FBXO34 - F-box protein 34 Gene

Also Known as Fbx34; CGI-301

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55030

Summary

Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Ubiquitous expression in testis (RPKM 12.2), esophagus (RPKM 11.1) and 25 other tissues.

FBXO34 Products (2)

mRNA Protein Name
NM_017943.4 NP_060413.2 F-box only protein 34
NM_152231.2 NP_689417.1 F-box only protein 34

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO34 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FBXO34 Q9NWN3 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
FBXO34 Q9NWN3 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
FBXO34 Q9NWN3 KRTAP12-4 Homo sapiens P60329
MAPPIT
32296183
Intra
FBXO34 Q9NWN3 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
FBXO34 Q9NWN3 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
FBXO34 Q9NWN3 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
31515488
Intra
FBXO34 Q9NWN3 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra
FBXO34 Q9NWN3 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra
FBXO34 Q9NWN3 FGF14 Homo sapiens Q92915-2
Y2H Array
32296183
Intra
FBXO34 Q9NWN3 FGF14 Homo sapiens Q92915-2
Y2H Prey Pooling
32296183
Intra
FBXO34 Q9NWN3 MDFI Homo sapiens Q99750
Validated Y2H
25416956
Intra
FBXO34 Q9NWN3 MTUS2 Homo sapiens Q5JR59
Y2H Prey Pooling
25416956
Intra
FBXO34 Q9NWN3 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
Intra
FBXO34 Q9NWN3 MTUS2 Homo sapiens Q5JR59
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04802 FBXO30 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04801 FBXO3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04803 FBXO31 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04804 FBXO32 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04805 FBXO38 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04806 FBXO4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04809 FBXO44 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18517 Fbxo4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20156 Fbxo32 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21127 Fbxo44 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24999 Fbxo4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26660 Fbxo32 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27645 Fbxo44 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown