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  3. DCP1A - decapping mRNA 1A Gene

DCP1A - decapping mRNA 1A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SMIF; SMAD4IP1; HSA275986; Nbla00360

Gene ID: 55802 | Gene type: protein coding

About DCP1A

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:53,283,429-53,347,543 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 10.4), ovary (RPKM 7.6) and 25 other tissues.

Summary

Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping Enzyme. This protein and another decapping Enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

DCP1A Products(5)

mRNA Protein Name
NM_001290204.2 NP_001277133.1 mRNA-decapping enzyme 1A isoform b
NM_001290205.2 NP_001277134.1 mRNA-decapping enzyme 1A isoform c
NM_001290206.2 NP_001277135.1 mRNA-decapping enzyme 1A isoform d
NM_001290207.2 NP_001277136.1 mRNA-decapping enzyme 1A isoform e
NM_018403.7 NP_060873.4 mRNA-decapping enzyme 1A isoform a

DCP1A Protein Structure

DCP1

DCP1: Dcp1-like decapping family (6 - 126)

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  • 582 a.a.
Protein Preferred Names Protein Names

mRNA-decapping enzyme 1A

DCP1 decapping enzyme homolog A

Related Diseases

Diseases Alias
Metaphyseal Chondrodysplasia, Schmid Type

MCDS

Schmid Metaphyseal Chondrodysplasia

Metaphyseal Chondrodysplasia Schmid Type

Spondylometaphyseal Dysplasia, Japanese Type

Japanese Type Spondylometaphyseal Dysplasia

Schmid Type Metaphyseal Dysplasia

Metaphyseal Chondrodysplasia Type Schmid

Schmid Type Metaphyseal Chondrodysplasia

SMCD

Chondrodysplasia, Metaphyseal, Schmid Type

Corneal Dystrophy, Subepithelial Mucinous
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03584 DCP1A Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DCP1A VGNC VGNC:71668
Canis familiaris DCP1A VGNC VGNC:39808
Mus musculus DCP1A MGD MGI:1923151
Rattus norvegicus DCP1A RGD RGD:1561298
Bos taurus DCP1A VGNC VGNC:27919
Felis catus DCP1A VGNC VGNC:61372