DCP2 - decapping mRNA 2 Gene

Also Known as NUDT20

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 167227

About DCP2

Cytogenetic location: 5q22.2 Genomic coordinates (GRCh38): 5:112,976,798-113,022,195 (from NCBI)

This gene has 9 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in lymph node (RPKM 7.7), placenta (RPKM 6.8) and 24 other tissues.

Summary

The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

DCP2 Products (2)

mRNA	Protein	Name
NM_001242377.2	NP_001229306.1	m7GpppN-mRNA hydrolase isoform 2
NM_152624.6	NP_689837.2	m7GpppN-mRNA hydrolase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	IDA IDA: Inferred from direct assay	21070968	GOA
enables 5'-3' RNA exonuclease activity	IMP IMP: Inferred from mutant phenotype	26950371	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12417715	GOA
enables telomerase RNA binding	IPI IPI: Inferred from physical interaction	26950371	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in histone mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	18172165	GOA
involved in mRNA catabolic process	IDA IDA: Inferred from direct assay	21070968	GOA
involved in negative regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	26950371	GOA
involved in regulation of mRNA stability	IDA IDA: Inferred from direct assay	28002401	GOA
involved in regulation of telomerase RNA localization to Cajal body	IMP IMP: Inferred from mutant phenotype	26950371	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	20616046	GOA
part of RISC complex	IDA IDA: Inferred from direct assay	20616046	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCP2 Protein Structure

DCP2

NUDIX

0
100
200
300
400
420 a.a.

Protein Preferred Names	Protein Names
m7GpppN-mRNA hydrolase	DCP2 decapping enzyme homolog

DCP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DCP2	Q8IU60	EDC4	Homo sapiens	Q6P2E9	Anti Tag CoIP	33961781
Intra	DCP2	Q8IU60	EDC4	Homo sapiens	Q6P2E9	Anti Tag CoIP	16364915
Intra	DCP2	Q8IU60	EDC4	Homo sapiens	Q6P2E9	Anti Tag CoIP	24510189
Intra	DCP2	Q8IU60	EDC4	Homo sapiens	Q6P2E9	Anti Tag CoIP	35271311
Intra	DCP2	Q8IU60	EDC4	Homo sapiens	Q6P2E9	Y2H	15231747
Intra	DCP2	Q8IU60	UPF1	Homo sapiens	Q92900	Anti Tag CoIP	12417715
Intra	DCP2	Q8IU60	DCP1A	Homo sapiens	Q9NPI6	Y2H	15231747
Intra	DCP2	Q8IU60	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	33961781
Intra	DCP2	Q8IU60	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	12417715
Intra	DCP2	Q8IU60	DCP1A	Homo sapiens	Q9NPI6	Pull Down	24510189
Intra	DCP2	Q8IU60	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	24510189
Intra	DCP2	Q8IU60	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	33961781
Intra	DCP2	Q8IU60	DCP1B	Homo sapiens	Q8IZD4	Y2H	15231747

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145969A	β-S-ARCA triammonium		99.48%	Unkown
HY-141472	7-Methylguanosine 5'-diphosphate sodium		97.10%	Unkown
HY-145969	β-S-ARCA		/	Unkown
HY-178672A	ARCA triammonium solution (100 mM)		/	Unkown
HY-RS03586	DCP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DCP2	VGNC	VGNC:27921
Felis catus	DCP2	VGNC	VGNC:61374
Rattus norvegicus	DCP2	RGD	RGD:1562909
Canis familiaris	DCP2	VGNC	VGNC:39810
Macaca mulatta	DCP2	VGNC	VGNC:71700
Mus musculus	DCP2	MGD	MGI:1917890
Others	DCP2	NCBI