EDC4 - enhancer of mRNA decapping 4 Gene

Also Known as GE1; Ge-1; RCD8; HEDL5; HEDLS; RCD-8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23644

About EDC4

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,873,052-67,884,499 (from NCBI)

This gene has 14 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in testis (RPKM 17.8), bone marrow (RPKM 15.0) and 25 other tissues.

Summary

Predicted to be involved in deadenylation-independent decapping of nuclear-transcribed mRNA. Located in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

EDC4 Products (1)

mRNA Protein Name
NM_014329.5 NP_055144.3 enhancer of mRNA-decapping protein 4

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15231747 GOA
Cellular Component GO Annotation Evidence References Source
located in P-body IDA
IDA: Inferred from direct assay
20826699 GOA
located in nucleus IDA
IDA: Inferred from direct assay
7520377 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

enhancer of mRNA-decapping protein 4

  • autoantigen Ge-1

EDC4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EDC4 Q6P2E9 NBDY Homo sapiens A0A0U1RRE5
Crosslink
27918561
Intra
EDC4 Q6P2E9 NBDY Homo sapiens A0A0U1RRE5
Anti Tag CoIP
27918561
Intra
EDC4 Q6P2E9 NBDY Homo sapiens A0A0U1RRE5
Pull Down
27918561
Intra
EDC4 Q6P2E9 XRN1 Homo sapiens Q8IZH2
Pull Down
24510189
Intra
EDC4 Q6P2E9 XRN1 Homo sapiens Q8IZH2
Anti Bait CoIP
20584987
Intra
EDC4 Q6P2E9 XRN1 Homo sapiens Q8IZH2
Anti Tag CoIP
24510189
Intra
EDC4 Q6P2E9 XRN1 Homo sapiens Q8IZH2
Anti Tag CoIP
35271311
Intra
EDC4 Q6P2E9 DCP1A Homo sapiens Q9NPI6
IF
16364915
Intra
EDC4 Q6P2E9 DCP1A Homo sapiens Q9NPI6
Anti Tag CoIP
24510189
Intra
EDC4 Q6P2E9 DCP1A Homo sapiens Q9NPI6
Anti Tag CoIP
35271311
Intra
EDC4 Q6P2E9 DCP1A Homo sapiens Q9NPI6
Anti Tag CoIP
16364915
Intra
EDC4 Q6P2E9 DCP2 Homo sapiens Q8IU60
Anti Tag CoIP
16364915
Intra
EDC4 Q6P2E9 DCP2 Homo sapiens Q8IU60
Anti Tag CoIP
24510189
Intra
EDC4 Q6P2E9 DCP2 Homo sapiens Q8IU60
Pull Down
24510189
Intra
EDC4 Q6P2E9 DCP2 Homo sapiens Q8IU60-2
Anti Tag CoIP
16364915
Intra
EDC4 Q6P2E9 COASY Homo sapiens Q13057
Anti Bait CoIP
22982864
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Human Granulocytic Anaplasmosis

  • Human Granulocytic Ehrlichiosis

  • Hge

  • Human Ehrlichial Infection, Human Granulocytic Type

  • Human Anaplasmosis Due To Anaplasma Phagocytophilum
Spherocytosis, Type 2

  • Hereditary Spherocytosis Type 2

  • SPH2

  • Spherocytosis, Hereditary, 2

  • Hs2

  • Hereditary Spherocytosis 2

  • Spherocytosis 2

  • Spherocytosis, Type 2, Autosomal Dominant
Ulnar Neuropathy

  • Ulnar Neuropathies
Thoracic Outlet Syndrome

  • Tos

  • Tos - Thoracic Outlet Syndrome

  • Thoracic Outlet Syndromes

  • Thoracic Outlet Compression Syndrome
Ehrlichiosis

  • Human Ehrlichiosis

  • He

  • Hey
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04156 EDC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22151 Edc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28672 Edc4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta EDC4 VGNC VGNC:72058
Bos taurus EDC4 VGNC VGNC:28321
Felis catus EDC4 VGNC VGNC:61721
Mus musculus EDC4 MGD MGI:2446249
Rattus norvegicus EDC4 RGD RGD:1562009
Canis familiaris EDC4 VGNC VGNC:40193
Others EDC4 NCBI