DCP1B - decapping mRNA 1B Gene

Also Known as DCP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 196513

About DCP1B

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:1,941,591-2,004,457 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 212 orthologues and 1 paralogue. Broad expression in testis (RPKM 7.9), endometrium (RPKM 5.4) and 25 other tissues.

Summary

This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

DCP1B Products (2)

mRNA Protein Name
NM_001319292.2 NP_001306221.1 mRNA-decapping enzyme 1B isoform 2
NM_152640.5 NP_689853.3 mRNA-decapping enzyme 1B isoform 1

DCP1B Protein Structure

DCP1

DCP1: Dcp1-like decapping family (13 - 130)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 617 a.a.
Protein Preferred Names Protein Names

mRNA-decapping enzyme 1B

  • DCP1 decapping enzyme homolog B

DCP1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DCP1B Q8IZD4 NSMAF Homo sapiens Q92636
Y2H
26133670
Intra
DCP1B Q8IZD4 BAG4 Homo sapiens O95429
Lumier
25036637
Intra
DCP1B Q8IZD4 DCP1A Homo sapiens Q9NPI6
Anti Tag CoIP
16364915
Intra
DCP1B Q8IZD4 DCP1A Homo sapiens Q9NPI6
Anti Tag CoIP
35271311
Intra
DCP1B Q8IZD4 DCP1A Homo sapiens Q9NPI6
Anti Tag CoIP
25036637
Intra
DCP1B Q8IZD4 DCP2 Homo sapiens Q8IU60
Anti Tag CoIP
16364915
Intra
DCP1B Q8IZD4 EDC3 Homo sapiens Q96F86
Anti Tag CoIP
16364915
Intra
DCP1B Q8IZD4 EDC3 Homo sapiens Q96F86
Y2H Array
29892012
Intra
DCP1B Q8IZD4 EDC3 Homo sapiens Q96F86
BN-PAGE
26184334
Intra
DCP1B Q8IZD4 EDC3 Homo sapiens Q96F86
Anti Tag CoIP
35271311
Intra
DCP1B Q8IZD4 EDC3 Homo sapiens Q96F86
Anti Tag CoIP
25036637
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3

  • Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 3

  • EEC3

  • Eec Syndrome 3

  • Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03585 DCP1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DCP1B VGNC VGNC:39809
Rattus norvegicus DCP1B RGD RGD:1562214
Macaca mulatta DCP1B VGNC VGNC:71699
Felis catus DCP1B VGNC VGNC:61373
Bos taurus DCP1B VGNC VGNC:27920
Mus musculus DCP1B MGD MGI:2442404
Others DCP1B NCBI