E2F8 - E2F transcription factor 8 Gene

Also Known as E2F-8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79733

About E2F8

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:19,224,063-19,241,655 (from NCBI)

This gene has 5 transcripts (splice variants), 195 orthologues and 7 paralogues. Broad expression in bone marrow (RPKM 4.6), lymph node (RPKM 3.5) and 14 other tissues.

Summary

This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]

E2F8 Products (3)

mRNA Protein Name
NM_001256371.2 NP_001243300.1 transcription factor E2F8
NM_001256372.1 NP_001243301.1 transcription factor E2F8
NM_024680.4 NP_078956.2 transcription factor E2F8

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
22903062 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
16179649 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16179649 GOA
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
22903062 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18202719 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16179649 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22903062 GOA
involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
22903062 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

E2F8 Protein Structure

E2F_TDP

E2F_TDP: E2F/DP family winged-helix DNA-binding domain (113 - 182)

E2F_TDP

E2F_TDP: E2F/DP family winged-helix DNA-binding domain (261 - 347)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 867 a.a.
Protein Preferred Names Protein Names

transcription factor E2F8

  • E2F family member 8

E2F8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
E2F8 A0AVK6 E2F7 Homo sapiens Q96AV8
Anti Bait CoIP
18202719
Intra
E2F8 A0AVK6 E2F7 Homo sapiens Q96AV8
Anti Tag CoIP
18202719
Intra
E2F8 A0AVK6 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
E2F8 A0AVK6 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
E2F8 A0AVK6 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
E2F8 A0AVK6 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra
E2F8 A0AVK6 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra
E2F8 A0AVK6 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra
E2F8 A0AVK6 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
E2F8 A0AVK6 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
E2F8 A0AVK6 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
E2F8 A0AVK6 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
E2F8 A0AVK6 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
E2F8 A0AVK6 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
E2F8 A0AVK6 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
E2F8 A0AVK6 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
E2F8 A0AVK6 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
E2F8 A0AVK6 STUB1 Homo sapiens Q9UNE7
Y2H Prey Pooling
32296183
Intra
E2F8 A0AVK6 STUB1 Homo sapiens Q9UNE7
Validated Y2H
32296183
Intra
E2F8 A0AVK6 STUB1 Homo sapiens Q9UNE7
Y2H Array
32296183
Intra
E2F8 A0AVK6 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
E2F8 A0AVK6 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
E2F8 A0AVK6 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
E2F8 A0AVK6 TFCP2 Homo sapiens Q12800
Validated Y2H
25416956
Intra
E2F8 A0AVK6 TFCP2 Homo sapiens Q12800
Y2H Array
25416956
Intra
E2F8 A0AVK6 TFCP2 Homo sapiens Q12800
Y2H Prey Pooling
25416956
Intra
E2F8 A0AVK6 FHL3 Homo sapiens Q13643
Y2H Array
25416956
Intra
E2F8 A0AVK6 SNCA Homo sapiens P37840
Validated Y2H
32814053
Intra
E2F8 A0AVK6 SNCA Homo sapiens P37840
Y2H Pooling
32814053
Intra
E2F8 A0AVK6 SNCA Homo sapiens P37840
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Bilateral Retinoblastoma
Retinal Cancer

  • Malignant Neoplasm Of Retina

  • Retinal Neoplasms

  • Malignant Retinal Neoplasm

  • Malignant Tumor Of Retina

  • Neoplasm Of Retina

  • Retinal Tumor

  • Retinal Neoplasm

  • Cancer Of The Retina

  • Malignant Retinal Tumour

  • Malignant Tumour Of Retina

  • Primary Malignant Neoplasm Of Retina
Soft Palate Cancer

  • Malignant Tumor Of Soft Palate

  • Malignant Tumor Of The Soft Palate

  • Palate Cancer Soft Palate
Familial Retinoblastoma

  • Hereditary Retinoblastoma

  • Retinoblastoma
Ocular Cancer

  • Eye Neoplasm

  • Eye Carcinoma

  • Eye Cancer

  • Eye Neoplasms

  • Malignant Eye Neoplasm

  • Neoplasm Of Eye

  • Neoplasm Of Eye Proper

  • Ocular Tumor

  • Carcinoma Of Eye

  • Ocular Carcinoma

  • Malignant Tumor Of Eye
Retinal Disease

  • Retinal Diseases

  • Retinal Disorder

  • Retinal Disorders
Eye Disease

  • Eye Diseases

  • Abnormality Of The Eye

  • Toxoplasma Oculopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04117 E2F8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22149 E2f8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta E2F8 VGNC VGNC:71900
Canis familiaris E2F8 VGNC VGNC:40170
Felis catus E2F8 VGNC VGNC:61699
Rattus norvegicus E2F8 RGD RGD:1308091
Bos taurus E2F8 VGNC VGNC:28292
Mus musculus E2F8 MGD MGI:1922038
Others E2F8 NCBI