VWC2L - von Willebrand factor C domain containing 2 like Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 402117

Summary

Predicted to be involved in negative regulation of BMP signaling pathway. Predicted to act upstream of or within positive regulation of neuron differentiation. Predicted to be located in extracellular region and synapse. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in obsolete extracellular space. [provided by Alliance of Genome Resources, Jun 2026]
Restricted expression toward brain (RPKM 1.2).

VWC2L Products (2)

mRNA Protein Name
NM_001080500.4 NP_001073969.1 von Willebrand factor C domain-containing protein 2-like isoform 1 precursor
NM_001345929.2 NP_001332858.1 von Willebrand factor C domain-containing protein 2-like isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
27107012 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VWC2L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VWC2L B2RUY7 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
VWC2L B2RUY7 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
VWC2L B2RUY7 KRTAP11-1 Homo sapiens Q8IUC1
Validated Y2H
32296183
Intra
VWC2L B2RUY7 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
Intra
VWC2L B2RUY7 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 LCE5A Homo sapiens Q5TCM9
Validated Y2H
32296183
Intra
VWC2L B2RUY7 LCE5A Homo sapiens Q5TCM9
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 LCE5A Homo sapiens Q5TCM9
Y2H Array
32296183
Intra
VWC2L B2RUY7 LCE1A Homo sapiens Q5T7P2
Validated Y2H
32296183
Intra
VWC2L B2RUY7 LCE1A Homo sapiens Q5T7P2
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 LCE1A Homo sapiens Q5T7P2
Y2H Array
32296183
Intra
VWC2L B2RUY7 CXCL5 Homo sapiens P42830
Y2H Array
32296183
Intra
VWC2L B2RUY7 CXCL5 Homo sapiens P42830
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 CXCL5 Homo sapiens P42830
Validated Y2H
32296183
Intra
VWC2L B2RUY7 KRTAP19-2 Homo sapiens Q3LHN2
Validated Y2H
32296183
Intra
VWC2L B2RUY7 KRTAP19-2 Homo sapiens Q3LHN2
Y2H Array
32296183
Intra
VWC2L B2RUY7 KRTAP19-2 Homo sapiens Q3LHN2
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 LCE1C Homo sapiens Q5T751
Validated Y2H
32296183
Intra
VWC2L B2RUY7 LCE1C Homo sapiens Q5T751
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 LCE1C Homo sapiens Q5T751
Y2H Array
32296183
Intra
VWC2L B2RUY7 RIPK4 Homo sapiens P57078-2
Validated Y2H
32296183
Intra
VWC2L B2RUY7 RIPK4 Homo sapiens P57078-2
Y2H Array
32296183
Intra
VWC2L B2RUY7 RIPK4 Homo sapiens P57078-2
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 C17orf50 Homo sapiens Q8WW18
Y2H Array
32296183
Intra
VWC2L B2RUY7 C17orf50 Homo sapiens Q8WW18
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 C17orf50 Homo sapiens Q8WW18
Validated Y2H
32296183
Intra
VWC2L B2RUY7 CEMP1 Homo sapiens Q6PRD7
Validated Y2H
32296183
Intra
VWC2L B2RUY7 CEMP1 Homo sapiens Q6PRD7
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 CEMP1 Homo sapiens Q6PRD7
Y2H Array
32296183
Intra
VWC2L B2RUY7 NR4A3 Homo sapiens Q92570
Validated Y2H
32296183
Intra
VWC2L B2RUY7 NR4A3 Homo sapiens Q92570
Y2H Array
32296183
Intra
VWC2L B2RUY7 NR4A3 Homo sapiens Q92570
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
VWC2L B2RUY7 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
VWC2L B2RUY7 DEFB112 Homo sapiens Q30KQ8
Y2H Array
32296183
Intra
VWC2L B2RUY7 DEFB112 Homo sapiens Q30KQ8
Validated Y2H
32296183
Intra
VWC2L B2RUY7 DEFB112 Homo sapiens Q30KQ8
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
VWC2L B2RUY7 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 TYRO3 Homo sapiens Q06418
Validated Y2H
32296183
Intra
VWC2L B2RUY7 TYRO3 Homo sapiens Q06418
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 TYRO3 Homo sapiens Q06418
Y2H Array
32296183
Intra
VWC2L B2RUY7 TRIM42 Homo sapiens Q8IWZ5
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 TRIM42 Homo sapiens Q8IWZ5
Validated Y2H
32296183
Intra
VWC2L B2RUY7 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
32296183
Intra
VWC2L B2RUY7 CRCT1 Homo sapiens Q9UGL9
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 CRCT1 Homo sapiens Q9UGL9
Validated Y2H
32296183
Intra
VWC2L B2RUY7 CRCT1 Homo sapiens Q9UGL9
Y2H Array
32296183
Intra
VWC2L B2RUY7 ZNF20 Homo sapiens P17024
Y2H Array
32296183
Intra
VWC2L B2RUY7 ZNF20 Homo sapiens P17024
Validated Y2H
32296183
Intra
VWC2L B2RUY7 ZNF20 Homo sapiens P17024
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 FBXO34 Homo sapiens Q9NWN3
Validated Y2H
32296183
Intra
VWC2L B2RUY7 FBXO34 Homo sapiens Q9NWN3
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 FBXO34 Homo sapiens Q9NWN3
Y2H Array
32296183
Intra
VWC2L B2RUY7 C22orf39 Homo sapiens Q6P5X5
Validated Y2H
32296183
Intra
VWC2L B2RUY7 C22orf39 Homo sapiens Q6P5X5
Y2H Array
32296183
Intra
VWC2L B2RUY7 C22orf39 Homo sapiens Q6P5X5
Y2H Prey Pooling
32296183
Intra
VWC2L B2RUY7 OTX1 Homo sapiens P32242
Validated Y2H
27107012
Intra
VWC2L B2RUY7 OTX1 Homo sapiens P32242
Validated Y2H
32296183
Intra
VWC2L B2RUY7 OTX1 Homo sapiens P32242
BFG-2H
27107012
Intra
VWC2L B2RUY7 OTX1 Homo sapiens P32242
Y2H Array
32296183
Intra
VWC2L B2RUY7 HOXA1 Homo sapiens P49639
Validated Y2H
32296183
Intra
VWC2L B2RUY7 FHL3 Homo sapiens Q13643
BFG-2H
27107012
Intra
VWC2L B2RUY7 LCE3A Homo sapiens Q5TA76
Validated Y2H
32296183
Intra
VWC2L B2RUY7 LCE3A Homo sapiens Q5TA76
Y2H Array
32296183
Intra
VWC2L B2RUY7 LCE3A Homo sapiens Q5TA76
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16429 VWC2L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21805 Vwc2l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28321 Vwc2l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown