BARX2 - BARX homeobox 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8538

About BARX2

Cytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:129,375,233-129,452,279 (from NCBI)

This gene has 2 transcripts (splice variants), 210 orthologues and 3 paralogues. Biased expression in esophagus (RPKM 46.6), salivary gland (RPKM 29.6) and 9 other tissues.

Summary

This gene encodes a member of the homeobox transcription factor family. A highly related protein in mouse has been shown to influence cellular processes that control cell adhesion and remodeling of the actin Cytoskeleton in myoblast fusion and chondrogenesis. The encoded protein may also play a role in Cancer progression. [provided by RefSeq, Jul 2008]

BARX2 Products (1)

mRNA Protein Name
NM_003658.5 NP_003649.2 homeobox protein BarH-like 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
10854790 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
14744868 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
14744868 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
14744868 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BARX2 Protein Structure

Homeobox

Homeobox: Homeobox domain (134 - 190)

  • 0
  • 100
  • 200
  • 279 a.a.
Protein Preferred Names Protein Names

homeobox protein BarH-like 2

  • BarH-like homeobox 2

BARX2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BARX2 Q9UMQ3 FHL2 Homo sapiens Q14192
Y2H Array
32296183
Intra
BARX2 Q9UMQ3 FHL2 Homo sapiens Q14192
Y2H Prey Pooling
32296183
Intra
BARX2 Q9UMQ3 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Intra
BARX2 Q9UMQ3 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Jacobsen Syndrome

  • Chromosome 11q Deletion Syndrome

  • Partial 11q Monosomy Syndrome

  • Jacobsen Distal 11q Deletion Syndrome

  • JBS

  • 11q Partial Monosomy Syndrome

  • Chromosome 11q Deletion

  • 11q Deletion

  • 11q Monosomy

  • Deletion 11q

  • Monosomy 11q

  • Partial Monosomy 11q

  • 11q Deletion Disorder

  • 11q Deletion Syndrome

  • 11q Terminal Deletion Disorder

  • 11q- Deletion Syndrome

  • 11q23 Deletion Disorder

  • Jacobsen Thrombocytopenia

  • 11q Terminal Deletion Syndrome

  • Del(11)(Q23.3)

  • Del(11)(Qter)

  • Distal Deletion 11q

  • Distal Monosomy 11q

  • Monosomy 11qter

  • Telomeric Deletion 11q

  • Paris-Trousseau Thrombocytopenia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01369 BARX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22403 Barx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28927 Barx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BARX2 RGD RGD:1584840
Bos taurus BARX2 VGNC VGNC:26424
Felis catus BARX2 VGNC VGNC:69123
Canis familiaris BARX2 VGNC VGNC:38383
Mus musculus BARX2 MGD MGI:109617
Macaca mulatta BARX2 VGNC VGNC:107424
Others BARX2 NCBI