y2H Prey Pooling
32296183
Intra
A1CF Q9NQ94 POGZ Homo sapiens Q7Z3K3
Y2H Array
32296183
Intra
A1CF Q9NQ94 POGZ Homo sapiens Q7Z3K3
Y2H Prey Pooling
32296183
Intra
A1CF Q9NQ94 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra
A1CF Q9NQ94 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra
A1CF Q9NQ94 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
A1CF Q9NQ94 TRAF1 Homo sapiens Q13077
Validated Y2H
25416956
Intra
A1CF Q9NQ94 TRAF1 Homo sapiens Q13077
Y2H Array
25416956
Intra
A1CF Q9NQ94 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Intra
A1CF Q9NQ94 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra
A1CF Q9NQ94 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
25416956
Intra
A1CF Q9NQ94 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
A1CF Q9NQ94 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
A1CF Q9NQ94 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra
A1CF Q9NQ94 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra
A1CF Q9NQ94 FHL2 Homo sapiens Q14192
Y2H Prey Pooling
32296183
Intra
A1CF Q9NQ94 FHL2 Homo sapiens Q14192
Y2H Array
32296183
Intra
A1CF Q9NQ94 HSPB2 Homo sapiens Q16082
Y2H Prey Pooling
32296183
Intra
A1CF Q9NQ94 HSPB2 Homo sapiens Q16082
Y2H Array
32296183
Intra
A1CF Q9NQ94 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
25416956
Intra
A1CF Q9NQ94 METTL27 Homo sapiens Q8N6F8
Y2H Prey Pooling
32296183
Intra
A1CF Q9NQ94 METTL27 Homo sapiens Q8N6F8
Y2H Array
32296183
Intra
A1CF Q9NQ94 KLHDC7B Homo sapiens Q96G42
Y2H Prey Pooling
32296183
Intra
A1CF Q9NQ94 KLHDC7B Homo sapiens Q96G42
Y2H Array
32296183
Intra
A1CF Q9NQ94 ECM1 Homo sapiens Q16610
Y2H Array
32296183
Intra
A1CF Q9NQ94 ECM1 Homo sapiens Q16610
Y2H Prey Pooling
32296183
Intra
A1CF Q9NQ94 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
A1CF Q9NQ94 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
A1CF Q9NQ94 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Intra
A1CF Q9NQ94 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Phosphoribosylpyrophosphate Synthetase Superactivity

  • PRPS1 SUPERACTIVITY

  • Prpp Synthetase Superactivity

  • Gout, Prps-Related

  • Prpp Synthetase Deficiency

  • Prpp Synthetase Overactivity

  • Prs Overactivity

  • Prs Superactivity

  • Mild Phosphoribosylpyrophosphate Synthetase Superactivity

  • Mild Prpp Synthetase Superactivity

  • Mild Prps1 Superactivity

  • Severe Phosphoribosylpyrophosphate Synthetase Superactivity

  • Severe Prpp Synthetase Superactivity

  • Severe Prps1 Superactivity

  • Prps-Related Gout

  • Superactivity, Phosphoribosylpyrophosphate Synthetase
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00009 A1CF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22090 A1cf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus A1CF VGNC VGNC:59445
Rattus norvegicus A1CF RGD RGD:619834
Canis familiaris A1CF VGNC VGNC:37399
Bos taurus A1CF VGNC VGNC:25434
Mus musculus A1CF MGD MGI:1917115
Macaca mulatta A1CF VGNC VGNC:69523
Others A1CF NCBI