2. Gene
  3. HIPK1 - homeodomain interacting protein kinase 1 Gene

HIPK1 - homeodomain interacting protein kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as Myak; Nbak2

Gene ID: 204851 | Gene type: protein coding

About HIPK1

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:113,929,324-113,977,869 (from NCBI)

This gene has 11 transcripts (splice variants), 450 orthologues and 12 paralogues. Ubiquitous expression in bone marrow (RPKM 35.1), testis (RPKM 21.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]

HIPK1 Products(7)

mRNA Protein Name
NM_001369806.1 NP_001356735.1 homeodomain-interacting protein kinase 1 isoform 1
NM_001369807.1 NP_001356736.1 homeodomain-interacting protein kinase 1 isoform 5
NM_001410847.1 NP_001397776.1 homeodomain-interacting protein kinase 1 isoform 6
NM_152696.4 NP_689909.2 homeodomain-interacting protein kinase 1 isoform 2
NM_181358.3 NP_852003.1 homeodomain-interacting protein kinase 1 isoform 4
NM_198268.3 NP_938009.1 homeodomain-interacting protein kinase 1 isoform 1
NM_198269.3 NP_938010.1 homeodomain-interacting protein kinase 1 isoform 3 precursor

HIPK1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (190 - 518)

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  • 1210 a.a.
Protein Preferred Names Protein Names

homeodomain-interacting protein kinase 1

homeodomain interacting protein kinase 1-like protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-U00439A Protein kinase inhibitor 1 hydrochloride Inhibitor ≥98.0% Unkown
HY-RS06181 HIPK1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HIPK1 RGD RGD:1304941
Mus musculus HIPK1 MGD MGI:1314873
Felis catus HIPK1 VGNC VGNC:62819
Canis familiaris HIPK1 VGNC VGNC:41693
Macaca mulatta HIPK1 VGNC VGNC:73420
Bos taurus HIPK1 VGNC VGNC:29859
Others HIPK1 NCBI