NSMAF - neutral sphingomyelinase activation associated factor Gene

Also Known as FAN; GRAMD5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8439

About NSMAF

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:58,583,504-58,659,853 (from NCBI)

This gene has 18 transcripts (splice variants), 217 orthologues and 7 paralogues. Ubiquitous expression in lymph node (RPKM 12.0), appendix (RPKM 10.7) and 25 other tissues.

Summary

This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

NSMAF Products (24)

mRNA Protein Name
NM_001144772.1 NP_001138244.1 protein FAN isoform 2
NM_001412988.1 NP_001399917.1 protein FAN isoform 3
NM_001412989.1 NP_001399918.1 protein FAN isoform 4
NM_001412990.1 NP_001399919.1 protein FAN isoform 5
NM_001412991.1 NP_001399920.1 protein FAN isoform 6
NM_001412992.1 NP_001399921.1 protein FAN isoform 7
NM_001412993.1 NP_001399922.1 protein FAN isoform 8
NM_001412994.1 NP_001399923.1 protein FAN isoform 9
NM_001412995.1 NP_001399924.1 protein FAN isoform 10
NM_001412996.1 NP_001399925.1 protein FAN isoform 6
NM_001412997.1 NP_001399926.1 protein FAN isoform 6
NM_001412998.1 NP_001399927.1 protein FAN isoform 11
NM_001412999.1 NP_001399928.1 protein FAN isoform 6
NM_001413000.1 NP_001399929.1 protein FAN isoform 6
NM_001413001.1 NP_001399930.1 protein FAN isoform 6
NM_001413002.1 NP_001399931.1 protein FAN isoform 12
NM_001413003.1 NP_001399932.1 protein FAN isoform 6
NM_001413004.1 NP_001399933.1 protein FAN isoform 6
NM_001413005.1 NP_001399934.1 protein FAN isoform 9
NM_001413006.1 NP_001399935.1 protein FAN isoform 13
NM_001413007.1 NP_001399936.1 protein FAN isoform 14
NM_001413008.1 NP_001399937.1 protein FAN isoform 14
NM_001413009.1 NP_001399938.1 protein FAN isoform 15
NM_003580.4 NP_003571.2 protein FAN isoform 1

NSMAF Protein Structure

GRAM

GRAM: GRAM domain (180 - 246)

Beach

Beach: Beige/BEACH domain (303 - 575)

WD40

WD40: WD domain, G-beta repeat (709 - 740)

WD40

WD40: WD domain, G-beta repeat (799 - 832)

WD40

WD40: WD domain, G-beta repeat (882 - 914)

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  • 800
  • 917 a.a.
Protein Preferred Names Protein Names

protein FAN

  • factor associated with N-SMase activation

NSMAF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NSMAF Q92636 ACTB Homo sapiens P60709
Pull Down
17599063
Intra
NSMAF Q92636 DCP1B Homo sapiens Q8IZD4
Pull Down
26133670
Intra
NSMAF Q92636 GABARAP Homo sapiens O95166
Pull Down
20562859
Intra
NSMAF Q92636 GABARAPL1 Homo sapiens Q9H0R8
Anti Tag CoIP
33961781
Intra
NSMAF Q92636 GABARAPL1 Homo sapiens Q9H0R8
Anti Tag CoIP
28514442
Intra
NSMAF Q92636 GABARAPL1 Homo sapiens Q9H0R8
Pull Down
20562859
Intra
NSMAF Q92636 VASP Homo sapiens P50552
Pull Down
17599063
Cross
NSMAF Q92636 dcp1_arath Arabidopsis thaliana Q9SJF3
Y2H
26133670
Cross
NSMAF Q92636 dcp1_arath Arabidopsis thaliana Q9SJF3
Pull Down
26133670
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09596 NSMAF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22691 Nsmaf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29205 Nsmaf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NSMAF VGNC VGNC:32278
Mus musculus NSMAF MGD MGI:1341864
Felis catus NSMAF VGNC VGNC:68573
Rattus norvegicus NSMAF RGD RGD:727868
Canis familiaris NSMAF VGNC VGNC:43987
Others NSMAF NCBI