HIPK1 - homeodomain interacting protein kinase 1 Gene

Also Known as Myak; Nbak2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 204851

About HIPK1

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:113,929,324-113,977,869 (from NCBI)

This gene has 11 transcripts (splice variants), 450 orthologues and 12 paralogues. Ubiquitous expression in bone marrow (RPKM 35.1), testis (RPKM 21.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]

HIPK1 Products (7)

mRNA Protein Name
NM_001369806.1 NP_001356735.1 homeodomain-interacting protein kinase 1 isoform 1
NM_001369807.1 NP_001356736.1 homeodomain-interacting protein kinase 1 isoform 5
NM_001410847.1 NP_001397776.1 homeodomain-interacting protein kinase 1 isoform 6
NM_152696.4 NP_689909.2 homeodomain-interacting protein kinase 1 isoform 2
NM_181358.3 NP_852003.1 homeodomain-interacting protein kinase 1 isoform 4
NM_198268.3 NP_938009.1 homeodomain-interacting protein kinase 1 isoform 1
NM_198269.3 NP_938010.1 homeodomain-interacting protein kinase 1 isoform 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12702766 GOA
Biological Process GO Annotation Evidence References Source
involved in endothelial cell apoptotic process IDA
IDA: Inferred from direct assay
15701637 GOA
involved in extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
15701637 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
24559171 GOA
involved in regulation of tumor necrosis factor-mediated signaling pathway IDA
IDA: Inferred from direct assay
15701637 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15701637 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15701637 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HIPK1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (190 - 518)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1210 a.a.
Protein Preferred Names Protein Names

homeodomain-interacting protein kinase 1

  • homeodomain interacting protein kinase 1-like protein

HIPK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HIPK1 Q86Z02 FHL3 Homo sapiens Q13643
Y2H Array
25416956
Intra
HIPK1 Q86Z02 FHL3 Homo sapiens Q13643
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-U00439A Protein kinase inhibitor 1 hydrochloride Inhibitor 98.0% Unkown
HY-125290 MU1210 Inhibitor 99.50% Unkown
HY-177416 MU1787 Inhibitor 99.84% Unkown
HY-RS06181 HIPK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17765 Hipk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24232 Hipk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HIPK1 RGD RGD:1304941
Mus musculus HIPK1 MGD MGI:1314873
Felis catus HIPK1 VGNC VGNC:62819
Canis familiaris HIPK1 VGNC VGNC:41693
Macaca mulatta HIPK1 VGNC VGNC:73420
Bos taurus HIPK1 VGNC VGNC:29859
Others HIPK1 NCBI