2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CXC Chemokines
  6. ENA-78

ENA-78

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CXCL5, also known as neutrophil activating peptide 78 (ENA‐78), is a CXC chemokine containing ELR motif. CXCL5 promotes angiogenesis through interaction with its specific receptor CXCR2. CXCL5 is expressed by many immune cells, such as macrophages, eosinophils, and non-immune cells including mesothelial cells, and fibroblasts.CXCL5/CXCR2 axis not only contributes to the recruitment of neutrophils but also regulates the function of neutrophils in melanoma[1][2].
CXCL5 can recruit cells, such as T/B lymphocytes and eosinophils from the immune system to the corresponding regions during immune response. Besides, it also participates in promoting the adhesion and remodeling of connective tissues. CXCL5 is highly expressed in various tumor tissues. CXCL5 can be used as a potential indicator of tumor prognosis. In tumor microenvironment (TME), CXCL5 binds to its receptors, such as CXCR2, to participate in the recruitment of immune cells and promote angiogenesis, tumor growth, and metastasis. Mesenchymal stem cells (MSCs) activated by acidic TME or TNF‐α can secrete CXCL5 and other pro‐inflammatory factors. Besides, cancer‐associated mesothelial cells, which are generated by plasminogen activator inhibitor‐1 (PAI‐1), can secrete IL‐8 and CXCL5 via the NF-κB signaling pathway and thereby promoting peritoneal metastasis. Adipose tissue‐derived stem cells (ASCs) secrete CXCL5 which subsequently promotes tumor growth and affects the development of breast tumors[2].

Subscribe Now to the List of Recombinant Proteins

Cat. No. Product Name / Synonyms Species Source
  • HY-P7157
    ENA-78/CXCL5 Protein, Human (HEK293)

    rHuENA-78/CXCL5; ENA78; SCYB5

    		Human HEK293
    CXCL5, also known as neutrophil activating peptide 78 (ENA‐78), is a CXC chemokine containing ELR motif. CXCL5 promotes angiogenesis through interaction with its specific receptor CXCR2. CXCL5 is expressed by many immune cells, such as macrophages, eosinophils, and non-immune cells including mesothelial cells, and fibroblasts.CXCL5/CXCR2 axis not only contributes to the recruitment of neutrophils but also regulates the function of neutrophils in melanoma. ENA-78/CXCL5 Protein, Human (HEK293) is produced in HEK293 cells, and consists of 78 amino acids (A37-N114).
  • HY-P72791
    LIX/CXCL5 Protein, Mouse

    C-X-C motif chemokine 5; Cytokine LIX; Cxcl5; Scyb5

    		Mouse E. coli
    CXCL5, also known as neutrophil activating peptide 78 (ENA‐78), is a CXC chemokine containing ELR motif. CXCL5 promotes angiogenesis through interaction with its specific receptor CXCR2. CXCL5 is expressed by many immune cells, such as macrophages, eosinophils, and non-immune cells including mesothelial cells, and fibroblasts.CXCL5/CXCR2 axis not only contributes to the recruitment of neutrophils but also regulates the function of neutrophils in melanoma. LIX/CXCL5 Protein, Mouse is produced in E.coil, and consists of 92 amino acids (A41-Q132).
  • HY-P7158
    ENA-78/CXCL5 Protein, Human

    rHuENA-78/CXCL5; ENA78; SCYB5

    		Human E. coli
    CXCL5, also known as neutrophil activating peptide 78 (ENA‐78), is a CXC chemokine containing ELR motif. CXCL5 promotes angiogenesis through interaction with its specific receptor CXCR2. CXCL5 is expressed by many immune cells, such as macrophages, eosinophils, and non-immune cells including mesothelial cells, and fibroblasts.CXCL5/CXCR2 axis not only contributes to the recruitment of neutrophils but also regulates the function of neutrophils in melanoma. ENA-78/CXCL5 Protein, Human is produced in E.coil, and consists of 70 amino acids (R45-N114).
  • HY-P7383
    LIX/CXCL5 Protein, Mouse (74a.a, CHO)

    rMuLIX/CXCL5, 74a.a.; LIX; C-X-C motif chemokine 5; SCYB5

    		Mouse CHO
    CXCL5, also known as neutrophil activating peptide 78 (ENA‐78), is a CXC chemokine containing ELR motif. CXCL5 promotes angiogenesis through interaction with its specific receptor CXCR2. CXCL5 is expressed by many immune cells, such as macrophages, eosinophils, and non-immune cells including mesothelial cells, and fibroblasts.CXCL5/CXCR2 axis not only contributes to the recruitment of neutrophils but also regulates the function of neutrophils in melanoma. LIX/CXCL5 Protein, Mouse (74a.a, CHO) is produced in CHO cells, and consists of 74 amino acids (V45-A118).
  • HY-P700047AF
    Animal-Free ENA-78/CXCL5 Protein, Human (His)

    ENA-78/CXCL5; ENA78; SCYB5

    		Human E. coli
    The CXCL5 protein is critical in neutrophil activation and displays enhanced chemotactic activity on neutrophils, with increased potency of ENA-78(8-78) and ENA-78(9-78) isoforms three times. Structurally, CXCL5 exists as monomers and homodimers, emphasizing its multifunctional molecular configuration. Animal-Free ENA-78/CXCL5 Protein, Human (His) is the recombinant human-derived animal-FreeENA-78/CXCL5 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free ENA-78/CXCL5 Protein, Human (His) is 70 a.a., with molecular weight of ~8.51 kDa.
  • HY-P700173AF
    Animal-Free LIX/CXCL5 Protein, Mouse (His)

    rMuLIX/CXCL5, 74a.a.; LIX; C-X-C motif chemokine 5; SCYB5

    		Mouse E. coli
    LIX/CXCL5 Protein potentially recruits inflammatory cells to injured or infected tissue, indicating a role in the immune response. Both GCP-2(1-78) and the more potent GCP-2(9-78) variants attract and activate neutrophils. Structurally, the protein can exist as a monomer and form homodimers, showcasing versatility and potential molecular interactions. LIX/CXCL5's ability to attract and activate neutrophils emphasizes its significance in orchestrating immune responses and cellular processes associated with inflammation. Animal-Free LIX/CXCL5 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeLIX/CXCL5 protein, expressed by E. coli, with N-His labeled tag. The total length of Animal-Free LIX/CXCL5 Protein, Mouse (His) is 74 a.a., with molecular weight of ~8.92 kDa.
Cat. No. Product Name Effect Purity