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FADS6 - fatty acid desaturase 6 Gene

Also Known as FP18279

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 283985

About FADS6

This gene has 4 transcripts (splice variants), 190 orthologues and 3 paralogues. Biased expression in small intestine (RPKM 1.8), duodenum (RPKM 1.4) and 9 other tissues.

Summary

Predicted to enable oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. Predicted to be involved in lipid metabolic process. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

FADS6 Products (1)

mRNA	Protein	Name
NM_178128.6	NP_835229.3	fatty acid desaturase 6

FADS6 Protein Structure

FA_desaturase

0
100
200
300
350 a.a.

Protein Preferred Names	Protein Names
fatty acid desaturase 6	fatty acid desaturase domain family, member 6

FADS6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FADS6	Q8N9I5	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	FADS6	Q8N9I5	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	FADS6	Q8N9I5	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
Intra	FADS6	Q8N9I5	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
Intra	FADS6	Q8N9I5	PNKP	Homo sapiens	Q96T60	Validated Y2H	32296183
Intra	FADS6	Q8N9I5	KRTAP1-5	Homo sapiens	Q9BYS1	Y2H Array	32296183
Intra	FADS6	Q8N9I5	KRTAP1-5	Homo sapiens	Q9BYS1	Y2H Prey Pooling	32296183
Intra	FADS6	Q8N9I5	KRTAP1-5	Homo sapiens	Q9BYS1	Validated Y2H	32296183
Intra	FADS6	Q8N9I5	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	FADS6	Q8N9I5	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	FADS6	Q8N9I5	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	FADS6	Q8N9I5	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	FADS6	Q8N9I5	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Prey Pooling	32296183
Intra	FADS6	Q8N9I5	KRTAP3-3	Homo sapiens	Q9BYR6	Validated Y2H	32296183
Intra	FADS6	Q8N9I5	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Array	32296183
Intra	FADS6	Q8N9I5	DIABLO	Homo sapiens	Q9NR28	Validated Y2H	32296183
Intra	FADS6	Q8N9I5	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	FADS6	Q8N9I5	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	FADS6	Q8N9I5	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	FADS6	Q8N9I5	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	FADS6	Q8N9I5	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
Intra	FADS6	Q8N9I5	PBX3	Homo sapiens	Q96AL5	Validated Y2H	32296183
Intra	FADS6	Q8N9I5	INPP5K	Homo sapiens	Q9BT40	Validated Y2H	32296183
Intra	FADS6	Q8N9I5	MTERF3	Homo sapiens	Q96E29	Validated Y2H	32296183
Intra	FADS6	Q8N9I5	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	FADS6	Q8N9I5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	FADS6	Q8N9I5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	FADS6	Q8N9I5	TNS2	Homo sapiens	Q63HR2	Y2H Prey Pooling	32296183
Intra	FADS6	Q8N9I5	TNS2	Homo sapiens	Q63HR2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Fetal Akinesia Deformation Sequence 4	FADS4 Fetal Akinesia Deformation Sequence Syndrome 4 Akinesia, Fetal, Deformation Sequence, Type 4
Fetal Akinesia Deformation Sequence 1	Fetal Akinesia Deformation Sequence Fads Fetal Akinesia Sequence FADS1 Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia Pena-Shokeir Syndrome Type 1 Fetal Akinesia Deformation Sequence Syndrome Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia Pena-Shokeir Syndrome, Type I Foetal Akinesia Deformation Sequence Syndrome Foetal Akinesia Sequence Fetal Akinesia Deformation Sequence Syndrome 1 Pena-Shokeir Syndrome, Type 1 Pena Shokeir Syndrome, Type 1 Akinesia, Fetal, Deformation Sequence Akinesia, Fetal, Deformation Sequence, Type 1 Pena-Shokeir Syndrome Type I

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04666	FADS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04669	FADS6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FADS6	VGNC	VGNC:28704
Rattus norvegicus	FADS6	RGD	RGD:1311950
Canis familiaris	FADS6	VGNC	VGNC:40566
Felis catus	FADS6	VGNC	VGNC:62040
Mus musculus	FADS6	MGD	MGI:3039592
Others	FADS6	NCBI