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EDC3 - enhancer of mRNA decapping 3 Gene

Also Known as YJDC; LSM16; MRT50; YJEFN2; hYjeF_N2-15q23

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80153

About EDC3

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,630,558-74,696,024 (from NCBI)

This gene has 19 transcripts (splice variants), 247 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 14.2), ovary (RPKM 7.5) and 25 other tissues.

Summary

This gene encodes a protein that is important in mRNA degradation. The encoded protein is a component of a decapping complex that promotes efficient removal of the monomethylguanosine (m7G) cap from mRNAs, as part of the 5' to 3' mRNA decay pathway. Mutations in this gene have been identified in human patients with an autosomal recessive form of intellectual disability. [provided by RefSeq, May 2017]

EDC3 Products (5)

mRNA	Protein	Name
NM_001142443.3	NP_001135915.1	enhancer of mRNA-decapping protein 3 isoform 1
NM_001142444.3	NP_001135916.1	enhancer of mRNA-decapping protein 3 isoform 1
NM_001351378.2	NP_001338307.1	enhancer of mRNA-decapping protein 3 isoform 1
NM_001351379.2	NP_001338308.1	enhancer of mRNA-decapping protein 3 isoform 2
NM_025083.5	NP_079359.2	enhancer of mRNA-decapping protein 3 isoform 1

EDC3 Protein Structure

LSM14

FDF

YjeF_N

0
100
200
300
400
508 a.a.

Protein Preferred Names	Protein Names
enhancer of mRNA-decapping protein 3	LSM16 homolog (EDC3, S. cerevisiae)

EDC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EDC3	Q96F86	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	EDC3	Q96F86	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	EDC3	Q96F86	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	25416956
Intra	EDC3	Q96F86	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	EDC3	Q96F86	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
Intra	EDC3	Q96F86	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
Intra	EDC3	Q96F86	DDX6	Homo sapiens	P26196	Y2H Array	32296183
Intra	EDC3	Q96F86	DDX6	Homo sapiens	P26196	Anti Tag CoIP	16364915
Intra	EDC3	Q96F86	DDX6	Homo sapiens	P26196	Y2H Array	25416956
Intra	EDC3	Q96F86	DDX6	Homo sapiens	P26196	Anti Tag CoIP	33961781
Intra	EDC3	Q96F86	DDX6	Homo sapiens	P26196	Y2H Prey Pooling	32296183
Intra	EDC3	Q96F86	DDX6	Homo sapiens	P26196	Anti Tag CoIP	35271311
Intra	EDC3	Q96F86	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	28514442
Intra	EDC3	Q96F86	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	33961781
Intra	EDC3	Q96F86	DCP1A	Homo sapiens	Q9NPI6	Y2H Prey Pooling	32296183
Intra	EDC3	Q96F86	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	35271311
Intra	EDC3	Q96F86	DCP1A	Homo sapiens	Q9NPI6	Validated Y2H	32296183
Intra	EDC3	Q96F86	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	16364915
Intra	EDC3	Q96F86	DCP1A	Homo sapiens	Q9NPI6	BFG-2H	27107012
Intra	EDC3	Q96F86	DCP1A	Homo sapiens	Q9NPI6	Y2H Array	32296183
Intra	EDC3	Q96F86	DCP1B	Homo sapiens	Q8IZD4	Validated Y2H	25416956
Intra	EDC3	Q96F86	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	33961781
Intra	EDC3	Q96F86	DCP1B	Homo sapiens	Q8IZD4	Y2H Array	25416956
Intra	EDC3	Q96F86	DCP1B	Homo sapiens	Q8IZD4	Y2H	21516116
Intra	EDC3	Q96F86	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	28514442
Intra	EDC3	Q96F86	DCP1B	Homo sapiens	Q8IZD4	Y2H Prey Pooling	25416956
Intra	EDC3	Q96F86	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	35271311
Intra	EDC3	Q96F86	ANXA10	Homo sapiens	Q9UJ72	Y2H Prey Pooling	32296183
Intra	EDC3	Q96F86	ANXA10	Homo sapiens	Q9UJ72	Y2H Array	31515488
Intra	EDC3	Q96F86	ANXA10	Homo sapiens	Q9UJ72	Validated Y2H	32296183
Intra	EDC3	Q96F86	ANXA10	Homo sapiens	Q9UJ72	Y2H Array	32296183
Intra	EDC3	Q96F86	ANXA10	Homo sapiens	Q9UJ72	Y2H Prey Pooling	25416956
Intra	EDC3	Q96F86	ANXA10	Homo sapiens	Q9UJ72	Y2H	21516116

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Recessive 50	MRT50 Mental Retardation, Autosomal Recessive 50 Autosomal Recessive Intellectual Developmental Disorder 50 Mental Retardation, Autosomal Recessive, Type 50
Autosomal Recessive Non-Syndromic Intellectual Disability	Ar-Nsid Ns-Arid
Epiphyseal Dysplasia, Multiple, 3	EDM3 Multiple Epiphyseal Dysplasia 3 Epiphyseal Dysplasia, Multiple, 3, With Or Without Myopathy Multiple Epiphyseal Dysplasia 3 With Or Without Myopathy Epiphyseal Dysplasia Multiple 3 Dysplasia, Epiphyseal, Multiple, Type 3
Epiphyseal Dysplasia, Multiple, 4	EDM4 Multiple Epiphyseal Dysplasia 4 Multiple Epiphyseal Dysplasia With Clubfoot Multiple Epiphyseal Dysplasia Type 4 Multiple Epiphyseal Dysplasia, Autosomal Recessive Multiple Epiphyseal Dysplasia With Bilayered Patellae Med4 Polyepiphyseal Dysplasia Type 4 Rmed Autosomal Recessive Multiple Epiphyseal Dysplasia Multiple Epiphyseal Dysplasia With Bilateral Patellae Epiphyseal Dysplasia Multiple 4 Multiple Epiphyseal Dysplasia With Double-Layered Patella Dysplasia, Epiphyseal, Multiple, Type 4
Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16298	Edc3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04155	EDC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	EDC3	VGNC	VGNC:61720
Bos taurus	EDC3	VGNC	VGNC:28320
Rattus norvegicus	EDC3	RGD	RGD:1306898
Mus musculus	EDC3	MGD	MGI:2142951
Macaca mulatta	EDC3	VGNC	VGNC:72114
Canis familiaris	EDC3	VGNC	VGNC:40192
Others	EDC3	NCBI