PNRC2 - proline rich nuclear receptor coactivator 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55629

About PNRC2

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:23,959,164-23,963,462 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 68.8), lymph node (RPKM 67.1) and 25 other tissues.

Summary

Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in Golgi apparatus; P-body; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PNRC2 Products (1)

mRNA	Protein	Name
NM_017761.4	NP_060231.1	proline-rich nuclear receptor coactivator 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19150429	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA IDA: Inferred from direct assay	19150429	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	19150429	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19150429	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PNRC2 Protein Structure

PNRC

0
100
139 a.a.

Protein Preferred Names	Protein Names
proline-rich nuclear receptor coactivator 2

PNRC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PNRC2	Q9NPJ4	GALK1	Homo sapiens	P51570	Y2H Array	32296183
Intra	PNRC2	Q9NPJ4	UPF1	Homo sapiens	Q92900	Y2H	19150429
Intra	PNRC2	Q9NPJ4	UPF1	Homo sapiens	Q92900	Anti Tag CoIP	19150429
Intra	PNRC2	Q9NPJ4	UPF1	Homo sapiens	Q92900	Pull Down	19150429
Intra	PNRC2	Q9NPJ4	DCP1A	Homo sapiens	Q9NPI6	Y2H Array	32296183
Intra	PNRC2	Q9NPJ4	DCP1A	Homo sapiens	Q9NPI6	Y2H Prey Pooling	25416956
Intra	PNRC2	Q9NPJ4	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	19150429
Intra	PNRC2	Q9NPJ4	DCP1A	Homo sapiens	Q9NPI6	Y2H Prey Pooling	32296183
Intra	PNRC2	Q9NPJ4	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	33961781
Intra	PNRC2	Q9NPJ4	DCP1A	Homo sapiens	Q9NPI6	Y2H Array	31515488
Intra	PNRC2	Q9NPJ4	DCP1A	Homo sapiens	Q9NPI6	Confocal	19150429
Intra	PNRC2	Q9NPJ4	DCP1A	Homo sapiens	Q9NPI6	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Murray Valley Encephalitis	Australian Encephalitis Australian X Disease Encephalitis Australia Murray River Encephalitis Australian Arboencephalitis Australian X Disorder Mve - [Murray Valley Encephalitis]
Holoprosencephaly 3	HPE3 Hlp3 Holoprosencephaly-3 Holoprosencephaly, Type 3
Pancreatic Adenosquamous Carcinoma	Adenosquamous Carcinoma Of Pancreas Adenosquamous Carcinoma Of The Pancreas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10803	PNRC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PNRC2	VGNC	VGNC:100042
Rattus norvegicus	PNRC2	RGD	RGD:1642418
Mus musculus	PNRC2	MGD	MGI:106512
Felis catus	PNRC2	VGNC	VGNC:107602
Bos taurus	PNRC2	VGNC	VGNC:33099
Others	PNRC2	NCBI