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RASL12 - RAS like family 12 Gene

Also Known as RIS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51285

About RASL12

This gene has 3 transcripts (splice variants), 183 orthologues and 35 paralogues. Broad expression in prostate (RPKM 19.4), endometrium (RPKM 17.1) and 21 other tissues.

Summary

Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in signal transduction. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RASL12 Products (3)

mRNA	Protein	Name
NM_001307930.2	NP_001294859.1	ras-like protein family member 12 isoform 2
NM_001379429.1	NP_001366358.1	ras-like protein family member 12 isoform 3
NM_016563.4	NP_057647.1	ras-like protein family member 12 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASL12 Protein Structure

Ras

0
100
200
266 a.a.

Protein Preferred Names	Protein Names
ras-like protein family member 12	Ras family member Ris

RASL12 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RASL12	Q9NYN1	FHL2	Homo sapiens	Q14192	Anti Tag CoIP	33961781
Intra	RASL12	Q9NYN1	FHL2	Homo sapiens	Q14192	Anti Tag CoIP	28514442
Intra	RASL12	Q9NYN1	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	RASL12	Q9NYN1	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bile Acid Malabsorption, Primary, 2	PBAM2
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Cholestasis	Obstruction Of Bile Duct Bile Duct Obstruction Bile Occlusion Extrahepatic Biliary Obstruction Extrahepatic Bile Duct Obstruction Bile Stasis Biliary Stasis Obstructive Hyperbilirubinemia Obstructed Jaundice Bile Duct Obstructed Bile Ductal Obstruction Biliary Duct Obstruction Obstructed Bile Ductal Obstructed Biliary Duct Obstructed Biliary Ductal Jaundice Regurgitation Obstructive Jaundice Cholestatic Jaundice Cholestatic Jaundice Syndrome
Acrofacial Dysostosis 1, Nager Type	Nager Syndrome Nager Acrofacial Dysostosis AFD1 Preaxial Acrofacial Dysostosis Mandibulofacial Dysostosis, Treacher Collins Type, With Limb Anomalies Afd, Nager Type Nager Acrofacial Dysostosis Syndrome Nafd Acrofacial Dysostosis, Nager Type Afd Preaxial Manibulofacial Dysostosis Split Hand Deformity-Mandibulofacial Dysostosis Preaxial Mandibulofacial Dysostosis Mandibulofacial Dysostosis With Preaxial Limb Anomalies Preaxial Acrodysostosis Afd Nager Type Mandibulofacial Dysostosis Treacher Collins Type With Limb Anomalies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11700	RASL12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RASL12	VGNC	VGNC:64506
Rattus norvegicus	RASL12	RGD	RGD:1306268
Canis familiaris	RASL12	VGNC	VGNC:58328
Mus musculus	RASL12	MGD	MGI:1918034
Macaca mulatta	RASL12	VGNC	VGNC:76573
Bos taurus	RASL12	VGNC	VGNC:33756
Others	RASL12	NCBI