PATL1 - PAT1 homolog 1, processing body mRNA decay factor Gene

Homo sapiens

Also known as Pat1b; hPat1b

Gene ID: 219988 | Gene type: protein coding

About PATL1

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:59,636,716-59,669,037 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 16.7), placenta (RPKM 9.5) and 25 other tissues.

Summary

Enables poly(G) binding activity and poly(U) RNA binding activity. Involved in P-body assembly and deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in P-body and cytosol. Colocalizes with CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

PATL1 Products(1)

mRNA	Protein	Name
NM_152716.3	NP_689929.2	protein PAT1 homolog 1

PATL1 Protein Structure

PAT1

0
200
400
600
770 a.a.

Protein Preferred Names

Protein Names

protein PAT1 homolog 1

PAT1-like protein 1

Related Diseases

Diseases

Alias

Hermansky-Pudlak Syndrome 7

HPS7	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Delta Storage Pool Disease	Hermansky-Pudlak Syndrome, Type 7
Platelet Storage Pool Deficiency	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Retinitis Pigmentosa 13

RP13	Retinitis Pigmentosa-13
Retinitis Pigmentosa, Type 13

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10084	PATL1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PATL1	VGNC	VGNC:44272
Macaca mulatta	PATL1	VGNC	VGNC:75684
Mus musculus	PATL1	MGD	MGI:2147679
Felis catus	PATL1	VGNC	VGNC:64049
Bos taurus	PATL1	VGNC	VGNC:32593
Rattus norvegicus	PATL1	RGD	RGD:1305514

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