2. Gene
  3. NSMAF - neutral sphingomyelinase activation associated factor Gene

NSMAF - neutral sphingomyelinase activation associated factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as FAN; GRAMD5

Gene ID: 8439 | Gene type: protein coding

About NSMAF

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:58,583,504-58,659,853 (from NCBI)

This gene has 18 transcripts (splice variants), 217 orthologues and 7 paralogues. Ubiquitous expression in lymph node (RPKM 12.0), appendix (RPKM 10.7) and 25 other tissues.

Summary

This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

NSMAF Products(24)

mRNA Protein Name
NM_001144772.1 NP_001138244.1 protein FAN isoform 2
NM_001412988.1 NP_001399917.1 protein FAN isoform 3
NM_001412989.1 NP_001399918.1 protein FAN isoform 4
NM_001412990.1 NP_001399919.1 protein FAN isoform 5
NM_001412991.1 NP_001399920.1 protein FAN isoform 6
NM_001412992.1 NP_001399921.1 protein FAN isoform 7
NM_001412993.1 NP_001399922.1 protein FAN isoform 8
NM_001412994.1 NP_001399923.1 protein FAN isoform 9
NM_001412995.1 NP_001399924.1 protein FAN isoform 10
NM_001412996.1 NP_001399925.1 protein FAN isoform 6
NM_001412997.1 NP_001399926.1 protein FAN isoform 6
NM_001412998.1 NP_001399927.1 protein FAN isoform 11
NM_001412999.1 NP_001399928.1 protein FAN isoform 6
NM_001413000.1 NP_001399929.1 protein FAN isoform 6
NM_001413001.1 NP_001399930.1 protein FAN isoform 6
NM_001413002.1 NP_001399931.1 protein FAN isoform 12
NM_001413003.1 NP_001399932.1 protein FAN isoform 6
NM_001413004.1 NP_001399933.1 protein FAN isoform 6
NM_001413005.1 NP_001399934.1 protein FAN isoform 9
NM_001413006.1 NP_001399935.1 protein FAN isoform 13
NM_001413007.1 NP_001399936.1 protein FAN isoform 14
NM_001413008.1 NP_001399937.1 protein FAN isoform 14
NM_001413009.1 NP_001399938.1 protein FAN isoform 15
NM_003580.4 NP_003571.2 protein FAN isoform 1

NSMAF Protein Structure

GRAM

GRAM: GRAM domain (180 - 246)

Beach

Beach: Beige/BEACH domain (303 - 575)

WD40

WD40: WD domain, G-beta repeat (709 - 740)

WD40

WD40: WD domain, G-beta repeat (799 - 832)

WD40

WD40: WD domain, G-beta repeat (882 - 914)

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  • 917 a.a.
Protein Preferred Names Protein Names

protein FAN

factor associated with N-SMase activation

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09596 NSMAF Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NSMAF VGNC VGNC:32278
Mus musculus NSMAF MGD MGI:1341864
Felis catus NSMAF VGNC VGNC:68573
Rattus norvegicus NSMAF RGD RGD:727868
Canis familiaris NSMAF VGNC VGNC:43987